Ccl12

  • Official Full Name

    chemokine (C-C motif) ligand 12
  • Overview

    Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
  • Synonyms

    CCL12;chemokine (C-C motif) ligand 12;C-C motif chemokine 12;Macrophage/monocyte Chemotactic Protein;OTTMUSP00000000792;Scya12;Small inducible cytokine A12;MCP-1-related chemokine;small-inducible cytokine A12;monocyte chemotactic protein 5;monocyte chemoattractant protein 5;MCP-5

Recombinant Proteins

  • Mouse
  • E.coli
  • CHO
  • Yeast
  • Non
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
Ccl12-001M Active Recombinant Mouse Ccl12 Protein E.coli Mouse
Ccl12-621M Recombinant Mouse Ccl12 protein E.coli Mouse Non 82
Ccl12-93M Recombinant Mouse Chemokine (C-C Motif) Ligand 12 E.coli Mouse Non
Ccl12-2028M Active Recombinant Mouse Ccl12 Protein E.coli Mouse Gly23-Gly104
Ccl12-224C Active Recombinant Mouse Ccl12 Protein (82 aa) CHO Mouse 82
Ccl12-310M Recombinant Mouse Ccl12 protein(Gly23-Gly104), His-tagged Yeast Mouse His Gly23-Gly104
Ccl12-5247M Recombinant Mouse Ccl12 protein, His-tagged E.coli Mouse His 23-104aa

    Involved Pathway

    Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rheumatoid arthritis CTLA4,CXCL1,IL17A,HLA-DPA1,MMP1,MMP3,FOS,IL-8,CD28,ATP6V0E2
    Cytokine-cytokine receptor interaction ACVR1BA,IL11RA,IL21R,Ifna15,TNFSF15,GHR,GM1987,CXCR4B,GM13305,BMPR2B
    Influenza A PRSS2,RELA,FURIN,IL18,IL33,IFNA17,HLA-DOA,CYCS,TMPRSS2,SLC25A6
    NOD-like receptor signaling pathway HSP90AB1,IL-8,NLRP3,SGUT1,CASP1,IL18,NAIP1,MAPK12B,MAPK8A,MAPK1
    Herpes simplex infection IFNA8,H2-AA,IKBKG,IFNB,STAT1,HCFC2,SRSF4,SRSF2,TYK2,PER2
    Malaria HBB-B2,ITGB2,KLRC4-KLRK1,THBS1,THBS4,SELE,CD81,COMP,GYPC,THBS2
    TNF signaling pathway AKT2,CCL20,TRADD,DNM1L,MAP2K4,Casp3,MAP3K7IP3,PGAM5,CXCL2,PTGS2
    Chagas disease (American trypanosomiasis) C3,CALR,GNA14,TGFB3,SMAD2,CCL5,IL-8,NFKB1,CD247,IFNGR2
    Chemokine signaling pathway GNB2,STAT3,CCL18,CX3CL1,HRAS,MAP2K1,JAK2,Adcy4,CCR3,RAP1A

    Protein Function

    Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding,chemokine activity,cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.

    Function Related Protein
    chemokine activity Ccl21a,CCL19A.1,CCL20B,CCL22,CKLF,CXCL11.8,CXCL16,CCL19A.2,CCL5,CXCL12A
    cytokine activity INHBE,IL3,NAMPT,IFNA6,SCG2,RNF207B,IL1B,CD70,WNT5A,GM13287
    CCR2 chemokine receptor binding CCL7,CCL2

    Interacting Protein

    Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.

    Resources

    References

    • Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).
    • Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).

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