COX6B1

  • Official Full Name

    cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)

  • Overview

    Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
  • Synonyms

    COX6B1; cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous); COX6B, cytochrome c oxidase subunit Vib , cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous); cytochrome c oxidase subunit 6B1; COXG; COX VIb-1; COX6B; COXVIb1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COX6B1-27556TH Recombinant Human COX6B1 Wheat Germ N/A
Human COX6B1-11496H Recombinant Human COX6B1, GST-tagged E.coli GST
Human COX6B1-1754H Recombinant Human COX6B1 Protein, GST-tagged Wheat Germ GST
Human COX6B1-7329HCL Recombinant Human COX6B1 293 Cell Lysate HEK293 N/A
Human COX6B1-2011HF Recombinant Full Length Human COX6B1 Protein, GST-tagged In Vitro Cell Free System GST
Human COX6B1-94HF Recombinant Full Length Human COX6B1 Protein In Vitro Cell Free System
Human COX6B1-2012HFL Recombinant Full Length Human COX6B1 Protein, C-Flag-tagged Mammalian cells Flag
Human COX6B1-1802H Recombinant Human COX6B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COX6B1-649H Recombinant Human COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human COX6B1-649H-B Recombinant Human COX6B1 Protein Pre-coupled Magnetic Beads HEK293
Mouse COX6B1-3819M Recombinant Mouse COX6B1 Protein Mammalian Cell His
Mouse COX6B1-1917M-B Recombinant Mouse COX6B1 Protein Pre-coupled Magnetic Beads HEK293
Mouse COX6B1-1917M Recombinant Mouse COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cox6b1-464M Recombinant Mouse Cox6b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque COX6B1-992R Recombinant Rhesus monkey COX6B1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COX6B1-817R Recombinant Rhesus Macaque COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque COX6B1-817R-B Recombinant Rhesus Macaque COX6B1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish COX6B1-799Z Recombinant Zebrafish COX6B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COX6B1 Related Articles

COX6B1 involved in several pathways and played different roles in them. We selected most pathways COX6B1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseCasp3;ATP2A2;LRP1;IL1B;COX4I1;CYCS;SNCA;ATP5J;NDUFA5
Cardiac muscle contractionCOX7B2;COX7B;ATP1B3B;CACNB2A;TNNI3;COX7A3;CACNG8;CACNA1D;VMHCL
Electron Transport ChainATP5H;COX6B1;SLC25A14;SLC25A27;COX15;ATP5L;COX4I1;COX6C;ATPIF1
Gene ExpressionPCBP2;LSM11;POLR3C;HNRNPH2;ZNF443;ZNF573;ZNF773;TRMT1;METTL1
Generic Transcription PathwayZNF530;RNF111;TRIM33;ZNF786;ZNF839;ZNF480;NR0B2A;ZNF114;ZNF333
Huntingtons diseaseCasp3;TGM2;EP300;DNAH14;NDUFS5;NDUFC2-KCTD14;DNAIC2;TBP;NDUFV2
Metabolic pathwaysTGDS;PIGF;AGPAT5;GATM;NT5E;EHHADH;POLR2J3;ALOX12B;DPYDB
MetabolismFAAH2;ADH8B;ITPA;CYP2D6;ALDH9A1A.2;MED8;CYP17A1;CYP3A7-CYP3AP1;NOSTRIN

COX6B1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6B1 itself. We selected most functions COX6B1 had, and list some proteins which have the same functions with COX6B1. You can find most of the proteins on our site.

Function Related Protein
cytochrome-c oxidase activityCOX4I1;COA6;COX6B2;COX7B;COX7A2A;COX6C;COX6A1;COX5AA;CYB5A

COX6B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6B1.

env; 40038273; MT-CO2; VPS26A; Zbtb7a; Cdc6; YEATS4; XRCC5; Rab5c; HTT; RAB5C; POLR2G; TMEM132A; Ankfy1; Sidt2; YIPF5; TIMMDC1; VAPA

Abdulhag, UN; Soiferman, D; et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. EUROPEAN JOURNAL OF HUMAN GENETICS 23:159-164(2015).
Lim, J; Liu, ZB; et al. Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet. PLOS ONE 9:-(2014).
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