| Description : |
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57.5 kDa |
| AA Sequence : |
MWKASAGHAVSIAQDDAGADDWETD PDFVNDVSEKEQRWGAKTVQGSGHQ EHINIHKLRENVFQEHQTLKEKELE TGPKASHGYGGKFGVEQDRMDKSAV GHEYQSKLSKHCSQVDSVRGFGGKF GVQMDRVDQSAVGFEYQGKTEKHAS QKDYSSGFGGKYGVQADRVDKSAVG FDYQGKTEKHESQRDYSKGFGGKYG IDKDKVDKSAVGFEYQGKTEKHESQ KDYVKGFGGKFGVQTDRQDKCALGW DHQEKLQLHESQKDYSKGFGGKYGV QKDRMDKNASTFEDVTQVSSAYQKT VPVEAVTSKTSNIRANFENLAKEKE QEDRRKAEAERAQRMAKERQEQEEA RRKLEEQARAKTQTPPVSPAPQPTE ERLPSSPVYEDAASFKAELSYRGPV SGTEPEPVYSMEAADYREASSQQGL AYATEAVYESAEAPGHYPAEDSTYD EYENDLGITAVALYDYQAAGDDEIS FDPDDIITNIEMIDDGWWRGVCKGR YGLFPANYVELRQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
