Recombinant Human ERCC8 Protein, GST-tagged

• Cat.No.: ERCC8-3463H
• Product Overview: Human ERCC8 full-length ORF (AAH09793.1, 1 a.a. - 205 a.a.) recombinant protein with GST tag at N-terminal.

Specification

• Description: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 48.29 kDa
• AA Sequence: MLGFLSARQTGLEDPLRLRRAESTR RVLGLELNKDRDVERIHGGGINTLD IEPVEGRYMLSGGSDGVIVLYDLEN SSRQSYYTCKAVCSIGRDHPDVHRY SVETVQWYPHDTGMFTSSSFDKTLK VWDTNTLQTADVFNFEETVYSHHMS PVSTKHCLVAVGTRGPKVQLCDLKS GSCSHILQGIFILFQTATTLSKRFN KKKRY
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 [ Homo sapiens ]
• Official Symbol: ERCC8
• Synonyms: ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA; CKN1
• Gene ID: 1161
• mRNA Refseq: NM_000082
• Protein Refseq: NP_000073
• MIM: 609412
• UniProt ID: Q13216