Recombinant Full Length Human DUSP1 Protein

Cat.No. : DUSP1-130HF
Product Overview : Recombinant full length Human DUSP1 protein with an N terminal proprietary tag; predicted Mwt: 66.44 kDa inclusive of tag.
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Description : The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Source : In Vitro Cell Free System
Species : Human
Form : Liquid
Molecular Mass : 66.440kDa inclusive of tags
Protein Length : 367 amino acids
AA Sequence : MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP ITTSPSC
Purity : Proprietary Purification
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
Storage Buffer : pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.
Gene Name : DUSP1 dual specificity phosphatase 1 [ Homo sapiens ]
Official Symbol : DUSP1
Synonyms : DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP1
Gene ID : 1843
mRNA Refseq : NM_004417
Protein Refseq : NP_004408
MIM : 600714
UniProt ID : P28562

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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