CTTN

  • Official Full Name

    cortactin

  • Overview

    This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
  • Synonyms

    CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin; amplaxin; 1110020L01Rik; oncogene EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTTN-27H Recombinant Human CTTN, GST-tagged Wheat Germ GST
Human CTTN-28H Recombinant Human CTTN, MYC/DDK-tagged HEK293 Myc/DDK
Human CTTN-27962TH Recombinant Human CTTN, His-tagged E.coli His
Human CTTN-782H Recombinant Human CTTN Protein, DDK-tagged Sf9 Insect Cell DDK
Human CTTN-421HCL Recombinant Human CTTN cell lysate N/A
Human CTTN-9124HFL Recombinant Full Length Human CTTN, Flag-tagged Mamanlian cells Flag
Human CTTN-6371H Recombinant Human CTTN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTTN-2018HFL Recombinant Full Length Human CTTN protein, Flag-tagged Mamanlian cells Flag
Mouse Cttn-431M Recombinant Mouse Cttn Protein, His-tagged E.coli His Met1~Gln509
Rat CTTN-1671R Recombinant Rat CTTN Protein Mammalian Cell His
Rat CTTN-1330R Recombinant Rat CTTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cttn-432R Recombinant Rat Cttn Protein, His-tagged E.coli His Met1~Gln509
Rat CTTN-1330R-B Recombinant Rat CTTN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTTN-1090R Recombinant Rhesus monkey CTTN Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTTN-915R-B Recombinant Rhesus Macaque CTTN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTTN-915R Recombinant Rhesus Macaque CTTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CTTN-1230Z Recombinant Zebrafish CTTN Mammalian Cell His
Chicken CTTN-7017C Recombinant Chicken CTTN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CTTN involved in several pathways and played different roles in them. We selected most pathways CTTN participated on our site, such as Tight junction, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tight junctionPTENB;MYL9A;EPB41L3A;ACTN2;CLDNE;CLDN3;MAGI2;MYL12.2;MYH8
Bacterial invasion of epithelial cellsFN1;ARPC5;CLTA;PIK3CG;ITGB1;SEPT6;DNM3;SEPT1;PIK3CB
Pathogenic Escherichia coli infectionHCLS1;ARPC5L;TUBAL3;TUBA1B;CDH1;TUBB6;CD14;TUBA3D;YWHAZ
ShigellosisELMO3;BTRC;RELA;RHOG;ABL1;ATG5;ROCK2;NFKBIA;U2AF1L4
Proteoglycans in cancerFzd4;TRP53;PIK3CD;WNT5A;NRAS;WNT8B;PRKACB;DROSHA;MAPK3

CTTN has several biochemical functions, for example, profilin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTTN itself. We selected most functions CTTN had, and list some proteins which have the same functions with CTTN. You can find most of the proteins on our site.

Function Related Protein
profilin bindingPCLO;WIPF1;CTTN;HTT;DIAPH1;EVL;VASP;FMNL1;CYFIP1
protein bindingTSNAX;TSGA10;TRPV5;C5orf24;RABGAP1;ETL4;NUP62L;NFKBIA;ILVBL

CTTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTTN here. Most of them are supplied by our site. Hope this information will be useful for your research of CTTN.

ASAP1; DNM2; GRB2; Kcnma1; ARRB2

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any molecular pathways that interact with CTTN protein in cancer cells? 03/20/2022

Yes, CTTN protein interacts with various signaling pathways involved in cancer progression, including those regulating cell migration and invasion.

How is CTTN protein expression assessed in clinical settings? 01/12/2022

CTTN protein expression can be evaluated using immunohistochemistry on tumor tissue samples obtained from patients.

Are there any non-cancer clinical applications of CTTN protein? 08/01/2020

Yes, CTTN protein has been implicated in neurological disorders such as Alzheimer's disease, and its role in these conditions is also being investigated.

Is CTTN protein involved in other cellular functions besides cancer progression? 03/21/2019

Yes, CTTN protein is involved in various cellular processes such as cell adhesion, migration, and cytoskeletal dynamics.

How is CTTN protein expression regulated in cancer cells? 01/17/2016

CTTN protein expression can be regulated by various factors, including oncogenes, tumor suppressor genes, and signaling pathways involved in cancer development.

Customer Reviews (3)

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Reviews
01/19/2021

    Its high quality, coupled with the manufacturer's exceptional technical support, make it a reliable and effective choice for addressing my scientific inquiries.

    05/17/2017

      This has greatly facilitated my experimental workflow, ensuring a readily available and dependable protein source whenever I need it.

      12/15/2016

        I confidently recommend the CTTN protein to any researcher seeking a superior protein that not only fulfills their experimental needs but is also backed by unparalleled support from the manufacturer.

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