Recombinant Human ATP2C1 Protein (Met1-Pro70), N-GST tagged

• Cat.No.: ATP2C1-0816H
• Product Overview: Recombinant Human ATP2C1 (Met1-Pro70) fused with the N-GST tag was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 34.72 kDa
• Protein length: Met1-Pro70
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02% NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 [ Homo sapiens (human) ]
• Official Symbol: ATP2C1
• Synonyms: ATP2C1; ATPase, Ca++ transporting, type 2C, member 1; BCPM, benign chronic pemphigus (Hailey Hailey disease); calcium-transporting ATPase type 2C member 1; ATP2C1A; KIAA1347; PMR1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1; HUSSY-28; ATPase 2C1; ATPase, Ca (2+)-sequestering; ATP-dependent Ca (2+) pump PMR1; HHD; BCPM; hSPCA1
• Gene ID: 27032
• mRNA Refseq: NM_001001485
• Protein Refseq: NP_001001485
• MIM: 604384
• UniProt ID: P98194

Reviews

10/17/2022

ATP2C1n's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

06/11/2022

Since the purity of the protein was indeed excellent, there were no visible impurities or contaminants.

11/22/2021

ATP2C1 is ideal for Western-blot analysis, with strong bands and clear specificity.

Q&As

What factors regulate the expression of ATP2C1?

The expression of ATP2C1 may be regulated by a variety of factors, including intracellular calcium levels, cell signaling pathways, transcription factors, and so on.

What is Hailey-Hailey disease?

Hailey-Hailey disease is a rare genetic skin disease characterized by skin inflammation and lesions.

What is the role of ATP2Cin skin cells?

It is a calcium transporter in skin cells and is responsible for the regulation of intracellular and extracellular calcium balance.

How do mutations in ATP2Ccause Hailey-Hailey disease?

The mutation of ATP2C1 may lead to the dysfunction of ATP2C1 protein and affect the calcium homeostasis in skin cells, which may lead to Hailey-Hailey disease.

How is ATP2Ctranscription and translation regulated?

The transcription and translation of ATP2C1 may be affected by various regulatory mechanisms such as chromatin alterations, activation of signaling pathways, and binding of transcription factors

What are the interactions of ATP2Cwith other proteins?

ATP2C1 may interact with some proteins related to intracellular calcium signaling pathway to further regulate calcium transport and intracellular balance.