• Official Full Name

    dopamine receptor D1

  • Overview

    The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2 mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. Dopamine receptor D1 has been reported mostly in various regions of the brain. ESTs have been isolated from normal olfactory epithelium and cancerous genitourinary tract libraries.
  • Synonyms

    DRD1; dopamine receptor D1; DADR; DRD1A; D(1A) dopamine receptor; Dopamine D1 receptor; OTTHUMP00000161116;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRD1-12163H Recombinant Human DRD1, His-tagged E.coli His 338-446a.a.
Human DRD1-10H Recombinant Human DRD1 Wheat Germ N/A
Human DRD1-15H Recombinant Human DRD1 protein, His-tagged E.coli His Arg338~Thr446
Human DRD1-28086TH Recombinant Human DRD1, C-MYC-tagged MYC
Human DRD1-6818HCL Recombinant Human DRD1 293 Cell Lysate HEK293 N/A
Human DRD1-20HL Recombinant Human DRD1 HEK293T cell lysate HEK293T Myc/DDK
Human DRD1-6909HF Recombinant Full Length Human DRD1 Protein In Vitro Cell Free System 446 amino acids
Human DRD1-3647H Recombinant Human DRD1 protein, GST-tagged E.coli GST 338-446 aa
Human DRD1-1098HFL Recombinant Human DRD1 protein, His&Flag-tagged HEK293 His&Flag 1-446 aa
Human DRD1-1211H Recombinant Human DRD1 Full Length Transmembrane protein(VLPs) HEK293 N/A Met 1 - Thr 446
Mouse DRD1-1269M Recombinant Mouse DRD1 protein, His-GST-tagged E.coli His/GST Gln338~Thr446
Rat Drd1-1380R Recombinant Rat Drd1 Protein, His-tagged E.coli N-His Gln338-Thr446
Bos taurus (Bovine) RFL35702BF Recombinant Full Length Bovine D(1A) Dopamine Receptor(Drd1) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Homo sapiens (Human) RFL24292HF Recombinant Full Length Human D(1A) Dopamine Receptor(Drd1) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Macaca mulatta (Rhesus macaque) RFL32420MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) D(1A) Dopamine Receptor(Drd1) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Oryctolagus cuniculus (Rabbit) RFL28566OF Recombinant Full Length Rabbit D(1A) Dopamine Receptor(Drd1) Protein, His-Tagged E.coli expression system His Full Length (1-180)
Rattus norvegicus (Rat) RFL23445RF Recombinant Full Length Rat D(1A) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-446)
Rhesus Macaque DRD1-1329R Recombinant Rhesus monkey DRD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DRD1-1154R Recombinant Rhesus Macaque DRD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DRD1-1154R-B Recombinant Rhesus Macaque DRD1 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL17407SF Recombinant Full Length Pig D(1A) Dopamine Receptor(Drd1) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Xenopus laevis (African clawed frog) RFL8615XF Recombinant Full Length Xenopus Laevis D(1A) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-451)
Chicken DRD1-3904C Recombinant Chicken DRD1 Mammalian Cell His
Kit-1061 Lipoxygenase Activity Assay Kit (Fluorometric) N/A
Kit-1211 DRD1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1212 cAMP DRD1 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DRD1 involved in several pathways and played different roles in them. We selected most pathways DRD1 participated on our site, such as Alcoholism, Amine ligand-binding receptors, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsDRD1;DRD5;CHRM2;ADRB1;ADRA2C;CHRM3;ADRB2;CHRM4;ADRa1A
Class A/1 (Rhodopsin-like receptors)CCL27;PTGDR2;ADORA2B;CXCL11.8;ADRA2A;CYSLTR1;PNOCB;GPR31;FPR-RS6
Dopamine receptorsDRD1;DRD5;DRD4;DRD2;DRD3

DRD1 has several biochemical functions, for example, ATPase binding, D3 dopamine receptor binding, G-protein alpha-subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD1 itself. We selected most functions DRD1 had, and list some proteins which have the same functions with DRD1. You can find most of the proteins on our site.

Function Related Protein
D3 dopamine receptor bindingDRD1A;DRD1;CLIC6;PALM
G-protein alpha-subunit bindingRIC8;LPAR3;PPP5C;RGS19;RIC8A;CRHR1;HTR2A;F2RL1;F2R
G-protein coupled amine receptor activityDRD1;DRD1A;DRD5;DRD3;TAAR4;GPR21;TAAR7A;TAAR8B;GPR161
angiotensin receptor bindingARRB1;ARRB2;DRD1A;DRD1
dopamine bindingADRB2;DRD2B;DRD2L;GPR143;SLC6A3;TH;DRD2;DRD3;DRD2A
dopamine neurotransmitter receptor activityDRD4-RS;DRD4;DRD2L;DRD5;DRD1B;DRD1A;DRD7;DRD4A;DRD1
dopamine neurotransmitter receptor activity, coupled via GsDRD1A;DRD1B;DRD5;DRD1
protein heterodimerization activityKCNN1;HIST1H2BF;MYF5;UGT1A9;H2AFY;SNX2;HIST1H2AA;DMRT3A;SUPT4H1
protein phosphatase bindingJUP;CDC27;SKAP1;FLT4;MAP2K7;Itga10&Itgb1;STAT6;PIK3R2;PPARG

DRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD1.


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        Q&As (7)

        Ask a question
        How do genetic variations in DRD1 affect its function? 12/29/2022

        Genetic mutations in DRD1 can alter dopamine signaling and brain function.

        What role does DRD1 play in psychiatric disorders? 10/20/2022

        DRD1 is involved in various psychiatric and neurological disorders.

        How does DRD1 contribute to cognitive processes? 09/23/2021

        It significantly modulates cognitive abilities and behavior.

        What is the primary role of DRD1 in neurotransmission? 01/29/2020

        DRD1 is crucial for dopamine-mediated neurotransmission, influencing brain function.

        What potential therapeutic applications arise from targeting DRD1? 07/10/2019

        Targeting DRD1 offers therapeutic potential for neurological and psychiatric conditions.

        How does DRD1 interact with other dopamine receptors in the brain? 12/12/2018

        DRD1 works with other dopamine receptors, contributing to neural networks.

        What is the impact of altered DRD1 activity on dopamine signaling? 08/11/2017

        Changes in DRD1 activity disrupt normal dopamine signaling, affecting mental health.

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