DUSP1

  • Official Full Name

    dual specificity phosphatase 1

  • Overview

    The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
  • Synonyms

    DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP1-28071TH Recombinant Human DUSP1 Wheat Germ N/A 367 amino acids
Human DUSP1-852H Recombinant Human DUSP1, His-tagged E.coli His
Human DUSP1-32H Recombinant Human DUSP1 protein, GST-tagged Wheat Germ GST
Human DUSP1-01H Recombinant Human DUSP1 protein, His-GST-tagged E.coli His-GST Val175~Cys367
Human DUSP1-1392H Recombinant Human DUSP1 Protein, His-tagged E.coli N-His Val175-Cys367
Human DUSP1-130HF Recombinant Full Length Human DUSP1 Protein In Vitro Cell Free System 367 amino acids
Mouse DUSP1-4874M Recombinant Mouse DUSP1 Protein Mammalian Cell His
Mouse DUSP1-2561M Recombinant Mouse DUSP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DUSP1-2561M-B Recombinant Mouse DUSP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DUSP1-1347R Recombinant Rhesus monkey DUSP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DUSP1-1172R Recombinant Rhesus Macaque DUSP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DUSP1-1172R-B Recombinant Rhesus Macaque DUSP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DUSP1-12297Z Recombinant Zebrafish DUSP1 Mammalian Cell His
Chicken DUSP1-3684C Recombinant Chicken DUSP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPTPRA;SPRED2;SPTB;AKAP9;CNKSR1;KIDINS220B;CSF2RA;PSMD10;SPTBN2
ATF-2 transcription factor networkCBFB;GADD45A;CDK4;KCNA3;MAPK14;JDP2;JUNB;DUSP10;JUN
Axon guidanceEFNA4;DPYSL4;AP2A2;EFNA1A;NFATC3;SPTA1;SCN3A;CAP1;PPP3CB
Cytokine Signaling in Immune systemLGALS9;ARIH1L;EIF4G1;SPTBN1;ARIH1;DUSP1;CNKSR1;PHB;DUSP2
DAP12 interactionsSPRED2;DUSP4;NRG3;MOV10;PHB;GRAP2B;PEBP1;SPTBN2;HBEGF
DAP12 signalingCSF2RA;FGF10B;MARK3;CSF2RB;DUSP2;FRS2;NRG3;RASGEF1A;RASGRP1
Developmental BiologySREBF2;MED29;DCC;SEMA4D;EZRA;LGI1;TCF4;GFRA4;DUSP2
Direct p53 effectorsSCN3B;S100A2;CEBPZ;NDRG1;CD82;CCNK;BCL2L14;DDB2;HIC1

DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activityNT5DC3;DUSP16;PXYLP1;DUSP2;DUSP5;SACM1LB;DUSP7;DUSP1;CTDSPL2B
non-membrane spanning protein tyrosine phosphatase activityPTPN4;PTPN18;PTPN11;PTPN12;PTPN9;DUSP1;ACP1
protein bindingFAM164C;IFNGR1;FSTL5;KCNH7;HOXB7;SNX6;SPEF1;PRRG2;TRAF2
protein tyrosine/serine/threonine phosphatase activityCDC14C;DUSP19B;DUSP8A;DUSP1;TPTE;DUSP2;DUSP14;DUSP26;DUSP4
protein tyrosine/threonine phosphatase activityCTDSPL2A;NT5DC3;DUSP1;CTDSPL2B;DUSP4;DUSP19;DUSP2;SGPP2;PTPRQ

DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.

MAPK3; MAPK14; MAPK1; SKP2; UBB

Research Area

Related articles

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).
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