GRB10

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GRB10

Official Full Name growth factor receptor-bound protein 10
Background Growth factor receptor-bound protein 10 and the insulin-like growth factor and the extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways in HEK 293T cells,In vivo. However, many aspects of the Grb10 adapter function remain unclear. Further research is still required to elucidate and validate the interactions and effects of GRB10 with various cellular targets.
Synonyms GRB10; growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRB10-13518H Recombinant Human GRB10, GST-tagged E.coli GST
    Human GRB10-1856H Recombinant Human GRB10, GST-tagged E.coli GST
    Human GRB10-2233H Recombinant Human GRB10 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GRB10-246H Recombinant Human GRB10 Protein, His-tagged E.coli His
    Human GRB10-4702H Recombinant Human GRB10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GRB10-5035H Recombinant Human GRB10 Protein, GST-tagged Wheat Germ GST
    Human GRB10-5227H Recombinant Human GRB10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GRB10-751HCL Recombinant Human GRB10 cell lysate N/A
    Mouse Grb10-1053M Recombinant Mouse Grb10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse GRB10-7245M Recombinant Mouse GRB10 Protein Mammalian Cell His
    Rhesus Macaque GRB10-1970R Recombinant Rhesus monkey GRB10 Protein, His-tagged Mammalian Cell His
    Chicken GRB10-3345C Recombinant Chicken GRB10 Mammalian Cell His

    GRB10 involved in several pathways and played different roles in them. We selected most pathways GRB10 participated on our site, such as EGFR1 Signaling Pathway, IGF1 pathway, IRS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EGFR1 Signaling Pathway TNK2; REPS2; EPPK1; ABI1B; RALBB; RGS16; CEACAM1; PTK6; PITPNAA; ABI1
    IGF1 pathway GRB10; GNB2L1
    IRS activation GRB10A; GRB10
    Insulin Pathway EXOC3; EXOC1; EXOC5; DOK1; GRB10; GRB14; EXOC6
    Insulin Signaling ARHGAP33; EHD1; FLOT1; STXBP2; STXBP1A; MAP4K1; RHOJ; MAPK4; REG1A; SGK2
    Insulin receptor signalling cascade GRB10A; RRAGA; GRB10; LAMTOR1; C7orf59; RRAGB
    Kit Receptor Signaling Pathway STAP1; PTPRUB; DOK1; SOCS4; DOK1B; GRB7; PTPRU; GRAP; GRAPA; GRB10
    PDGFR-beta signaling pathway SLA; SNX15; DOK1; GRB10; SLC9A3R1

    GRB10 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB10 itself. We selected most functions GRB10 had, and list some proteins which have the same functions with GRB10. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity SH2D3A; GRB14; NCK1; SHB; IRS4; SKAP2; HSH2D; CRK; STAP1; RUSC1
    insulin receptor binding DOK4; SNX2; IRS2; DOK1B; PHIP; IGF1R; SHC1; IGF1; INS; ENPP1
    protein binding VRK1; DIS3L2; MRFAP1L1; CNO; NIF3L1; SPAG8; CTNNAL1; APLP1; KRT4; TBP

    GRB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB10.

    EGFR; INSR; RCAN3; IGF1R; EPHB1; BAIAP2; ABI1; GRB2; ZDHHC17; NOA1

    Gorlova, O; Martin, JE; et al. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLOS GENETICS 7:-(2011).
    Higashi, S; Iseki, E; et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. JOURNAL OF NEUROCHEMISTRY 115:423-437(2010).

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