CHD4
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Official Full Name
chromodomain helicase DNA binding protein 4
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Overview
Chromodomain-helicase-DNA-binding domain (CHD) proteins have been identified in a variety of organisms. This family of nine proteins is divided into three separate subfamilies: subfamily I (CHD1 and CHD2), subfamily II (CHD3 and CHD4), and subfamily III ( -
Synonyms
CHD4; chromodomain helicase DNA binding protein 4; chromodomain-helicase-DNA-binding protein 4; Mi 2b; Mi2 BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-BETA; DKFZp686E06161;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Baculovirus-Insect cells
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CHD4-27065TH | Recombinant Human CHD4 | Wheat Germ | N/A | 99 amino acids |
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| Human | CHD4-2434H | Recombinant Human CHD4 protein, His-tagged | Insect Cell | His |
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| Human | CHD4-2793H | Recombinant Human CHD4 protein, GST-tagged | Wheat Germ | GST |
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| Human | CHD4-346HCL | Recombinant Human CHD4 cell lysate | N/A |
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| Human | CHD4-5153H | Recombinant Human CHD4 protein, His&His-tagged | E.coli | His&His | 1-239aa |
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| Human | CHD4-772H | Recombinant Human CHD4 Protein, His-tagged | E.coli | N-His | Lys1681-Gln1912 |
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| Human | CHD4-0338H | Recombinant Human CHD4 Protein (Met1-Gln1912), C-His-tagged | Baculovirus-Insect cells | C-His | Met1-Gln1912 |
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| Human | CHD4-1180H | Recombinant Human CHD4 Protein (1-239 aa), His-tagged | E.coli | His | 1-239 aa |
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| Mouse | CHD4-3379M | Recombinant Mouse CHD4 Protein | Mammalian Cell | His |
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| Mouse | CHD4-1632M | Recombinant Mouse CHD4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | CHD4-1632M-B | Recombinant Mouse CHD4 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CHD4 involved in several pathways and played different roles in them. We selected most pathways CHD4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ING5A;KDM2AA;USP22;SAP30;KDM5A;ATXN7L3;KDM5D;JHDM1D;KDM4D |
| Chromatin organization | ING5;GATAD2A;BRD1;ATF7IP;USP22;C3orf75;JMJD6;KDM5A;MSL2B |
| Gene Expression | ZNF302;NRBF2;TNKS1BP1;SET;ZNF792;CHD4;YAP1;HNRNPUL1;ZNF254 |
| HDACs deacetylate histones | MTA2;MBD3;MBD3A;KDM1A;MBD3B;SAP18;ARID4A;SAP30;BRMS1 |
| RNA Polymerase I Promoter Clearance | MTA3;GATAD2A;TAF1B;EHMT2;CD3EAP;TAF1D;MTA1;UBTF;MBD3 |
| RNA Polymerase I Transcription | EFCAB11;GATAD2AB;TAF1D;MBD3;PTRFB;TAF1B;CD3EAP;GATAD2A;MBD3B |
| RNA Polymerase I Transcription Initiation | GATAD2B;MBD3A;MTA2;GATAD2A;MTA3;CHD4;MTA1;CHD4A;UBTF |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | GATAD2B;BRF1;ZNF143;GTF3A;SNAPC1A;CHD4A;CBX3A;POLR3GLA;SNAPC1B |
CHD4 has several biochemical functions, for example, ATP binding, ATP-dependent DNA helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHD4 itself. We selected most functions CHD4 had, and list some proteins which have the same functions with CHD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACVR1BA;AK7;CKMA;TOR1L3;NAT10;LIMK1A;ACVR2B;MTOR;TRPV1 |
| ATP-dependent DNA helicase activity | CHD2;DDX3X;GTF2H4;ERCC3;DHX9;CHD4;RECQL;RUVBL2;BLM |
| DNA binding | IKZF1;GSX1;FOXL1;MXI1;RCOR3;HES1;ZNF157;APLP2;CXXC1B |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | SMARCB1;SMARCC1;RBBP4;MTA2;HDAC1;MBD3;HDAC2;SMARCE1;CHD4 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | MBD3;RBBP4;ACTL6A;CHD4;HDAC1;SMARCA4;ACTB;HDAC2;SMARCC2 |
| RNA polymerase II repressing transcription factor binding | STAT3;SIN3A;CHD4;PROL1;MKKS;TTC8;RBBP8;BBS4;BBS5 |
| microtubule binding | MAPRE2;TRIM54;VAPB;TPPP;PAFAH1B1A;NDE1;KIF1B;MAPRE3B;PRC1 |
| contributes_to nucleosomal DNA binding | SMARCC1;RBBP4;SMARCE1;MTA2;HDAC1;SMARCA4;GATAD2B;MBD3;HDAC2 |
| protein binding | PAQR5;LNX2B;RGR;LRRK1;FAM46D;GJB6;PABPC1;MGRN1;CNEP1R1 |
| zinc ion binding | PCGF6;RBM4.2;NR1I3;ZNF8;LMO4;MMP13;GATA2A;UNK;MT3 |
CHD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHD4.
HDAC1; E7; HDAC2; MYC; MTA2; MBD3; RNF8; NR4A1; TAF9; USP36
Research Area
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Q&As (7)
Ask a questionCHD4 collaborates with the NuRD complex in chromatin remodeling.
CHD4 regulates gene transcription via chromatin accessibility.
CHD4 alters chromatin structure, aiding in DNA accessibility.
Genetic changes in CHD4 affect gene expression and cellular function.
Altered CHD4 activity is associated with cancer progression.
It remodels chromatin for efficient DNA repair.
Targeting CHD4 offers potential cancer treatment strategies by affecting cell growth.
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