Recombinant Human ATP2C1 cell lysate

• Cat.No.: ATP2C1-148HCL

Specification

• Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 [ Homo sapiens ]
• Official Symbol: ATP2C1
• Synonyms: ATP2C1; ATPase, Ca++ transporting, type 2C, member 1; BCPM, benign chronic pemphigus (Hailey Hailey disease); calcium-transporting ATPase type 2C member 1; ATP2C1A; KIAA1347; PMR1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1; HUSSY-28; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATP-dependent Ca(2+) pump PMR1; HHD; BCPM; hSPCA1
• Gene ID: 27032
• mRNA Refseq: NM_001001485
• Protein Refseq: NP_001001485
• MIM: 604384
• UniProt ID: P98194
• Chromosome Location: 3q21.3
• Pathway: Ion channel transport, organism-specific biosystem; Ion transport by P-type ATPases, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; calcium transport I, organism-specific biosystem
• Function: ATP binding; ATP binding; calcium ion binding; calcium-transporting ATPase activity; NOT calcium-transporting ATPase activity; calcium-transporting ATPase activity; calcium-transporting ATPase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; manganese ion binding; manganese-transporting ATPase activity; metal ion binding; nucleotide binding; signal transducer activity

Reviews

10/17/2022

ATP2C1n's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

06/11/2022

Since the purity of the protein was indeed excellent, there were no visible impurities or contaminants.

11/22/2021

ATP2C1 is ideal for Western-blot analysis, with strong bands and clear specificity.

Q&As

What factors regulate the expression of ATP2C1?

The expression of ATP2C1 may be regulated by a variety of factors, including intracellular calcium levels, cell signaling pathways, transcription factors, and so on.

What is Hailey-Hailey disease?

Hailey-Hailey disease is a rare genetic skin disease characterized by skin inflammation and lesions.

What is the role of ATP2Cin skin cells?

It is a calcium transporter in skin cells and is responsible for the regulation of intracellular and extracellular calcium balance.

How do mutations in ATP2Ccause Hailey-Hailey disease?

The mutation of ATP2C1 may lead to the dysfunction of ATP2C1 protein and affect the calcium homeostasis in skin cells, which may lead to Hailey-Hailey disease.

How is ATP2Ctranscription and translation regulated?

The transcription and translation of ATP2C1 may be affected by various regulatory mechanisms such as chromatin alterations, activation of signaling pathways, and binding of transcription factors

What are the interactions of ATP2Cwith other proteins?

ATP2C1 may interact with some proteins related to intracellular calcium signaling pathway to further regulate calcium transport and intracellular balance.