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DUSP1

Official Full Name

dual specificity phosphatase 1
Overview

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Synonyms

DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E. coli
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DUSP1-28071TH	Recombinant Human DUSP1	Wheat Germ	N/A	367 amino acids	$298 / 2ug
Human	DUSP1-852H	Recombinant Human DUSP1, His-tagged	E.coli	His		Inquiry
Human	DUSP1-32H	Recombinant Human DUSP1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DUSP1-01H	Recombinant Human DUSP1 protein, His-GST-tagged	E. coli	His-GST	Val175~Cys367	Inquiry
Human	DUSP1-1392H	Recombinant Human DUSP1 Protein, His-tagged	E.coli	N-His	Val175-Cys367	Inquiry
Human	DUSP1-130HF	Recombinant Full Length Human DUSP1 Protein	In Vitro Cell Free System		367 amino acids	Inquiry
Mouse	DUSP1-4874M	Recombinant Mouse DUSP1 Protein	Mammalian Cell	His		Inquiry
Mouse	DUSP1-2561M	Recombinant Mouse DUSP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	DUSP1-2561M-B	Recombinant Mouse DUSP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DUSP1-1347R	Recombinant Rhesus monkey DUSP1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DUSP1-1172R	Recombinant Rhesus Macaque DUSP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	DUSP1-1172R-B	Recombinant Rhesus Macaque DUSP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	DUSP1-12297Z	Recombinant Zebrafish DUSP1	Mammalian Cell	His		Inquiry
Chicken	DUSP1-3684C	Recombinant Chicken DUSP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DUSP1 Related Articles
DUSP1 Related Research Area

DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	FRS3;KIDINS220B;PSMD9;DAB2IPB;SPRED2;SPTBN1;PSMD10;PEBP1;DUSP7
ATF-2 transcription factor network	JUNB;KCNA3;HRK;JDP2;JUND;CREB1;POU2F1;CBFB;MAPK14
Axon guidance	JAK2;GNAI1;AGRN;COL9A1A;NETO2;ITSN1;CRMP1;PAK4;COL6A1
Cytokine Signaling in Immune system	SPRED2;IFIT14;IRF2;TRIM29;TRIM14;EIF4E;LAMTOR2;NEFLB;UBE2V1
DAP12 interactions	PEBP1;SPRED2;GRAP2A;PAQR3A;FRS2;CSF2RA;PHB;AGO3;AGO1
DAP12 signaling	SPRED3;RASGEF1A;DUSP1;SPTBN2;KLB;AGO1;CSF2RA;DUSP7;THEM4
Developmental Biology	SEMA3AA;KALRN;DUSP7;DLG3;SCN3A;SPTB;KBTBD7;AP2M1;MED26
Direct p53 effectors	PRDM1;CEBPZ;DUSP5;EDN2;DUSP1;BCL2L14;GDF15;TRIAP1;DDX5

DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.

Function	Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP21;CTDSPL2A;PTPRQ;DUSP1;DUSP9;DUSP7;SGPP2;DUSP4;TENC1
non-membrane spanning protein tyrosine phosphatase activity	PTPN9;PTPN18;DUSP1;PTPN4;ACP1;PTPN11;PTPN12
protein binding	TRIM6;MYL12A;SGCA;YTHDC1;CRK;RASSF2;LRRC4C;CEBPB;SLC25A6
protein tyrosine/serine/threonine phosphatase activity	DUSP3;DUSP3B;DUSP8A;DUSP19A;CTDSPL2B;DUSP10;DUSP4;DUPD1;DUSP15
protein tyrosine/threonine phosphatase activity	DUSP4;DUSP1;SACM1LA;NT5DC3;TENC1;PXYLP1;SACM1LB;PTPRQ;CTDSPL2A

DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.

MAPK3; MAPK14; MAPK1; SKP2; UBB

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).

Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).

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