CA7
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Official Full Name
carbonic anhydrase VII
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Overview
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. -
Synonyms
CA7; carbonic anhydrase VII; carbonic anhydrase 7; CA 7; CA VII; CA-VII; CAH7_HUMAN; Car7; Carbonate dehydratase VII; Carbonic dehydratase; CAVII; OTTHUMP00000174821; OTTHUMP00000242940; carbonic dehydratase VII;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Strep
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
CA7 involved in several pathways and played different roles in them. We selected most pathways CA7 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | Car8;CAHZ;GLUL;Car9;CA8;GLUD1B;CA5;CA2;GLUD1A |
CA7 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA7 itself. We selected most functions CA7 had, and list some proteins which have the same functions with CA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | Car12;CAR15;CA14;CAR3;CAR7;CA13;CAR1;CAR6;CAR5A |
| zinc ion binding | LMO2;ZFML;KLF4;HNF4G;PEX12;TLL2;DNAJC24;LMX1B;IFIH1 |
CA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA7.
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Q&As (7)
Ask a questionCA7 facilitates the reversible hydration of carbon dioxide, but its specific kinetics might differ from other isoforms.
CA7 aids in CO2 transport and pH regulation, playing a crucial role in metabolic processes.
Dysregulation or mutations in CA7 might influence metabolic balance in tissues, potentially impacting conditions related to liver function or metabolism.
While some general carbonic anhydrase inhibitors might affect CA7, isoform-specific inhibitors would require further research.
CA7 is primarily expressed in the liver, among other tissues.
Potential modifications like phosphorylation or acetylation can be identified using techniques like mass spectrometry.
Specific mutations could alter CA7's enzyme kinetics or stability, requiring in vitro functional assays for verification.
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