BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| NF-kappa B signaling pathway |
TRIM25; UBE2I; BIRC2; TICAM2; PLCG2; MYD88; BIRC3; CCL4L1; IRAK1; TRAF2 |
| Ubiquitin mediated proteolysis |
TRIM37; CUL4A; BTRC; UBE1Y1; SKP2; UBE2L3B; ITCH; CBLB; BIRC3; UBE4B |
| Apoptosis |
RELA; BAXA; CAPN1A; BIRC7; TNFRSF10B; IRAK1; CAPN2B; PIK3R1; PIK3CA; IL3 |
| Hippo signaling pathway |
PPP1CC; WNT16; SERPINE1; PPP2R2C; BMP5; SAV1; ID2; CCND1; MOBKL1A; BMPR1A |
| Focal adhesion |
AKT2; ITGB1B.2; VEGFB; CAV3; ITGA4; MAPK8B; VCLA; PAK4; LAMA2; MYL12A |
| NOD-like receptor signaling pathway |
HSP90AA1.1; Ccl12; PYDC1; NFKBIB; PSTPIP1A; TAB2; NAIP6; MAPK14A; NFKBIA; ERBB2IP |
| TNF signaling pathway |
TNF; Ccl12; IL6; PTGS2; IL15; MAGI2; MAPK9; CX3CL1; TNFRSF1B; BIRC2 |
| Toxoplasmosis |
PIK3CB; TAB2; SOCS1; H2-AB1; Toxoplasma Gondii Dense Granule Protein 7; TGFB1; MAPK10; IRGM; XIAP; HLA-DOB |
| Pathways in cancer |
TPM3; Adcy4; CCDC6; FGF1; GLI2; BAD; CXCR4; SFPI1; WNT7B; PTGER3 |
| Small cell lung cancer |
AKT1; BIRC8; IKBKG; IKBKB; APAF1; LAMA2; BIRC7; LAMB3; LAMA3; ITGAV |
BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.
| Function |
Related Protein |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
ARRB1; BIRC3; TNFAIP8; RPS6KA1; RPS6KA3; GAS6; DPEP1; C1QL4L; SERPINB9; BIRC5 |
| ligase activity |
RAG1; TMEM129; RNF31; TRIM13; GLULC; RBX1; RNF212; MARCH4; TRIM23; SH3RF2 |
| protein N-terminus binding |
ERCC3; RPS21; DCTN4; HDAC1; PEX5; TSC1; HESX1; STX5A; ALG2; SLC6A3 |
| protein binding |
EXOSC3; CST1; CTSD; HSBP1; BCL11B; SSU72; C3orf15; SNRPD1; LILRB4; FAM20A |
| transcription coactivator activity |
PML; PRRX1; MED7; TADA3; NRIP1; JMY; NR1H4; MED26; TAF6L; ECD |
| ubiquitin-protein transferase activity |
TRIM69; BIRC2; LNX1; RLIM; RNF125; MARCH6; DTX3L; MARCH5L; HERC2; TRAF5 |
| zinc ion binding |
MMP14; SUV39H1A; ERAP1; TNP2; TTC3; TCEA3; MT1E; PEG10; TRIM43B; LTA4H |
BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.
TRAF2; CASP9; DIABLO
Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).
