Ccl12
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Official Full Name
chemokine (C-C motif) ligand 12 -
Overview
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation. -
Synonyms
CCL12;chemokine (C-C motif) ligand 12;C-C motif chemokine 12;Macrophage/monocyte Chemotactic Protein;OTTMUSP00000000792;Scya12;Small inducible cytokine A12;MCP-1-related chemokine;small-inducible cytokine A12;monocyte chemotactic protein 5;monocyte chemoattractant protein 5;MCP-5
Recombinant Proteins
- Mouse
- E.coli
- CHO
- Yeast
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Ccl12-001M |
Active Recombinant Mouse Ccl12 Protein
|
E.coli | Mouse |
|
||
| Ccl12-621M | Recombinant Mouse Ccl12 protein | E.coli | Mouse | Non | 82 |
|
| Ccl12-93M | Recombinant Mouse Chemokine (C-C Motif) Ligand 12 | E.coli | Mouse | Non |
|
|
| Ccl12-2028M | Active Recombinant Mouse Ccl12 Protein | E.coli | Mouse | Gly23-Gly104 |
|
|
| Ccl12-224C | Active Recombinant Mouse Ccl12 Protein (82 aa) | CHO | Mouse | 82 |
|
|
| Ccl12-310M | Recombinant Mouse Ccl12 protein(Gly23-Gly104), His-tagged | Yeast | Mouse | His | Gly23-Gly104 |
|
| Ccl12-5247M | Recombinant Mouse Ccl12 protein, His-tagged | E.coli | Mouse | His | 23-104aa |
|
Involved Pathway
Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chagas disease (American trypanosomiasis) | TLR6,CCL2,TGFBR1,IL10,CCL3L1,GNAQ,NFKBIA,PPP2R2A,TNF,GNAS |
| Cytokine-cytokine receptor interaction | CSF3R,IL26,TNFRSF9A,TNFRSF11B,CCR7,CCR5,CCL1,CXCL9,CCL20A.3,Il23a; Il12b |
| TNF signaling pathway | PGAM5,CXCL2,MAP3K5,AKT2,CXCL3,VEGFC,CCL5,MAP2K4,IL18R1,FADD |
| Chemokine signaling pathway | PF4,CCL21B,PPBP,CCL8,CCL22,GNAI2,PTK2,CCR10,PIK3R1,GNAI1 |
| Influenza A | IFNA16,Ifna15,MAPK11,MAPK10,NXF1,IFNA4,HLA-DRB1,HLA-DQB1,PABPN1,IFNB |
| Rheumatoid arthritis | HLA-DRB4,ITGAL,H2-AB1,TNFSF11,ACP5,HLA-DPB1,ATP6AP1,ATP6V0D2,CXCL12,IL17A |
| Malaria | KLRC4-KLRK1,IL12A,TNF,THBS1,THBS3,THBS4,LRP1,SDC1,COMP,GYPC |
| NOD-like receptor signaling pathway | ERBB2IP,NAIP6,MAPK10,CASP5,CARD9,CARD18,CASP8,LOC100033925,NLRP3,MAPK1 |
| Herpes simplex infection | NXF3,Ifna11,GLTSCR2,Fasl,CDK1,MHC2DEB,IFNA16,STAT2,TLR2,MAP3K7 |
Protein Function
Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding,chemokine activity,cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR2 chemokine receptor binding | CCL2,CCL7 |
| chemokine activity | Ccl21a,CCL8,CXCL10,CCL5,CXCL19,CCL38A.5,CCL44,CCL34B.9,IL-8,XCL2 |
| cytokine activity | TNFSF4,THPO,IFNA4,IL6,IFNA16,SECTM1,IFNA10,CSF2,IL36A,TXLNA |
Interacting Protein
Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.
Resources
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References
- Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).
- Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).
