• Official Full Name

    chromodomain helicase DNA binding protein 4

  • Overview

    Chromodomain-helicase-DNA-binding domain (CHD) proteins have been identified in a variety of organisms. This family of nine proteins is divided into three separate subfamilies: subfamily I (CHD1 and CHD2), subfamily II (CHD3 and CHD4), and subfamily III (
  • Synonyms

    CHD4; chromodomain helicase DNA binding protein 4; chromodomain-helicase-DNA-binding protein 4; Mi 2b; Mi2 BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-BETA; DKFZp686E06161;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHD4-27065TH Recombinant Human CHD4 Wheat Germ N/A 99 amino acids
Human CHD4-2434H Recombinant Human CHD4 protein, His-tagged Insect Cell His
Human CHD4-2793H Recombinant Human CHD4 protein, GST-tagged Wheat Germ GST
Human CHD4-346HCL Recombinant Human CHD4 cell lysate N/A
Human CHD4-5153H Recombinant Human CHD4 protein, His&His-tagged E.coli His&His 1-239aa
Human CHD4-772H Recombinant Human CHD4 Protein, His-tagged E.coli N-His Lys1681-Gln1912
Human CHD4-0338H Recombinant Human CHD4 Protein (Met1-Gln1912), C-His-tagged Baculovirus-Insect cells C-His Met1-Gln1912
Human CHD4-1180H Recombinant Human CHD4 Protein (1-239 aa), His-tagged E.coli His 1-239 aa
Mouse CHD4-3379M Recombinant Mouse CHD4 Protein Mammalian Cell His
Mouse CHD4-1632M Recombinant Mouse CHD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CHD4-1632M-B Recombinant Mouse CHD4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CHD4 involved in several pathways and played different roles in them. We selected most pathways CHD4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesING5A;KDM2AA;USP22;SAP30;KDM5A;ATXN7L3;KDM5D;JHDM1D;KDM4D
Chromatin organizationING5;GATAD2A;BRD1;ATF7IP;USP22;C3orf75;JMJD6;KDM5A;MSL2B
HDACs deacetylate histonesMTA2;MBD3;MBD3A;KDM1A;MBD3B;SAP18;ARID4A;SAP30;BRMS1
RNA Polymerase I Promoter ClearanceMTA3;GATAD2A;TAF1B;EHMT2;CD3EAP;TAF1D;MTA1;UBTF;MBD3
RNA Polymerase I Transcription InitiationGATAD2B;MBD3A;MTA2;GATAD2A;MTA3;CHD4;MTA1;CHD4A;UBTF
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionGATAD2B;BRF1;ZNF143;GTF3A;SNAPC1A;CHD4A;CBX3A;POLR3GLA;SNAPC1B

CHD4 has several biochemical functions, for example, ATP binding, ATP-dependent DNA helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHD4 itself. We selected most functions CHD4 had, and list some proteins which have the same functions with CHD4. You can find most of the proteins on our site.

Function Related Protein
ATP-dependent DNA helicase activityCHD2;DDX3X;GTF2H4;ERCC3;DHX9;CHD4;RECQL;RUVBL2;BLM
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA bindingSMARCB1;SMARCC1;RBBP4;MTA2;HDAC1;MBD3;HDAC2;SMARCE1;CHD4
contributes_to RNA polymerase II distal enhancer sequence-specific DNA bindingMBD3;RBBP4;ACTL6A;CHD4;HDAC1;SMARCA4;ACTB;HDAC2;SMARCC2
RNA polymerase II repressing transcription factor bindingSTAT3;SIN3A;CHD4;PROL1;MKKS;TTC8;RBBP8;BBS4;BBS5
contributes_to nucleosomal DNA bindingSMARCC1;RBBP4;SMARCE1;MTA2;HDAC1;SMARCA4;GATAD2B;MBD3;HDAC2
zinc ion bindingPCGF6;RBM4.2;NR1I3;ZNF8;LMO4;MMP13;GATA2A;UNK;MT3

CHD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHD4.


Research Area

  • Q&As
  • Reviews

Q&As (7)

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How does CHD4 interact with other components of the chromatin remodeling complex? 01/09/2022

CHD4 collaborates with the NuRD complex in chromatin remodeling.

What role does CHD4 play in gene regulation? 08/16/2021

CHD4 regulates gene transcription via chromatin accessibility.

What is the primary role of CHD4 in chromatin remodeling? 07/29/2020

CHD4 alters chromatin structure, aiding in DNA accessibility.

How do genetic variations in CHD4 affect gene expression? 05/11/2020

Genetic changes in CHD4 affect gene expression and cellular function.

What is the impact of altered CHD4 activity on cancer development? 09/12/2019

Altered CHD4 activity is associated with cancer progression.

How does CHD4 contribute to DNA damage repair? 05/05/2017

It remodels chromatin for efficient DNA repair.

What potential therapeutic applications arise from targeting CHD4 in cancer treatment? 03/29/2017

Targeting CHD4 offers potential cancer treatment strategies by affecting cell growth.

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