Recombinant Mouse Ercc8 Protein, His&GST-tagged

• Cat.No.: Ercc8-1437M
• Product Overview: Recombinant Mouse Ercc8 Protein (Met1-Gly397) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within response to UV and response to X-ray. Predicted to be located in cytoplasm; nuclear matrix; and perikaryon. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit).
• Source: E. coli
• Species: Mouse
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 73.7 kDa
  Accurate Molecular Mass: 74 kDa
• Protein length: Met1-Gly397
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Ercc8 excision repaiross-complementing rodent repair deficiency, complementation group 8 [ Mus musculus (house mouse) ]
• Official Symbol: Ercc8
• Synonyms: ERCC8; excision repaiross-complementing rodent repair deficiency, complementation group 8; DNA excision repair protein ERCC-8; Cockayne syndrome 1 homolog; cockayne syndrome WD repeat protein CSA homolog; Csa; Ckn1; 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik
• Gene ID: 71991
• mRNA Refseq: NM_028042
• Protein Refseq: NP_082318
• UniProt ID: Q8CFD5