DSP

  • Official Full Name

    desmoplakin
  • Overview

    Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
  • Synonyms

    DSP;desmoplakin;DP;DPI;DPII;desmoplakin I;desmoplakin II;250/210 kDa paraneoplastic pemphigus antigen
Cat.# Product name Source (Host) Species Tag Protein Length Price
DSP-12182H Recombinant Human DSP, GST-tagged E.coli Human GST 1-350a.a.
DSP-1195H Recombinant Human DSP Protein, His-SUMO-tagged E.coli Human His&SUMO 78-300 a.a.
DSP-1381H Recombinant Human DSP Protein (78-300 aa), His-tagged Yeast Human His 78-300 aa
DSP-401H Recombinant Human DSP Protein, His-tagged E.coli Human His Phe2609~Ala2822

    Involved Pathway

    DSP involved in several pathways and played different roles in them. We selected most pathways DSP participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway,Apoptosis,Apoptotic cleavage of cell adhesion proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB7,TCF7L2,ACTN1,ITGAV,ITGB1,ITGB5,CACNB2,ITGA4,EMD,CACNG3
    Apoptotic cleavage of cellular proteins SPNA2,PLECA,DSG3,CTNNB1,BMX,SATB1,LMNB1,PTBP3,DBNLB,STK24
    Apoptosis BCL2L11,LMNB1,HDR,HIST1H1B,CFLARA,DSG3,CDK5RAP2,BCL2L1,PIK3R1,BCL2A
    Programmed Cell Death CASP6L2,STK26,DSG3,ADD1,CASP6L1,BCAP31,HMGB2,DBNL,DNM1L,DBNLA
    Apoptotic execution phase HIST1H1B,HMGB2A,STK24,LMNB1,HIST1H1D,DSG3,PANK1A,DBNLA,CASP6L1,DFFA
    Apoptotic cleavage of cell adhesion proteins DSG2,OCLN,PTBP3,DSG3,DSG1,CTNNB2,CTNNB1,PKP1
    Alpha6-Beta4 Integrin Signaling Pathway RTKN,CDKN1A,YWHAQ,PLEC,EIF4EBP1,EIF4E,SMAD3B,CLCA1,EGFR,CD151L
    Arrhythmogenic right ventricular cardiomyopathy CACNG2,JUP,DSC2,CACNG3,DMD,CTNNA1,DES,CTNNA2,DSG2,CDH2

    Protein Function

    DSP has several biochemical functions, for example, cell adhesion molecule binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSP itself. We selected most functions DSP had, and list some proteins which have the same functions with DSP. You can find most of the proteins on our site.

    Function Related Protein
    protein binding, bridging TJP2,IVL,STUB1,NMD3,BFAR,VPS18,CUX1,EVPL,CSTA,CNKSR1
    structural molecule activity SPRR2G,CLDNA,BVES,LCE1F,EVPL,KRT40,KRT85,KRT6A,CLDN8,OC90
    poly(A) RNA binding ELAVL1,PSPC1,HIST2H4,ZFP579,EPPK1,RPS26,HMGB1,PRPF3,PEBP1,RSL1D1
    structural constituent of cytoskeleton SORBS2,TUBGCP4,SPTBN2,KRT14,EPB42,BKJ,YEATS4,TUBA8L3,TUBA4A,ARPC3
    protein kinase C binding SDPRB,TWF2,PARD6A,AVPR1B,PRKCSH,IRS1,FLNA,ADD3,GLRX3,SQSTM1
    cell adhesion molecule binding NLGN1,CPE,CXADR,ITGB1,TIGIT,NRXN1,PVR,LILRB2,PVRL3,NLGN4Y
    protein binding FBXW7,CIRH1A,LRRC29,HK2,MAL2,BMPR1AA,SDHB,DAXX,CTBP1,MIEF1
    scaffold protein binding CACNA1G,CAV2,SHANK1,KCNQ1,TREM1,NCK2,CACNA1H,NLGN3,CRIPT,DLG4
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication CTNNA3,DSC2,PKP2,JUP,DSG2

    Interacting Protein

    DSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSP here. Most of them are supplied by our site. Hope this information will be useful for your research of DSP.

    MAPRE1;JUP;PKP2;q76353_9hiv1;PECAM1;NFKB2;PSTPIP1;SSSCA1

    Resources

    References

    • Paul, AJ; Schwab, K; et al. Direct analysis of mAb aggregates in mammalian cell culture supernatant. BMC BIOTECHNOLOGY 14:-(2014).
    • Campbell, K; McNamee, SE; et al. Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:6867-6881(2014).

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