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Official Full Name FBJ murine osteosarcoma viral oncogene homolog
Background The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Synonyms FOS; FBJ murine osteosarcoma viral oncogene homolog; p55; AP-1; C-FOS; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOS-4893H Recombinant Human FOS Protein, His-tagged E. coli His
    Human FOS-26602TH Recombinant Human FOS, GST-tagged Sf9 Insect Cell GST
    Human FOS-27240TH Recombinant Human FOS, His-tagged His
    Human FOS-32H Recombinant Human FOS protein, GST-tagged Wheat Germ GST
    Human FOS404H Recombinant Human FOS Protein, His-tagged E.coli His
    Human FOS-4846H Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog, GST-tagged Sf9 Insect Cell GST
    Human FOS-6168HCL Recombinant Human FOS 293 Cell Lysate HEK293 N/A
    Mouse FOS-5971M Recombinant Mouse FOS Protein Mammalian Cell His
    Mouse Fos-6775M Recombinant Mouse Fos protein, His & GST-tagged E.coli His/GST
    Rat FOS-2380R Recombinant Rat FOS Protein Mammalian Cell His
    Rhesus Macaque FOS-1738R Recombinant Rhesus monkey FOS Protein, His-tagged Mammalian Cell His
    Chicken FOS-7057C Recombinant Chicken FOS Mammalian Cell His
    Zebrafish FOS-11611Z Recombinant Zebrafish FOS Mammalian Cell His

    fos involved in several pathways and played different roles in them. We selected most pathways fos participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with fos were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway IKBKB; MAPK7; TAOK3; CACNA1SB; FAS; RPS6KA5; FGF18; RELB; DUSP8A; SRF
    cAMP signaling pathway LOC100328615; ATP2A2; CNGA1; SLC9A1; CREB3L1; PIK3CD; GLI3; HTR1B; PDE4A; RAC1
    Osteoclast differentiation CSF1R; IL1B; LILRA1; PIK3R1; TGFB1; PIK3CD; MAPK11; TRAF2; IFNGR2; NOX1
    Toll-like receptor signaling pathway IRAK1; MAPK14B; IFNPHI1; TLR1LB; PIK3R5; TLR5; RIPK1; IFNA3; SPP1; RELA
    T cell receptor signaling pathway PRKCQ; LCK; PAK3; PPP3CB; MAP2K2; Il2; VAV1; PAK7; PIK3R3; NFATC2
    B cell receptor signaling pathway PIK3CG; NFKBIB; RAC1; NFATC1; CDK6; PIK3R3; CR2; PLEKHA1; CRK; CSK
    TNF signaling pathway NFKB1; MAPK3; RELA; RPS6KA5; CCL2; PIK3CG; CASP8; MAP3K5; MAP2K6; MAPK12
    Circadian entrainment KCNJ5; GRIN2B; RYR1; GNG8; CALM1; GRIN2A; GNB2; ITPR1; CAMK2G; GNG11
    Cholinergic synapse ATF4; CHRM2; PIK3R5; GNA11; GNB2; GNG8; KCNJ4; PIK3CB; GNAQ; ACHE
    Dopaminergic synapse KIF5B; DRD5; PPP1CA; DRD4; PPP2R5C; ITPR3; PPP2CA; PPP2R5D; GNG13; CREB3
    Estrogen signaling pathway FKBP5; GNAO1; HSP90AA1; CALM1; PRKACA; GNAS; PIK3CA; AKT2; HSPA6; PIK3R5
    Prolactin signaling pathway PPIB; LHCGR; TNFSF11; SHC2; STAT3; SHC3; PIK3R5; TH; SLC2A2; FOXO3
    Oxytocin signaling pathway MYLK; GNAI1; MYLK4; EEF2K; CALM2; GNAS; RHOA; ROCK2; FOS; PRKAB1
    Amphetamine addiction CREB3L3; CREB3L4; GRIA4; PRKCG; GRIN3A; CALM2; CALML3; PRKACA; CAMK2G; ATF4
    Salmonella infection DYNC1I2A; MAPK12; MAPK12A; TJP1; MAPK11; MYH9; MAPK3; CCL4L2; PFN2L; MAPK14A
    Pertussis IL6; C1QB; MAPK9; TICAM2; C1QC; GM5077; C1RA; ITGB2L; FOS; CFL2
    Chagas disease (American trypanosomiasis) PLCB1; PPP2R2D; CCL3L1; CASP8; PPP2CB; IFNGR1; CCL2; IRAK1; MYD88; PPP2R2C
    Hepatitis B TICAM2; TGFB1; MMP9; EGR3; PIK3CD; TLR3; CCNA2; IFNA13; FADD; Ifna11
    HTLV-I infection VDAC3; WNT3; MAP3K1; PPP3R1; CCND2; CREM; RB1; IL15; IL2RG; WNT11
    Herpes simplex infection IKBKG; PER2; EEF1D; PER1B; TAP1; CLOCKB; Ifna11; LTA; MAP3K7; IFNA21
    Pathways in cancer BMP2; IL6; CTNNA3; AKT1; DAPK1; WNT11; TCEB2; ARNT2; Flt3l; GLI2
    Colorectal cancer MAPK9; TP53; PIK3CG; APC; TGFB1; TRP53; SMAD4; SMAD3; BAX; KRAS
    Choline metabolism in cancer PLA2G4B; WASL; PLCG1; DGKZ; MAPK8; PDGFC; SOS1; GRB2; EIF4EBP1; PLA2G4C
    Rheumatoid arthritis CXCL6; H2-AB1; ATP6V0A1; CXCL12; Ctsl; IL6; TEK; FOS; ICAM1; VEGFA

