dsp Protein, desmoplakin

dsp

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dsp

Official Full Name desmoplakin
Background Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
Synonyms DSP; desmoplakin; DP; DPI; DPII; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen;
    • Species :
    • Human
    • Source :
    • E.coli
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DSP-1381H Recombinant Human DSP Protein (78-300 aa), His-tagged Yeast His
    Human DSP-1195H Recombinant Human DSP Protein, His-SUMO-tagged E.coli His/SUMO
    Human DSP-12182H Recombinant Human DSP, GST-tagged E.coli GST
    Human DSP-401H Recombinant Human DSP Protein, His-tagged E.coli His

    dsp involved in several pathways and played different roles in them. We selected most pathways dsp participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cell adhesion proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with dsp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alpha6-Beta4 Integrin Signaling Pathway PLEC; DST; CD151L; EIF4EB; MST1R; NTN1A; EIF4EBP1; YWHAQ; COL17A1; CD151
    Apoptosis DFFB; NTRK1; STK24A; BID; HELLS; DBNLA; BADB; STK26; DAPK3; DCC
    Apoptotic cleavage of cell adhesion proteins OCLN; DSG3; DSP; PTBP3; CTNNB2; CTNNB1; DSG1; PKP1; DSG2
    Apoptotic cleavage of cellular proteins STK26; STK24; CASP6L2; CTNNB2; DBNLB; GAS2; DBNLA; PTBP3; CASP6L1; CTNNB1
    Apoptotic execution phase CTNNB1; PKP1; BCAP31; CTNNB2; SATB1; STK24B; OCLN; DBNLB; DSG3; HMGB2A
    Arrhythmogenic right ventricular cardiomyopathy DSC2; CACNG3; CTNNA1; CTNNA2; DSP; DES; DSG2; DAG1; JUP; CDH2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) LEF1; CACNG8; ITGA9; SGCB; ITGB6; CACNA2D2; ITGA7; ATP2A2; PKP2; ITGB7
    Programmed Cell Death PANK1A; BMX; DNM1L; DIABLOB; STK24; Gzmg; GZMC; STK24B; SATB1; PKP1

    dsp has several biochemical functions, for example, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dsp itself. We selected most functions dsp had, and list some proteins which have the same functions with dsp. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding PVRL1; ITGB3; PTBP3; CD1d1; ITGA4; CD226; CRTAM; CXADR; FGFR1; SDCBP
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication DSP; JUP; DSG2; PKP2; DSC2; CTNNA3
    poly(A) RNA binding NSUN2; RPS4X; SECISBP2; UBE2I; MRPS12; CSTF1; FNDC3A; GM5506; SUGP2; CCDC108
    protein binding SFRS9; RAB23; TEAD4; TBX18; VPS11; OSBPL2; NMB; RBM14; TRIM33; PHF16
    protein binding, bridging PPP2R3A; TCAP; FSCN3; FGA; CNTLN; COL1A2; COL8A2; STX1A; LOR; PPP4R2
    protein kinase C binding HDAC7; TIRAP; FLNA; AKT1; PLEK; C1QBP; SDPRB; MARCKS; CASQ2; TOP2B
    scaffold protein binding HOMER1; NOS3; NLGN4Y; SCN5A; SHANK1; NLRP1; CHRNA7; CACNA1H; NLGN4X; CHUK
    structural constituent of cytoskeleton NEFL; ARPC5; KRT6B; KRT14; CTNNA2; SYNM; TUBGCP3; ACTL7A; TUBA4L; TUBD1
    structural molecule activity MAP1B; KRT32; KRT4; LCE4A; MAP2; PNN; NGS; MAP7D2A; MAP4; IVL

    dsp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsp here. Most of them are supplied by our site. Hope this information will be useful for your research of dsp.

    MAPRE1; JUP; PKP2; q76353_9hiv1; PECAM1; NFKB2; PSTPIP1; SSSCA1

    Paul, AJ; Schwab, K; et al. Direct analysis of mAb aggregates in mammalian cell culture supernatant. BMC BIOTECHNOLOGY 14:-(2014).
    Campbell, K; McNamee, SE; et al. Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:6867-6881(2014).

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