BIRC2

  • Official Full Name

    baculoviral IAP repeat containing 2

  • Overview

    The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms

    BIRC2; baculoviral IAP repeat containing 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • AVI
  • Flag
  • GST|StrepII
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|GST
  • His|S
  • His|StrepII
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BIRC2-3104H Active Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged E.coli AVI
Human BIRC2-01H Active Recombinant Human BIRC2 protein, His-tagged E.coli His
Human BIRC2-68H Recombinant Human BIRC2 protein, His/StrepII-tagged E.coli His/StrepII 258-363
Human BIRC2-1168H Recombinant Human BIRC2 protein, His & S-tagged E.coli His/S Asn148~Ser298
Human BIRC2-2633H Recombinant Human Baculoviral IAP Repeat-containing 2 E.coli N/A
Human BIRC2-67H Recombinant Human BIRC2 protein, GST/StrepII-tagged E.coli GST/StrepII 258-363
Human BIRC2-5894H Recombinant Human BIRC2 protein, His/GST-tagged E.coli His/GST
Human BIRC2-1169H Recombinant Human BIRC2 protein, His & GST-tagged E.coli His/GST Phe344~Gln593
Human BIRC2-27192TH Recombinant Human BIRC2 Wheat Germ N/A 618 amino acids
Human BIRC2-6874H Recombinant Human BIRC2, AVI tagged E.coli AVI
Human BIRC2-170HCL Recombinant Human BIRC2 cell lysate N/A
Human BIRC2-2587H Recombinant Human BIRC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BIRC2-954HFL Recombinant Full Length Human BIRC2 Protein, C-Flag-tagged Mammalian cells Flag
Human BIRC2-1483H Recombinant Human BIRC2 Protein (Phe344-Gln593), N-GST tagged E.coli N-GST Phe344-Gln593
Human BIRC2-448H Recombinant Human BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BIRC2-35HF Recombinant Full Length Human BIRC2 Protein In Vitro Cell Free System 618 amino acids
Human BIRC2-0713H Recombinant Human BIRC2 Protein (M1-S618), Tag Free Insect Cell No tag M1-S618
Human BIRC2-0714H Recombinant Human BIRC2 Protein (M1-S618), His/Strep tagged Insect Cell His/Strep M1-S618
Human BIRC2-448H-B Recombinant Human BIRC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse BIRC2-2408M Recombinant Mouse BIRC2 Protein Mammalian Cell His
Mouse Birc2-625M Recombinant Mouse Birc2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BIRC2-1035M-B Recombinant Mouse BIRC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse BIRC2-1035M Recombinant Mouse BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BIRC2-540R Recombinant Rhesus monkey BIRC2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BIRC2-368R Recombinant Rhesus Macaque BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BIRC2-368R-B Recombinant Rhesus Macaque BIRC2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BIRC2-9745Z Recombinant Zebrafish BIRC2 Mammalian Cell His
Chicken BIRC2-1748C Recombinant Chicken BIRC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayERC1;IL-8;TICAM2;PLCG2;CCL13;NFKB2;MAP3K7IP3;TRAF3;Ccl21c
Ubiquitin mediated proteolysisRHOBTB2;TRIP12;ANAPC11;UBE2N;HUWE1;PIAS4B;SKP1;BTRC;CDC26
ApoptosisPRKACB;CAPN2;DSG1;RELA;PIK3R3;E2F1;HIST1H1D;IRAK2;TP53
Hippo signaling pathwayYAP1;CTNNA3;FZD7;SAV1;STK3;WNT8A;ITGB2L;FZD2;WNT16
Focal adhesionHRASB;PDGFA;PAK6B;COL27A1;VEGFB;COL2A1;RAF1A;FLT4;THBS3
NOD-like receptor signaling pathwayCCL5;NAIP7;NFKBIAB;NLRP3;PYDC1;NFKBIAA;MAPK8;MAPK1;HSP90AA1.2
TNF signaling pathwayTNFRSF1B;MAPK13;ITCH;MAP3K14;MAPK8;CREB3L2;PIK3R1;CREB3L1;MAPK12
ToxoplasmosisIFNGR1;TYK2;BCL2;MAPK1;RELA;BCL2L1;AKT1;Toxoplasma Gondii Major Surface Antigen P30;LAMB2
Pathways in cancerAPPL1;RBX1;PDGFA;FZD8;CASP8;MET;IL6;FGF16;LAMA2
Small cell lung cancerRARB;BIRC7;ITGA2;TRAF4;LAMC2;XIAP;FN1;CKS2;LAMA1

BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activity involved in apoptotic processSERPINB9;C1QL4L;PRDX3;IGF1RA;BIRC2;SERPINB1A;BIRC5;VIL1;DPEP1
ligase activityRNF180;RANBP2;RNF6;RNF149;RNF146;TTLL2;TRIM22;MIB2;PCXB
protein N-terminus bindingSMARCE1;DAXX;ALOX5AP;STX1A;NIPBL;NCOA1;SNCA;TSC1;FEZ1
protein bindingTNFSF10;SALL1;CDKN1B;MORN3;NAA50;CD244;CKS1B;RFC5;VPS45
transcription coactivator activityKAT2A;PML;GATA3;MYCBP;KLF7;ESR2;NPAT;NR5A1;TADA3
ubiquitin-protein transferase activityMKRN1;MARCH4;TRIM69;FBXO3;UBE2Q2;ZNF738;RNF125;BTR22;ARIH1L
zinc ion bindingOAS1A;AGTPBP1;PHF19;VPS29;TRIM33;ADAM20;KAT7A;LIMS3L;MICAL1

BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.

TRAF2; CASP9; DIABLO

Research Area

Related articles

Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).
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