DSP
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Official Full Name
desmoplakin -
Overview
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008] -
Synonyms
DSP;desmoplakin;DP;DPI;DPII;desmoplakin I;desmoplakin II;250/210 kDa paraneoplastic pemphigus antigen
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DSP-12182H | Recombinant Human DSP, GST-tagged | E.coli | Human | GST | 1-350a.a. | |
| DSP-1195H | Recombinant Human DSP Protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 78-300 a.a. |
|
| DSP-1381H | Recombinant Human DSP Protein (78-300 aa), His-tagged | Yeast | Human | His | 78-300 aa |
|
| DSP-401H | Recombinant Human DSP Protein, His-tagged | E.coli | Human | His | Phe2609~Ala2822 |
|
Involved Pathway
DSP involved in several pathways and played different roles in them. We selected most pathways DSP participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway,Apoptosis,Apoptotic cleavage of cell adhesion proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alpha6-Beta4 Integrin Signaling Pathway | EIF4EB,SMAD3B,NTN1A,CLCA1,EIF4E,CDKN1A,PLEC,DST,YWHAQ,MST1R |
| Apoptotic execution phase | PANK1A,HIST1H1B,SPNA2,GAS2,DFFA,CASP6L1,CASP6L2,CTNNB1,H1F0,PTBP3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DMD,ACTN1,ITGB1,CDH2,ITGA8,ITGA4,SGCB,ACTN4,LEF1,ITGB5 |
| Programmed Cell Death | STK24B,STK24,DIABLO,DBNLA,DBNLB,HMGB2A,DSG2,ADD1,Gzmg,CASP6L2 |
| Apoptosis | IRF4A,BIRC2,BADB,PANK1A,BID,PTBP3,PRKACB,IL3,DIABLOB,APAF1 |
| Apoptotic cleavage of cellular proteins | DSG2,DBNL,CASP6L2,PLEC,SATB1,STK24,PTBP3,PKP1,OCLN,DBNLA |
| Apoptotic cleavage of cell adhesion proteins | DSG2,CTNNB1,DSG1,PTBP3,CTNNB2,PKP1,DSG3,OCLN |
| Arrhythmogenic right ventricular cardiomyopathy | CTNNA2,DMD,CDH2,JUP,CACNG2,CACNG3,CTNNA1,DSC2,DAG1,DSG2 |
Protein Function
DSP has several biochemical functions, for example, cell adhesion molecule binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSP itself. We selected most functions DSP had, and list some proteins which have the same functions with DSP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase C binding | PARD3,TIRAP,PEA15A,HSPB1,SDPRA,PICK1,HINT1,MARCKS,FEZ1,CASQ2 |
| poly(A) RNA binding | SMNDC1,RPGR,PTBP2,SSB,RPL10A,SART3,SAP18,DAZAP1,CISD2,NAP1L4 |
| structural constituent of cytoskeleton | COX4I2,SPTBN1,TUBB2B,SORBS3,KRT5,TUBGCP5,SPTA1,ARPC2,INA,ARPC3 |
| structural molecule activity | INAA,KRT19,SNTA1,MAP7,CLDN7A,KRT28,NEFMA,FLG2,KRT27,KRT6A |
| protein binding, bridging | AMFR,TRIM22,TJP2,SLC9A1,VPS18,FGB,IVL,LOR,EVPL,RAD50 |
| scaffold protein binding | CAV2,NLGN4Y,NLRP1,ADCY6,CRIPT,HOMER1,MAPK3,NLGN4X,LRP4,KRT8 |
| cell adhesion molecule binding | PVRL1A,PVRL4,ITGB1,MSN,ADAM8,CD200,ITGAL,ITGB2,NLGN4Y,CD1D |
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | JUP,DSC2,CTNNA3,DSG2,PKP2 |
| protein binding | SETX,OXR1,ATG101,JDP2,MMP9,NOD1,CDK2,CENPJ,PIBF1,ZFP161 |
Interacting Protein
DSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSP here. Most of them are supplied by our site. Hope this information will be useful for your research of DSP.
MAPRE1;JUP;PKP2;q76353_9hiv1;PECAM1;NFKB2;PSTPIP1;SSSCA1
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References
- Paul, AJ; Schwab, K; et al. Direct analysis of mAb aggregates in mammalian cell culture supernatant. BMC BIOTECHNOLOGY 14:-(2014).
- Campbell, K; McNamee, SE; et al. Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:6867-6881(2014).
