BIRC2 Protein


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Official Full Name baculoviral IAP repeat containing 2
Background The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Synonyms BIRC2; baculoviral IAP repeat containing 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • AVI
    • GST
    • StrepII
    • His
    • S
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC2-5894H Recombinant Human BIRC2 protein, His/GST-tagged E.coli His/GST
    Human BIRC2-01H Recombinant Human BIRC2 protein, His-tagged E.coli His
    Human BIRC2-1168H Recombinant Human BIRC2 protein, His & S-tagged E.coli His/S
    Human BIRC2-1169H Recombinant Human BIRC2 protein, His & GST-tagged E.coli His/GST
    Human BIRC2-170HCL Recombinant Human BIRC2 cell lysate N/A
    Human BIRC2-2587H Recombinant Human BIRC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BIRC2-2633H Recombinant Human Baculoviral IAP Repeat-containing 2 E.coli N/A
    Human BIRC2-27192TH Recombinant Human BIRC2 Wheat Germ N/A
    Human BIRC2-3104H Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged E.coli AVI
    Human BIRC2-67H Recombinant Human BIRC2 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC2-6874H Recombinant Human BIRC2, AVI tagged E.coli AVI
    Human BIRC2-68H Recombinant Human BIRC2 protein, His/StrepII-tagged E.coli His/StrepII
    Mouse BIRC2-2408M Recombinant Mouse BIRC2 Protein Mammalian Cell His
    Mouse Birc2-625M Recombinant Mouse Birc2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque BIRC2-540R Recombinant Rhesus monkey BIRC2 Protein, His-tagged Mammalian Cell His
    Chicken BIRC2-1748C Recombinant Chicken BIRC2 Mammalian Cell His
    Zebrafish BIRC2-9745Z Recombinant Zebrafish BIRC2 Mammalian Cell His

    BIRC2 involved in several pathways and played different roles in them. We selected most pathways BIRC2 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway LYN; CD40LG; TLR4; CXCL12; IRAK4; MAP3K7; Ccl21a; TRAF2; BCL10; MAP3K7IP3
    Ubiquitin mediated proteolysis TCEB2; PIAS1; CUL3B; PML; UBA1; SOCS3B; ANAPC7; CUL5; RFWD2; UBE2D1A
    Hippo signaling pathway TGFB3; YWHAZ; PRKCZ; GDF5; FZD2; LLGL1; WNT3; AJUBA; STK3; WNT5B
    Focal adhesion CCND2; KDRL; PTENB; VAV3B; ITGA4; IGF1R; BCL2; VTN; COL27A1; CAPN2L
    NOD-like receptor signaling pathway TNFAIP3; NFKBIAA; NAIP6; HSP90AA1.2; TRAF6; TAB3; CARD9; PYDC1; RIPK2; TRIP6
    TNF signaling pathway PIK3CA; MAP2K7; PIK3R5; TAB2; MAP3K14; ICAM1; CXCL1; IL6; IL15; TNFRSF1B
    Toxoplasmosis STAT3; HSPA2; BIRC3; IL10RA; HLA-DOA; HLA-DRB3; TLR4; MAP3K7; LAMB2; PIK3R3
    Pathways in cancer ZBTB16; WNT8A; COL4A1; Adcy4; RB1; MMP1A; CXCL12; TPR; BIRC7; PTGS2
    Small cell lung cancer NFKBIA; LAMB2; NOS2; LAMB4; AKT1; BCL2; AKT2; CCNE1; LAMC2; SKP2

    BIRC2 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC2 itself. We selected most functions BIRC2 had, and list some proteins which have the same functions with BIRC2. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process AVP; TFAP2B; NAIP1; RPS6KA1; BIRC7; IGF1RA; PRDX5; GAS6; SNCA; DPEP1
    ligase activity UBE2D1B; RNF5; PIAS4; TRAF3; UHRF1; TTLL13; TRIM32; ZNRF1; MARCH11; SIAH2
    protein N-terminus binding NIPBL; SCFD1; PHB2; MAU2; STX5A; SUV39H1; KCNIP2; EIF5A; VPS25; ERCC2
    protein binding Apba1; HIST1H2BF; EIF6; TCF25; PFDN2; DAPK3; MESDC1; NUP62L; AP2B1; IQCB1
    transcription coactivator activity HCFC1; TFAP2A; MNT; TUBB3; UTF1; MED27; ZEB1; NCOA2; CDK7; JUNBB
    ubiquitin-protein transferase activity RNF135; RBBP6; PEX2; LMO7; UBE2G1; FBXL14B; TRIM36; DTX3L; RNF115; SIAH1
    zinc ion binding POLR2I; ADAMTSL3; ZNF622; POLE; USP16; MSRB2; TRIM3; ADAM10B; JUB; ZNRF1

    BIRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC2.


    Absalon-Medina, VA; Bedford-Guaus, SJ; et al. The effects of conjugated linoleic acid isomers cis-9,trans-11 and trans-10,cis-12 on in vitro bovine embryo production and cryopreservation. JOURNAL OF DAIRY SCIENCE 97:6164-6176(2014).
    Zhan, YB; Zhang, RM; et al. Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools. JOURNAL OF PERIODONTOLOGY 85:1059-1069(2014).

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