BIRC2
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Official Full Name
baculoviral IAP repeat containing 2 -
Overview
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
BIRC2;baculoviral IAP repeat containing 2;API1;MIHB;HIAP2;RNF48;cIAP1;Hiap-2;c-IAP1;baculoviral IAP repeat-containing protein 2;IAP-2;IAP homolog B;apoptosis inhibitor 1;RING finger protein 48;inhibitor of apoptosis protein 2;baculoviral IAP repeat-containing 2;NFR2-TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- In Vitro Cell Free System
- Avi
- His
- S
- GST
- Non
- Fc
- DDK
- Myc
- Flag
Involved Pathway
BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway,Ubiquitin mediated proteolysis,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TRAF3,TNFRSF1A,TNFRSF11A,VCAM1,BCL2A1,CCL21B,IL1B,UBE2I,ATM,PRKCB |
| NOD-like receptor signaling pathway | TRIP6,CXCL1,MAPK12B,CXCL2,NLRP3,RIPK2,CASP1,HSP90AA1.1,CARD18,TRAF6 |
| Apoptosis | E2F1,PIK3R3B,PPP3CCB,IRF4,CASP9,JUN,PRKAR2AB,IRAK4,IL3RA,HIST1H1B |
| Hippo signaling pathway | WNT8A,PARD6A,AFP,TGFB3,APC2,WNT3,AMH,WNT4,FZD5,SMAD3 |
| Focal adhesion | ROCK1,MAPK10,EGFRA,AKT2L,ARHGAP5,MYL5,AKT1,GSK3AA,RAPGEF1B,SRMS |
| TNF signaling pathway | AKT1,RELA,CASP10,PIK3CA,TRAF1,PIK3CB,MAP3K7,PIK3CD,IL15,CASP8 |
| Toxoplasmosis | MAPK13,TAB2,IRAK1,BIRC8,MAPK1,PIK3R3,PIK3CD,Casp3,BCL2L1,TGFB1 |
| Pathways in cancer | ARHGEF1,GNAI2,HHIP,MDM2,Shh,MAPK8,FZD3,NKX3,BAX,BIRC7 |
| Ubiquitin mediated proteolysis | SMURF2,CDC20,UBE2KA,UBE2L3A,FLJ11011L,RHOBTB2,UBE2J1,CDC16,SKP1,UBE1Y1 |
Protein Function
BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process,ligase activity,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KHK,PLXNB2,DCTN5,BMP2,EPOR,LINGO1B,NUP98,PFDN2,SNX9,PDE4C |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | NAIP1,C1QL4L,TNFSF14,DPEP1,IGF1RB,VIL1,SERPINB1A,AVP,RPS6KA1,IGF1RA |
| transcription coactivator activity | NFYC,HAND1,CITED4,EP300,NACA,TGFB1I1,TRIM24,TADA3,STIL,JUND |
| zinc ion binding | ZDHHC3,LHX2A,BTR16,ADAM7,SREK1IP1,RGN,DNAJC21,RNF39,LMO4,RNF212 |
| ligase activity | G2E3,E4F1,TRIM22,RNF38,RAG1,WWP2,RNF13,TRIM58,TRIM63,UBE2F |
| protein N-terminus binding | NCOA1,KCNIP1,PARP1,ID1,PEX19,MAU2,UNC13A,HDAC1,LACRT,PHB2 |
| ubiquitin-protein transferase activity | NSMCE1,MYCBP2,SHPRH,SIAH1A,AMFR,HACE1,TRIM56,TRIM5,UBE2E1,FBXL6 |
Interacting Protein
BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.
TRAF2;CASP9;DIABLO
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References
- Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
- Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).
