GRB10 involved in several pathways and played different roles in them. We selected most pathways GRB10 participated on our site, such as EGFR1 Signaling Pathway, IGF1 pathway, IRS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| EGFR1 Signaling Pathway |
APPL2; GRB14; STXBP1A; KRT17; CEBPA; RGS5B; KRT7; PTPN12; KLF11; KRT8 |
| IGF1 pathway |
GNB2L1; GRB10 |
| IRS activation |
GRB10A; GRB10 |
| Insulin Pathway |
EXOC6; GRB14; EXOC5; DOK1; EXOC3; GRB10; EXOC1 |
| Insulin Signaling |
GRB10; STXBP3A; STXBP3; CAP1; RRAD; KIF5B; ARHGAP33; STXBP2; MAP3K2; MAP3K9 |
| Insulin receptor signalling cascade |
LAMTOR1; RRAGB; RRAGA; GRB10; C7orf59; GRB10A |
| Kit Receptor Signaling Pathway |
DOK1; STAP1; GRB7; GRAP; SPRED2B; SOCS4; PTPRU; DOK1B; GRAPA; PTPRUB |
| PDGFR-beta signaling pathway |
DOK1; GRB10; SNX15; SLA; SLC9A3R1 |
GRB10 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB10 itself. We selected most functions GRB10 had, and list some proteins which have the same functions with GRB10. You can find most of the proteins on our site.
| Function |
Related Protein |
| SH3/SH2 adaptor activity |
LASP1; PTPN11; SH2D2A; NCK1; ARHGAP1; HSH2D; CHN2; LAT; SRC; GRB7 |
| insulin receptor binding |
IGF1R; IRS1; DOK3; DOK6; DOK4; DOK2; DOK1B; DOK7; IRS4; INS2 |
| protein binding |
LARP4; DYNLL1; AGPAT5; KIF6; HUS1; MECP2; SLC30A3; PRKRIP1; NT5C2; FGFR2 |
GRB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB10.
EGFR; INSR; RCAN3; IGF1R; EPHB1; BAIAP2; ABI1; GRB2; ZDHHC17; NOA1
Gorlova, O; Martin, JE; et al. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLOS GENETICS 7:-(2011).
Higashi, S; Iseki, E; et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. JOURNAL OF NEUROCHEMISTRY 115:423-437(2010).
