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  • Official Full Name

    chemokine (C-C motif) ligand 12

  • Overview

    Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
  • Synonyms

    CCL12; chemokine (C-C motif) ligand 12; C-C motif chemokine 12; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12; MCP-1-related chemokine; small-inducible cytokine A12; monocyte chemotactic protein 5; monocyte chemoattractant protein 5; MCP-5;

  • Recombinant Proteins
  • Mouse
  • CHO
  • E. coli
  • E.coli
  • Yeast
  • C
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Ccl12-001M Active Recombinant Mouse Ccl12 Protein E.coli
Mouse Ccl12-93M Recombinant Mouse Chemokine (C-C Motif) Ligand 12 E.coli N/A
Mouse Ccl12-621M Recombinant Mouse Ccl12 protein E.coli N/A 82
Mouse Ccl12-310M Recombinant Mouse Ccl12 protein(Gly23-Gly104), His-tagged Yeast C-His Gly23-Gly104
Mouse Ccl12-224C Active Recombinant Mouse Ccl12 Protein (82 aa) CHO 82
Mouse Ccl12-2028M Active Recombinant Mouse Ccl12 Protein E. coli Gly23-Gly104
Mouse Ccl12-5247M Recombinant Mouse Ccl12 protein, His-tagged E.coli His 23-104aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ccl12 Related Articles
  • Ccl12 Related Gene Family

Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCNTF;CXCR3.2;RNF207B;INHBB;IFNAR1;CCL14;CXCL12A;CSF3;CCL21B
Chemokine signaling pathwayPLCB2;CCL6;IKBKG;PLCB1;RLN1;Cxcl15;CXCR1;GNG10;CCL14
NOD-like receptor signaling pathwayIL6;CARD9;NAIP7;MAPK13;TAB3;MAPK12A;MAPK12B;NLRP3;SGUT1
Chagas disease (American trypanosomiasis)MYD88;TGFBR2;IFNGR2;PLCB2;C1QA;MAPK10;IL-8;IRAK1;IL1B
Herpes simplex infectionGLTSCR2;HLA-DQA1;Hc;TAF9B;IFNPHI3;CRFB2;IL12BA;POU2F3;HLA-C
Rheumatoid arthritisMMP1A;HLA-DMB;TNF;HLA-DOA;TNFSF11;ATP6V1B1;ATP6V1C1;IL17A;Ctsl

Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.

Function Related Protein
CCR2 chemokine receptor bindingCCL2;Ccl12;CCL7
chemokine activityCCL23;CXCL18B;CCL19;CCL22;CXCL13;CCL35.2;CCL19A.2;CCL3L3;CX3CL1
cytokine activityIFNA21;CTF1;Il1f9;IL17A/F2;INHBC;TSLP;NRG1;IL15L;IL29

Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.

Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).
Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).
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