COX6B1 Protein


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Official Full Name cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
Background Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
Synonyms COX6B1; cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous); COX6B, cytochrome c oxidase subunit Vib , cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous); cytochrome c oxidase subunit 6B1; COXG; COX VIb-1; COX6B; COXVIb1;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX6B1-11496H Recombinant Human COX6B1, GST-tagged E.coli GST Inquiry
    Human COX6B1-1754H Recombinant Human COX6B1 Protein, GST-tagged Wheat Germ GST Inquiry
    Human COX6B1-27556TH Recombinant Human COX6B1 Wheat Germ N/A Inquiry
    Mouse COX6B1-3819M Recombinant Mouse COX6B1 Protein Mammalian Cell His Inquiry
    Rhesus Macaque COX6B1-992R Recombinant Rhesus monkey COX6B1 Protein, His-tagged Mammalian Cell His Inquiry
    Zebrafish COX6B1-799Z Recombinant Zebrafish COX6B1 Mammalian Cell His Inquiry
    Human COX6B1-7329HCL Recombinant Human COX6B1 293 Cell Lysate HEK293 N/A Inquiry
    Mouse COX6B1-1917M Recombinant Mouse COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human COX6B1-2011HF Recombinant Full Length Human COX6B1 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human COX6B1-2012HFL Recombinant Full Length Human COX6B1 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human COX6B1-649H Recombinant Human COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rhesus Macaque COX6B1-817R Recombinant Rhesus Macaque COX6B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human COX6B1-94HF Recombinant Full Length Human COX6B1 Protein In Vitro Cell Free System Inquiry
    Human COX6B1-1802H Recombinant Human COX6B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Cox6b1-464M Recombinant Mouse Cox6b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry

    COX6B1 involved in several pathways and played different roles in them. We selected most pathways COX6B1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease NDUFB9; NDUFA7; APAF1; NDUFC2-KCTD14; NDUFB8; BID; MME; ATP2A2; TNF; BACE2
    Cardiac muscle contraction TPM2; COX5AA; UQCR11; ATP1B3B; ACTC1B; COX7C; TPM4A; CACNB1; COX5B; CACNG4
    Electron Transport Chain COX6C; ATP5S; COX11; SCO1; SURF1; COX15; UCP2; NDUFS7; COX4I1; COX6A1
    Gene Expression ZNF839; ZNF192; GTF3AB; HBXIP; CSTF2; ZNF550; DNMT1; DCP2; ZNF311; ZNF697
    Generic Transcription Pathway ZNF74; HELZ2; NRBP1; ZNF498; ZNF317; SURF1; PRDM7; NR2F1A; ZNF157; Txn1
    Huntingtons disease ITPR1; NDUFV1; NDUFS6; COX7A2L; DNAIC2; DNAHC8; UQCR11; VDAC2; NDUFA7; ATP5B
    Metabolic pathways ST6GALNAC4; glpK; SEPHS2; GLULA; AANAT1; UQCRC1; PGK1; SMS; GLDC; CYP2C39

    COX6B1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6B1 itself. We selected most functions COX6B1 had, and list some proteins which have the same functions with COX6B1. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX7C; COA6; COX6A1; COX7A2L; COX6B2; COX7A1; COX7A3; COX15; COX7B; COX11

    COX6B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6B1.

    env; 40038273; MT-CO2; VPS26A; Zbtb7a; Cdc6; YEATS4; XRCC5; Rab5c; HTT; RAB5C; POLR2G; TMEM132A; Ankfy1; Sidt2; YIPF5; TIMMDC1; VAPA

    Abdulhag, UN; Soiferman, D; et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. EUROPEAN JOURNAL OF HUMAN GENETICS 23:159-164(2015).
    Lim, J; Liu, ZB; et al. Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet. PLOS ONE 9:-(2014).

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