EGR1 Protein


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Official Full Name early growth response 1
Background The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008]
Synonyms EGR1; early growth response 1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268; early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • His-B2M
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EGR1-52 Recombinant Human EGR1 protein, His-tagged E.coli His
    Human EGR1-2120H Recombinant Human Early Growth Response 1 Sf9 Insect Cell N/A
    Human EGR1-28467TH Recombinant Human EGR1 Wheat Germ N/A
    Human EGR1-3121H Recombinant Human EGR1 Protein, GST-tagged Wheat Germ GST
    Human EGR1-628H Recombinant Human EGR1 Protein, His-tagged E.coli His
    Mouse EGR1-5052M Recombinant Mouse EGR1 Protein Mammalian Cell His
    Mouse Egr1-629M Recombinant Mouse Egr1 Protein, His-tagged E.coli His
    Rat EGR1-2032R Recombinant Rat EGR1 Protein Mammalian Cell His
    Rhesus Macaque EGR1-1399R Recombinant Rhesus monkey EGR1 Protein, His-tagged Mammalian Cell His
    Chicken EGR1-5712C Recombinant Chicken EGR1 Mammalian Cell His
    Zebrafish EGR1-8845Z Recombinant Zebrafish EGR1 Mammalian Cell His
    Human EGR1-6692HCL Recombinant Human EGR1 293 Cell Lysate HEK293 N/A
    Human EGR1-2841H Recombinant Human EGR1 protein, His-B2M-tagged E.coli His-B2M
    Human EGR1-1384H Recombinant Human EGR1 Protein (444-543 aa), His-tagged Yeast His

    EGR1 involved in several pathways and played different roles in them. We selected most pathways EGR1 participated on our site, such as BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway CDK5; EIF4EBP1; FRS3; DOK5; CSNK2A1P; FRS2; KCNN2; GRIP1; BCL2L11; YBX1
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes IKZF1; CTLA4; CSF2; EGR1; EGR3; POU2F1; DGKA; EGR4; BATF3; EGR2
    Cytokine Signaling in Immune system FCGR1B; TRIM68; SPRED1; EIF4A2; ADAR; NEFLB; EIF4G2A; EDARADD; NUP50; GBP4
    Downstream signaling in naive CD8+ T cells EGR4; EOMES; EGR1; JUNB
    ErbB1 downstream signaling BAIAP2; EGR1; ABI1; WASF2; NCKAP1; MAP3K2; EPS8; ACTR3; ACTR2; ARF4
    Glucocorticoid receptor regulatory network KRT17; SMARCA4; EGR1; CSN2; POU2F1; BGLAP; SMARCC2; KRT14; KRT5; NR1I3
    HTLV-I infection XIAP; TBPL2; WNT9A; ETS1; RB1; PDGFB; IL15RA; WNT7B; TGFB3; CDC27
    Immune System AP1B1; NLRC5; TRIM46; CASPBL; TNIP2; IFI27; ERAP1; KIF4; TNFSF13B; CHST13

    EGR1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR1 itself. We selected most functions EGR1 had, and list some proteins which have the same functions with EGR1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SUB1A; Arid4b; DNASE1L3; OTPB; ZNF225; LTF; CHD9; TTF2; POLR2A; ZNF445
    RNA polymerase II core promoter sequence-specific DNA binding NLRC5; SP1; STAT5A; TFAP2B; H2AFY; TRP53; GATA3; MAZ; RREB1; FOS
    RNA polymerase II regulatory region sequence-specific DNA binding ZMYND11; CEBPB; ZFP39; ACTN4; ETV6; MEF2A; PHOX2B; TFAP2E; ATF5A; BARX2
    histone acetyltransferase binding TAF7; FOXP3; TP53; HIF1A; NR4A3; CEBPB; TRIM68; SIRT2; MEF2A; MYOCD
    metal ion binding VAV1; CYP2Y3; MUT; AGFG1A; ACLYA; ZNF133; SAP30; COL27A1; RXRBA; SPNA1
    protein binding SYNM; H2-AA; IKZF1; TMEM147; NLGN4Y; ASNS; GCA; CAMK2G; GYPB; SREBF1
    sequence-specific DNA binding MAFGB; HOXB10A; CEBPD; ESRRB; OTX1B; POU3F3; FOXI3B; ZNF323; PBX3B; ZNF500
    transcription factor activity, sequence-specific DNA binding TADA3; ZNF812; BCL3; TCF25; MYCL1; ZNF43; HOXC8A; ZNF615; HOXB7; RCAN1
    transcription factor binding Ar; HEYL; JUNB; JUNBA; HDAC9; HHEX; TBP; SOST; SOX17; GCM1
    transcription regulatory region sequence-specific DNA binding ARNTL1A; NR5A5; HIF1AL; NFE2L3; NR5A1; EPAS1B; FOXJ1; ATF3; TBX18; NR5A1B
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HIF1A; EBF2; TFE3; FOXL2; SIX2; NEUROG3; PATZ1; SMAD2; EPAS1; NR4A3

    EGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR1.

    CDKN2A; CTNNB1; SNAI1; SP1; SUMO1; SREBF2; nos; astD; MAGEB2; MED6; DNAJC8

    Vogels, RJC; Vlenterie, M; et al. Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases. DIAGNOSTIC PATHOLOGY 9:-(2014).
    Prast, JM; Schardl, A; et al. Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).

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