    fos has several biochemical functions, for example, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fos itself. We selected most functions fos had, and list some proteins which have the same functions with fos. You can find most of the proteins on our site.

    Function Related Protein
    R-SMAD binding PPM1A; SMAD4; C18orf1; MEN1; PARP1; TRIM33; PAX6; SMAD6; MYOCD; JUN
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CEBPZ; NFATC2; RBPJL; CTCF; JUN; ZIC3; MAFA; SOX1; ZNF257; ZGPAT
    RNA polymerase II core promoter sequence-specific DNA binding SP3; TAL1; H2AFZ; HOXB3; H3F3A; ZFPM1; SOX3; GBX2; EP300; RBPJ
    chromatin binding TPR; DNMT3B; KLF6A; HCFC1; MECP2; PROP1; NCAPD2; FEZF2; PARP1; ISL1
    protein binding FAM46B; STYK1; AGER; SHC1; ITGA6; MAP3K5; SLC26A3; MLC1; TRAF3IP3; ELF2
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding JDP2; MSX2; CLOCK; FOSL2; IRF7; FOSB; BATF; HIST2H3A; RBPJL; ARNTL
    transcription factor activity, sequence-specific DNA binding GLI2; CDX2; NR5A1B; KAT7A; FOXN2B; ATF5; PCGF2; ZFP14; ALS2CR8; NOTCH1
    transcription factor binding GPX3; HES1; SMARCD3; SOX8; Trl; TRIB1; NFATC4; THRA; NAB2; ETS1
    transcription regulatory region DNA binding ASH2L; H2AFY2; NKX2-5; HIVEP2A; TAF9; SFPQ; GLIS2; ZNF831; CTCF; HNF4A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NFAT5; PAX8; ATF2; STAT3; KLF4; FOXJ2; MITFB; RFX4; GMEB1; SOX11

    fos has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fos here. Most of them are supplied by our site. Hope this information will be useful for your research of fos.


    Ming, J; Zhang, QF; et al. Anti-Lymphangiogenesis Effects of a Specific Anti-Interleukin 7 Receptor Antibody in Lung Cancer Model In Vivo. MOLECULAR CARCINOGENESIS 54:148-155(2015).
    Fahrenkrug, J; Falktoft, B; et al. Phosphorylation of Rat Melanopsin at Ser-381 and Ser-398 by Light/Dark and Its Importance for Intrinsically Photosensitive Ganglion Cells (ipRGCs) Cellular Ca2+ Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 289:35482-35493(2014).

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