BIRC2 Protein


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Official Full Name baculoviral IAP repeat containing 2
Background The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Synonyms BIRC2; baculoviral IAP repeat containing 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • AVI
    • GST
    • StrepII
    • His
    • S
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC2-3104H Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged E.coli AVI
    Human BIRC2-01H Recombinant Human BIRC2 protein, His-tagged E.coli His
    Human BIRC2-5894H Recombinant Human BIRC2 protein, His/GST-tagged E.coli His/GST
    Human BIRC2-1168H Recombinant Human BIRC2 protein, His & S-tagged E.coli His/S
    Human BIRC2-1169H Recombinant Human BIRC2 protein, His & GST-tagged E.coli His/GST
    Human BIRC2-2633H Recombinant Human Baculoviral IAP Repeat-containing 2 E.coli N/A
    Human BIRC2-27192TH Recombinant Human BIRC2 Wheat Germ N/A
    Human BIRC2-67H Recombinant Human BIRC2 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC2-6874H Recombinant Human BIRC2, AVI tagged E.coli AVI
    Human BIRC2-68H Recombinant Human BIRC2 protein, His/StrepII-tagged E.coli His/StrepII
    Mouse BIRC2-2408M Recombinant Mouse BIRC2 Protein Mammalian Cell His
    Rhesus Macaque BIRC2-540R Recombinant Rhesus monkey BIRC2 Protein, His-tagged Mammalian Cell His
    Chicken BIRC2-1748C Recombinant Chicken BIRC2 Mammalian Cell His
    Zebrafish BIRC2-9745Z Recombinant Zebrafish BIRC2 Mammalian Cell His
    Human BIRC2-170HCL Recombinant Human BIRC2 cell lysate N/A
    Human BIRC2-35HF Recombinant Full Length Human BIRC2 Protein In Vitro Cell Free System
    Human BIRC2-2587H Recombinant Human BIRC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Birc2-625M Recombinant Mouse Birc2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway TRIM25; UBE2I; BIRC2; TICAM2; PLCG2; MYD88; BIRC3; CCL4L1; IRAK1; TRAF2
    Ubiquitin mediated proteolysis TRIM37; CUL4A; BTRC; UBE1Y1; SKP2; UBE2L3B; ITCH; CBLB; BIRC3; UBE4B
    Hippo signaling pathway PPP1CC; WNT16; SERPINE1; PPP2R2C; BMP5; SAV1; ID2; CCND1; MOBKL1A; BMPR1A
    Focal adhesion AKT2; ITGB1B.2; VEGFB; CAV3; ITGA4; MAPK8B; VCLA; PAK4; LAMA2; MYL12A
    NOD-like receptor signaling pathway HSP90AA1.1; Ccl12; PYDC1; NFKBIB; PSTPIP1A; TAB2; NAIP6; MAPK14A; NFKBIA; ERBB2IP
    TNF signaling pathway TNF; Ccl12; IL6; PTGS2; IL15; MAGI2; MAPK9; CX3CL1; TNFRSF1B; BIRC2
    Toxoplasmosis PIK3CB; TAB2; SOCS1; H2-AB1; Toxoplasma Gondii Dense Granule Protein 7; TGFB1; MAPK10; IRGM; XIAP; HLA-DOB
    Pathways in cancer TPM3; Adcy4; CCDC6; FGF1; GLI2; BAD; CXCR4; SFPI1; WNT7B; PTGER3
    Small cell lung cancer AKT1; BIRC8; IKBKG; IKBKB; APAF1; LAMA2; BIRC7; LAMB3; LAMA3; ITGAV

    BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process ARRB1; BIRC3; TNFAIP8; RPS6KA1; RPS6KA3; GAS6; DPEP1; C1QL4L; SERPINB9; BIRC5
    ligase activity RAG1; TMEM129; RNF31; TRIM13; GLULC; RBX1; RNF212; MARCH4; TRIM23; SH3RF2
    protein N-terminus binding ERCC3; RPS21; DCTN4; HDAC1; PEX5; TSC1; HESX1; STX5A; ALG2; SLC6A3
    protein binding EXOSC3; CST1; CTSD; HSBP1; BCL11B; SSU72; C3orf15; SNRPD1; LILRB4; FAM20A
    transcription coactivator activity PML; PRRX1; MED7; TADA3; NRIP1; JMY; NR1H4; MED26; TAF6L; ECD
    ubiquitin-protein transferase activity TRIM69; BIRC2; LNX1; RLIM; RNF125; MARCH6; DTX3L; MARCH5L; HERC2; TRAF5
    zinc ion binding MMP14; SUV39H1A; ERAP1; TNP2; TTC3; TCEA3; MT1E; PEG10; TRIM43B; LTA4H

    BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.


    Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
    Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).

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