GRB10

  • Official Full Name

    growth factor receptor-bound protein 10

  • Overview

    Growth factor receptor-bound protein 10 and the insulin-like growth factor and the extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways in HEK 293T cells,In vivo. However, many aspects of the Grb10 adapter function remain unclear. Further research is still required to elucidate and validate the interactions and effects of GRB10 with various cellular targets.
  • Synonyms

    GRB10; growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRB10-1856H Recombinant Human GRB10, GST-tagged E.coli GST
Human GRB10-13518H Recombinant Human GRB10, GST-tagged E.coli GST 1-80a.a.
Human GRB10-751HCL Recombinant Human GRB10 cell lysate N/A
Human GRB10-2233H Recombinant Human GRB10 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GRB10-246H Recombinant Human GRB10 Protein, His-tagged E.coli His Thr392~Leu594
Human GRB10-5227H Recombinant Human GRB10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GRB10-5035H Recombinant Human GRB10 Protein, GST-tagged Wheat Germ GST
Human GRB10-5319HF Recombinant Full Length Human GRB10 Protein, GST-tagged In Vitro Cell Free System GST 536 amino acids
Human GRB10-4702H Recombinant Human GRB10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GRB10-3564H Recombinant Human GRB10 protein, His-tagged E.coli His 208-536 aa
Mouse GRB10-7245M Recombinant Mouse GRB10 Protein Mammalian Cell His
Mouse Grb10-1053M Recombinant Mouse Grb10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse GRB10-3913M Recombinant Mouse GRB10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GRB10-3913M-B Recombinant Mouse GRB10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GRB10-1970R Recombinant Rhesus monkey GRB10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GRB10-1791R-B Recombinant Rhesus Macaque GRB10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GRB10-1791R Recombinant Rhesus Macaque GRB10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GRB10-3345C Recombinant Chicken GRB10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRB10 Related Articles
  • GRB10 Related Signal Pathway

GRB10 involved in several pathways and played different roles in them. We selected most pathways GRB10 participated on our site, such as EGFR1 Signaling Pathway, IGF1 pathway, IRS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EGFR1 Signaling PathwayCEBPA;CEACAM1;EPPK1;SH2D3C;EEF1A1;ABI1B;GRB7;KRT8;SH3BGRL
IGF1 pathwayGNB2L1;GRB10
IRS activationGRB10A;GRB10
Insulin PathwayGRB14;GRB10;EXOC1;EXOC5;DOK1;EXOC3;EXOC6
Insulin SignalingREG1A;SNAP25A;MINK1;STXBP3;SGK2;FLOT1;MAP3K9;GSK3AB;ARHGAP33
Insulin receptor signalling cascadeLAMTOR1;C7orf59;GRB10;GRB10A;RRAGB;RRAGA
Kit Receptor Signaling PathwayGRAPA;PTPRU;STAP1;GRB10;SOCS4;SPRED2B;GRB7;PTPRUB;DOK1B
PDGFR-beta signaling pathwaySLA;GRB10;SLC9A3R1;SNX15;DOK1

GRB10 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB10 itself. We selected most functions GRB10 had, and list some proteins which have the same functions with GRB10. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityCRK;FCRL2;LAT;CHN1;PAG1;GRB7;GRB10;SH3BGR;ARHGAP1
insulin receptor bindingINS2;PIK3R1;SHC1;SNX1;PHIP;DOK5;INSL3;FRS2A;IGF1R
protein bindingTEC;DHX16;TRPC6;H3F3B;LRP4;SGPL1;POU5F1;GLI2;RINL

GRB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB10.

EGFR; INSR; RCAN3; IGF1R; EPHB1; BAIAP2; ABI1; GRB2; ZDHHC17; NOA1

Gorlova, O; Martin, JE; et al. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLOS GENETICS 7:-(2011).
Higashi, S; Iseki, E; et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. JOURNAL OF NEUROCHEMISTRY 115:423-437(2010).
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