COX6B1 Protein


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Official Full Name cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
Background Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
Synonyms COX6B1; cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous); COX6B, cytochrome c oxidase subunit Vib , cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous); cytochrome c oxidase subunit 6B1; COXG; COX VIb-1; COX6B; COXVIb1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX6B1-11496H Recombinant Human COX6B1, GST-tagged E.coli GST
    Human COX6B1-1754H Recombinant Human COX6B1 Protein, GST-tagged Wheat Germ GST
    Human COX6B1-1802H Recombinant Human COX6B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human COX6B1-27556TH Recombinant Human COX6B1 Wheat Germ N/A
    Human COX6B1-7329HCL Recombinant Human COX6B1 293 Cell Lysate HEK293 N/A
    Mouse COX6B1-3819M Recombinant Mouse COX6B1 Protein Mammalian Cell His
    Mouse Cox6b1-464M Recombinant Mouse Cox6b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque COX6B1-992R Recombinant Rhesus monkey COX6B1 Protein, His-tagged Mammalian Cell His
    Zebrafish COX6B1-799Z Recombinant Zebrafish COX6B1 Mammalian Cell His

    COX6B1 involved in several pathways and played different roles in them. We selected most pathways COX6B1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease NDUFV1; NOS1; CALM2; ATP5F1; ATP5A1; APP; ATP5O; IL1B; NDUFB6; COX7A1
    Cardiac muscle contraction TPMA; CACNA2D2; COX7C; ATP1B3B; CACNA2D3; COX4I2; ATP1B1B; TPM3; SLC8A1; TNNC1B
    Electron Transport Chain NDUFC2-KCTD14; COX6C; SLC25A14; COX6A2; NDUFS7; SLC25A27; ATP5S; SURF1; ATPIF1; COX15
    Gene Expression HNRPL; MED31; UHRF1; MED16; ZNF669; PTBP1B; ZNF445; ZNF254; POLR3F; ADARB1A
    Generic Transcription Pathway ZNF596; ZNF560; ZNF334; ZNF486; NR1I3; NR2F1; ZNF227; ZNF155; NR0B1; LAMTOR1
    Huntingtons disease mt-Atp8; NDUFB8; DNAL1; POLR2J2; SLC25A5; NDUFA10; SDHB; NDUFA12; COX4I2; GPX1
    Metabolic pathways GCDHB; LSS; NDUFS4; PFKP; MINPP1A; CDO1; G6PD; ATP6V0A1A; ACSS2L; PPAT
    Metabolism AMD2; SLC23A2; GSTK1; FMODA; OAZ1A; MED16; VAPB; CDIPT; GLRX; GYG1A

    COX6B1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6B1 itself. We selected most functions COX6B1 had, and list some proteins which have the same functions with COX6B1. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX8C; COX7A1; COX7B; SURF1; COX5AA; COX5A; COX7A2; COX5B2; COX7C; COX6B2

    COX6B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6B1.

    env; 40038273; MT-CO2; VPS26A; Zbtb7a; Cdc6; YEATS4; XRCC5; Rab5c; HTT; RAB5C; POLR2G; TMEM132A; Ankfy1; Sidt2; YIPF5; TIMMDC1; VAPA

    Abdulhag, UN; Soiferman, D; et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. EUROPEAN JOURNAL OF HUMAN GENETICS 23:159-164(2015).
    Lim, J; Liu, ZB; et al. Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet. PLOS ONE 9:-(2014).

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