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DUSP1

Official Full Name

dual specificity phosphatase 1
Overview

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Synonyms

DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DUSP1-28071TH	Recombinant Human DUSP1	Wheat Germ	N/A	367 amino acids	$298 / 2ug
Human	DUSP1-852H	Recombinant Human DUSP1, His-tagged	E.coli	His		Inquiry
Human	DUSP1-32H	Recombinant Human DUSP1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DUSP1-01H	Recombinant Human DUSP1 protein, His-GST-tagged	E.coli	His-GST	Val175~Cys367	Inquiry
Human	DUSP1-1392H	Recombinant Human DUSP1 Protein, His-tagged	E.coli	N-His	Val175-Cys367	Inquiry
Human	DUSP1-130HF	Recombinant Full Length Human DUSP1 Protein	In Vitro Cell Free System		367 amino acids	Inquiry
Mouse	DUSP1-4874M	Recombinant Mouse DUSP1 Protein	Mammalian Cell	His		Inquiry
Mouse	DUSP1-2561M	Recombinant Mouse DUSP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	DUSP1-2561M-B	Recombinant Mouse DUSP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DUSP1-1347R	Recombinant Rhesus monkey DUSP1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DUSP1-1172R	Recombinant Rhesus Macaque DUSP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	DUSP1-1172R-B	Recombinant Rhesus Macaque DUSP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	DUSP1-12297Z	Recombinant Zebrafish DUSP1	Mammalian Cell	His		Inquiry
Chicken	DUSP1-3684C	Recombinant Chicken DUSP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	FGF20A;FGF18B;RASGRP1;EGFR;CSF2RB;PEA15A;JAK3;FRS2A;EGF
ATF-2 transcription factor network	ATF2;GADD45A;CBFB;CSRP2;KAT5;CDK4;DDIT3;JUN;JUND
Axon guidance	SEMA3C;RNF8;CNKSR1;CD24;RHOB;PPP3R2;JAK1;EFNA3B;AKAP9
Cytokine Signaling in Immune system	EIF4G2A;XAF1;CSH1;GBP6;SPTB;HBEGF;PEBP1;TRIM26;FRS2
DAP12 interactions	CSF2RB;DUSP6;SPNA1;AGO1;WDR83;NRG2A;TREM1;SIRPB1;GRAP2A
DAP12 signaling	DUSP6;FRS2;IL17RD;FGF18B;PTPRA;PHB;GRAP2B;FRS2A;KLB
Developmental Biology	EFNA3B;LAMTOR2;DUSP2;MED23;NRG4;SEMA3AB;POU5F3;MYL12A;DPYSL3
Direct p53 effectors	RNF144B;PCBP4;CEBPZ;SMARCA4;GADD45A;DDB2;EDN2;CCNK;CSE1L

DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.

Function	Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP10;CTDSPL2A;PTPRQ;DUSP7;DUSP6;SGPP2;SACM1LA;DUSP2;PXYLP1
non-membrane spanning protein tyrosine phosphatase activity	PTPN12;PTPN18;ACP1;PTPN11;PTPN9;PTPN4;DUSP1
protein binding	FARSA;KLHL20;DNAJB11;MSX2;AASDHPPT;SULT1B1;RAVER2;PTPN11;SUFU
protein tyrosine/serine/threonine phosphatase activity	TENC1;EYA3;DUSP5;DUSP8A;EPM2A;LRP8;CTDSPL2A;CDC14C;RNGTT
protein tyrosine/threonine phosphatase activity	SACM1LB;CTDSPL2B;CTDSPL2A;PTPRQ;NT5DC3;DUSP2;SACM1L;PXYLP1;SGPP2

DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.

MAPK3; MAPK14; MAPK1; SKP2; UBB

Research Area

Head and Neck Cancer Biomarkers

Phosphatases in the Akt Pathway

Phosphatases and Regulators

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).

Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).