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Ccl12

Official Full Name

chemokine (C-C motif) ligand 12
Overview

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Synonyms

CCL12; chemokine (C-C motif) ligand 12; C-C motif chemokine 12; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12; MCP-1-related chemokine; small-inducible cytokine A12; monocyte chemotactic protein 5; monocyte chemoattractant protein 5; MCP-5;

Type

Recombinant Proteins

Species

Mouse

Source

CHO
E.coli
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	Ccl12-001M	Active Recombinant Mouse Ccl12 Protein	E.coli			Inquiry
Mouse	Ccl12-93M	Recombinant Mouse Chemokine (C-C Motif) Ligand 12	E.coli	Non		Inquiry
Mouse	Ccl12-621M	Recombinant Mouse Ccl12 protein	E.coli	Non	82	Inquiry
Mouse	Ccl12-310M	Recombinant Mouse Ccl12 protein(Gly23-Gly104), His-tagged	Yeast	His	Gly23-Gly104	Inquiry
Mouse	Ccl12-224C	Active Recombinant Mouse Ccl12 Protein (82 aa)	CHO		82	Inquiry
Mouse	Ccl12-2028M	Active Recombinant Mouse Ccl12 Protein	E.coli		Gly23-Gly104	Inquiry
Mouse	Ccl12-5247M	Recombinant Mouse Ccl12 protein, His-tagged	E.coli	His	23-104aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	AMHR2;Il4ra;CCL4L1;IFNB;CCL19;FASLG;BMPR1A;PDGFRB;OSMR
Chemokine signaling pathway	GNAI3;PREX1;KRAS;PIK3CD;CXCL14;CX3CL1;LYN;PLCB2;CCR1
NOD-like receptor signaling pathway	NLRP3;MAPK8;PSTPIP1A;TRAF6;NAIP7;TNF;CARD18;PSTPIP1B;CARD8
TNF signaling pathway	CX3CL1;MAP2K1;ICAM1;ITCH;CXCL1;BAG4;IKBKB;TNF;NFKBIA
Chagas disease (American trypanosomiasis)	FOS;CXCL8;CD3D;SMAD2;MAPK12;MAPK8;CCL3;PIK3R2;CCL3L3
Malaria	TLR9;HBA-A2;HBB;GYPC;HBB-B2;KLRK1;CD81;TLR4;KLRC4-KLRK1
Influenza A	MAPK1;RELA;NLRP3;PRSS1;EP300;TMPRSS13;OAS1;BLB2;DDX39B
Herpes simplex infection	IFNAR2;HMGN1;PTPN11;PVRL1;TBK1;Casp3;RELA;THOC4;FOS
Rheumatoid arthritis	HLA-DRB1;MMP1;IL23;TNF;CXCL6;ATP6V0B;CD80;IL1B;ATP6V1H

Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.

Function	Related Protein
CCR2 chemokine receptor binding	CCL7;Ccl12;CCL2
chemokine activity	CCL34B.9;CCL18;CCL8;CCL20;CCL34B.4;CCL19B;PF4V1;PF4;Cxcl15
cytokine activity	GM13279;TNFB;TNFSF11;CD70;IL8L2;GDF15;VEGFA;GDF3;FASLG

Ccl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl12.

Gene Family

Research Area

Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).

Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).