| Description : |
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
83.9 kDa |
| AA Sequence : |
MWKASAGHAVSIAQDDAGADDWETD PDFVNDVSEKEQRWGAKTVQGSGHQ EHINIHKLRENVFQEHQTLKEKELE TGPKASHGYGGKFGVEQDRMDKSAV GHEYQSKLSKHCSQVDSVRGFGGKF GVQMDRVDQSAVGFEYQGKTEKHAS QKDYSSGFGGKYGVQADRVDKSAVG FDYQGKTEKHESQRDYSKGFGGKYG IDKDKVDKSAVGFEYQGKTEKHESQ KDYVKGFGGKFGVQTDRQDKCALGW DHQEKLQLHESQKDYSKGFGGKYGV QKDRMDKNASTFEDVTQVSSAYQKT VPVEAVTSKTSNIRANFENLAKEKE QEDRRKAEAERAQRMAKERQEQEEA RRKLEEQARAKTQTPPVSPAPQPTE ERLPSSPVYEDAASFKAELSYRGPV SGTEPEPVYSMEAADYREASSQQGL AYATEAVYESAEAPGHYPAEDSTYD EYENDLGITAVALYDYQAAGDDEIS FDPDDIITNIEMIDDGWWRGVCKGR YGLFPANYVELRQ |
| Applications : |
ELISA; WB-Re; AP; Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
