BIRC2

  • Official Full Name

    baculoviral IAP repeat containing 2

  • Background

    The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms

    BIRC2; baculoviral IAP repeat containing 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • AVI
    • Flag
    • GST
    • GST|StrepII
    • His
    • His (Fc)
    • Avi
    • Strep
    • His|GST
    • His|S
    • His|StrepII
    • MYC
    • DDK
    • Myc|DDK
    • N/A
    • N
    • No tag
    Species Cat.# Product name Source (Host) Tag Price
    Human BIRC2-3104H Active Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged E.coli AVI
    Human BIRC2-01H Active Recombinant Human BIRC2 protein, His-tagged E.coli His
    Human BIRC2-68H Recombinant Human BIRC2 protein, His/StrepII-tagged E.coli His/StrepII
    Human BIRC2-1168H Recombinant Human BIRC2 protein, His & S-tagged E.coli His/S
    Human BIRC2-2633H Recombinant Human Baculoviral IAP Repeat-containing 2 E.coli N/A
    Human BIRC2-27192TH Recombinant Human BIRC2 Wheat Germ N/A
    Human BIRC2-5894H Recombinant Human BIRC2 protein, His/GST-tagged E.coli His/GST
    Human BIRC2-1169H Recombinant Human BIRC2 protein, His & GST-tagged E.coli His/GST
    Human BIRC2-6874H Recombinant Human BIRC2, AVI tagged E.coli AVI
    Human BIRC2-67H Recombinant Human BIRC2 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC2-170HCL Recombinant Human BIRC2 cell lysate N/A
    Human BIRC2-2587H Recombinant Human BIRC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BIRC2-954HFL Recombinant Full Length Human BIRC2 Protein, C-Flag-tagged Mammalian cells Flag
    Human BIRC2-0730H Recombinant Human BIRC2 Protein (Phe344-Gln593), GST tagged E.coli GST
    Human BIRC2-1483H Recombinant Human BIRC2 Protein (Phe344-Gln593), N-GST tagged E.coli N-GST
    Human BIRC2-448H Recombinant Human BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human BIRC2-35HF Recombinant Full Length Human BIRC2 Protein In Vitro Cell Free System
    Human BIRC2-0713H Recombinant Human BIRC2 Protein (M1-S618), Tag Free Insect Cell No tag
    Human BIRC2-0714H Recombinant Human BIRC2 Protein (M1-S618), His/Strep tagged Insect Cell His/Strep
    Human BIRC2-448H-B Recombinant Human BIRC2 Protein Pre-coupled Magnetic Beads HEK293
    Mouse BIRC2-2408M Recombinant Mouse BIRC2 Protein Mammalian Cell His
    Mouse Birc2-625M Recombinant Mouse Birc2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse BIRC2-1035M-B Recombinant Mouse BIRC2 Protein Pre-coupled Magnetic Beads HEK293
    Mouse BIRC2-1035M Recombinant Mouse BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque BIRC2-540R Recombinant Rhesus monkey BIRC2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque BIRC2-368R Recombinant Rhesus Macaque BIRC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque BIRC2-368R-B Recombinant Rhesus Macaque BIRC2 Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish BIRC2-9745Z Recombinant Zebrafish BIRC2 Mammalian Cell His
    Chicken BIRC2-1748C Recombinant Chicken BIRC2 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • BIRC2 Related Articles

    BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathwayTNF;TNFSF14;ATM;TNFRSF11A;PRKCQ;CXCL12;GM1987;BCL10;VCAM1
    Ubiquitin mediated proteolysisPML;UBE2NA;COP1;FBXW11A;TCEB2;CDC26;SOCS1A;ANAPC7;CUL3
    ApoptosisTNFRSF10C;DIABLO;YWHAQ;PRKACAA;IL3RA;BCL2L11;PLECA;CASP8;E2F1
    Hippo signaling pathwayTGFBR2;PPP2R2A;MPP5;LATS1;WWC1;GSK3B;TEAD1;CTNNA2;PPP1CA
    Focal adhesionPPP1CC;PAK3;SPP1;LAMC2;AKT3A;PARVG;AKT2;PDGFRB;ITGA6B
    NOD-like receptor signaling pathwayMAPK8A;PSTPIP1A;NAIP6;MAPK10;BIRC2;MAPK9;IL18;CASPA;CASP5
    TNF signaling pathwayATF4;MMP3;CASP7;CREB5;CXCL3;FAS;TNFRSF1A;ITCH;CREB3L3
    ToxoplasmosisNFKBIA;PIK3CD;GNAO1;ALOX5;BAD;MAPK13;XIAP;Toxoplasma Gondii Dense Granule Protein 7;LAMA4
    Pathways in cancerFGF20;PTGER1;IKBKG;CASP8;ITGA2;RB1;WNT2;EGLN2;PPARD
    Small cell lung cancerXIAP;BCL2;PIK3CA;IKBKG;IKBKB;ITGA2B;COL4A1;LAMA5;RXRA

    BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic processDPEP1;BIRC3;RPS6KA1;XIAP;BIRC7;TNFSF14;PRDX5;VIL1;C1QL4L
    ligase activityTRIM69;RLIM;HERC5;BIRC3;RNF6;BIRC7;MDM2;HECTD3;GLULC
    protein N-terminus bindingSNF8;VWF;PPP1CC;SUV39H1;HDAC1;SCT;HESX1;ACTN4;BIRC2
    protein bindingTMEM31;EPC1;ARHGAP4;C1QL1;ALOX5;SCYL1;SERBP1;TBCA;RACGAP1
    transcription coactivator activityGATA3;NR2C2;PIAS1;DDX5;CDK7;SP4;KDM5A;KAT2A;ENY2
    ubiquitin-protein transferase activityFBXL7;MUL1A;AMFR;UBE2D2A;FBXL14;TRIM71;TRIM27;MARCH8;RNF38
    zinc ion bindingMMP9;RNF187;MUL1B;LASP1;SUV39H2;MMP26;MARCH9;MMEL1;KNG1

    BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.

    TRAF2; CASP9; DIABLO

    Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
    Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).
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