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Ccl12

Official Full Name

chemokine (C-C motif) ligand 12
Background

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Synonyms

CCL12; chemokine (C-C motif) ligand 12; C-C motif chemokine 12; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12; MCP-1-related chemokine; small-inducible cytokine A12; monocyte chemotactic protein 5; monocyte chemoattractant protein 5; MCP-5;

Type:
Recombinant Proteins

Species :
Mouse

Source :
CHO
E. coli
E.coli
Yeast

Tag :
His
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	Ccl12-310M	Recombinant Mouse Ccl12 Protein, His-tagged	Yeast	His	Inquiry
Mouse	Ccl12-001M	Recombinant Mouse Ccl12 Protein	E.coli		Inquiry
Mouse	Ccl12-93M	Recombinant Mouse Chemokine (C-C Motif) Ligand 12	E.coli	N/A	Inquiry
Mouse	Ccl12-621M	Recombinant Mouse Ccl12 protein	E.coli	N/A	Inquiry
Mouse	Ccl12-2028M	Recombinant Mouse Ccl12 Protein	E. coli		Inquiry
Mouse	Ccl12-224C	Recombinant Mouse Ccl12 Protein (82 aa)	CHO		Inquiry
Mouse	Ccl12-5247M	Recombinant Mouse Ccl12 protein, His-tagged	E.coli	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Ccl12 Related Articles
Ccl12 Related Gene Family

Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	IL17B;CCL15;CCL5;IL11RA;INHBE;EDA2R;IL13;TNFRSF13C;KDRL
Chemokine signaling pathway	LYN;CXCL14;PLCB3;WAS;PIK3CB;GNB2;CCL27;CCL3L3;CCL20
NOD-like receptor signaling pathway	PSTPIP1A;PYDC1;Ccl12;HSP90AA1;MAPK8A;HSP90AA1.1;NLRP3;IL-8;LOC100033925
TNF signaling pathway	ATF4;MAP3K7;PIK3R2;VEGFC;MMP3;MAP3K14;TRADD;PIK3CA;PIK3CB
Chagas disease (American trypanosomiasis)	IL12B;NFKBIA;TLR2;AKT2;PPP2CA;MAPK13;NFKB1;MAPK3;PIK3R3
Malaria	SELE;KLRB1;IL-8;HBB;SDC1;ITGB2L;TLR4;TGFB2;TLR9
Influenza A	GSK3B;MAPK8;STAT1;TNFRSF10A;KPNA2;TLR3;HLA-DRB1;HLA-DPA1;PLG
Herpes simplex infection	TRAF5;IL6;NFKBIAA;PER1;GLTSCR2;CASP3B;TLR2-1;IFN-a;CDK1
Rheumatoid arthritis	CXCL12;IL-8;HLA-DRB3;IL11;H2-AB1;TNFSF13B;ATP6V0B;CCL3L1;CTLA4

Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.

Function	Related Protein
CCR2 chemokine receptor binding	CCL2;CCL7;Ccl12
chemokine activity	C5;CCL23;CXCL8B.3;CXCL3;CCL38A.4;CXCL18B;CCL3;CCL14;IL8L2
cytokine activity	IFNB;VEGFA;Ifna15;IL29;IL9;IFNA8;IL17A/F1;CMTM3;IFNB1

Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.

Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).

Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).