Recombinant Human CA7

• Cat.No.: CA7-51H
• Product Overview: Recombinant Human Carbonic Anhydrase 7/CA7 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala264) of Human CA7.

Specification

• Description: Carbonic Anhydrase 7 (CA7) is a member of the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Furthermore, Alpha-carbonic anhydrase is associated with many biological processes, including calcification, respiration, bone resorption, acid-base balance and the formation of aqueous humor. CA7 is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine, but it is inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA) by saccharin and Foscarnet.
• Source: E. coli
• Species: Human
• Form: Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0
• AA Sequence: MTGHHGWGYGQDDGPSHWHKLYPIA QGDRQSPINIISSQAVYSPSLQPLE LSYEACMSLSITNNG HSVQVDFNDSDDRTVVTGGPLEGPY RLKQFHFHWGKKHDVGSEHTVDGKS FPSELHLVHWNAKKY STFGEAASAPDGLAVVGVFLETGDE HPSMNRLTDALYMVRFKGTKAQFSC FNPKCLLPASRHYWT YPGSLTTPPLSESVTWIVLREPICI SERQMGKFRSLLFTSEDDERIHMVN NFRPPQPLKGRVVKA SFRALEHHHHHH
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg).
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Storage: Store at Please minimize freeze-thaw cycles.
• Tag: Non
• Protein length: Met1-Ala264

Gene Information

• Gene Name: CA7 carbonic anhydrase VII [ Homo sapiens ]
• Official Symbol: CA7
• Synonyms: CA7; carbonic anhydrase VII; carbonic anhydrase 7; CA-VII; carbonic dehydratase VII; carbonate dehydratase VII; CAVII
• Gene ID: 766
• mRNA Refseq: NM_001014435
• Protein Refseq: NP_001014435
• MIM: 114770
• UniProt ID: P43166
• Chromosome Location: 16q22.1
• Function: carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding

Reviews

09/20/2022

Expertise in protein analysis, accelerates our research.

07/13/2021

Affordable pricing, excellent value for research budgets.

05/22/2021

Invaluable for our protein-related discoveries and innovations.

Q&As

What distinguishes the enzymatic function of CA7 from other carbonic anhydrase family members?

CA7 facilitates the reversible hydration of carbon dioxide, but its specific kinetics might differ from other isoforms.

How does CA7 contribute to cellular pH balance and metabolism?

CA7 aids in CO2 transport and pH regulation, playing a crucial role in metabolic processes.

Have any diseases or conditions been associated with aberrant CA7 expression or activity?

Dysregulation or mutations in CA7 might influence metabolic balance in tissues, potentially impacting conditions related to liver function or metabolism.

Are there compounds known to specifically inhibit CA7 activity?

While some general carbonic anhydrase inhibitors might affect CA7, isoform-specific inhibitors would require further research.

In which specific human tissues is CA7 expression most prevalent?

CA7 is primarily expressed in the liver, among other tissues.

What post-translational modifications are characteristic of CA7?

Potential modifications like phosphorylation or acetylation can be identified using techniques like mass spectrometry.

Are there any genetic mutations in the CA7 gene known to influence its enzymatic functionality?

Specific mutations could alter CA7's enzyme kinetics or stability, requiring in vitro functional assays for verification.