• Official Full Name

    chemokine (C-C motif) ligand 12

  • Background

    Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
  • Synonyms

    CCL12; chemokine (C-C motif) ligand 12; C-C motif chemokine 12; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12; MCP-1-related chemokine; small-inducible cytokine A12; monocyte chemotactic protein 5; monocyte chemoattractant protein 5; MCP-5;
    • Type:
    • Recombinant Proteins
    • Species :
    • Mouse
    • Source :
    • CHO
    • E. coli
    • E.coli
    • Yeast
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ccl12-310M Recombinant Mouse Ccl12 Protein, His-tagged Yeast His
    Mouse Ccl12-001M Recombinant Mouse Ccl12 Protein E.coli
    Mouse Ccl12-93M Recombinant Mouse Chemokine (C-C Motif) Ligand 12 E.coli N/A
    Mouse Ccl12-621M Recombinant Mouse Ccl12 protein E.coli N/A
    Mouse Ccl12-2028M Recombinant Mouse Ccl12 Protein E. coli
    Mouse Ccl12-224C Recombinant Mouse Ccl12 Protein (82 aa) CHO
    Mouse Ccl12-5247M Recombinant Mouse Ccl12 protein, His-tagged E.coli His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • Ccl12 Related Articles
    • Ccl12 Related Gene Family

    Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIL17B;CCL15;CCL5;IL11RA;INHBE;EDA2R;IL13;TNFRSF13C;KDRL
    Chemokine signaling pathwayLYN;CXCL14;PLCB3;WAS;PIK3CB;GNB2;CCL27;CCL3L3;CCL20
    NOD-like receptor signaling pathwayPSTPIP1A;PYDC1;Ccl12;HSP90AA1;MAPK8A;HSP90AA1.1;NLRP3;IL-8;LOC100033925
    TNF signaling pathwayATF4;MAP3K7;PIK3R2;VEGFC;MMP3;MAP3K14;TRADD;PIK3CA;PIK3CB
    Chagas disease (American trypanosomiasis)IL12B;NFKBIA;TLR2;AKT2;PPP2CA;MAPK13;NFKB1;MAPK3;PIK3R3
    Herpes simplex infectionTRAF5;IL6;NFKBIAA;PER1;GLTSCR2;CASP3B;TLR2-1;IFN-a;CDK1
    Rheumatoid arthritisCXCL12;IL-8;HLA-DRB3;IL11;H2-AB1;TNFSF13B;ATP6V0B;CCL3L1;CTLA4

    Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.

    Function Related Protein
    CCR2 chemokine receptor bindingCCL2;CCL7;Ccl12
    chemokine activityC5;CCL23;CXCL8B.3;CXCL3;CCL38A.4;CXCL18B;CCL3;CCL14;IL8L2
    cytokine activityIFNB;VEGFA;Ifna15;IL29;IL9;IFNA8;IL17A/F1;CMTM3;IFNB1

    Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.

    Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).
    Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).
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