Recombinant Human GRB10, GST-tagged

• Cat.No.: GRB10-1856H
• Product Overview: Recombinant human GRB10 protein(637-926) with N-terminal GST tag was expressed inE.coliexpression system, MW=60.3 kDa.

Specification

• Cat. No.: GRB10-1856H
• Description: Growth factor receptor-bound protein 10 is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors.
• Source: E.coli.
• Purity: 90%.
• Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
• Specific Activity: 4.6 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 37ºC. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at –80°C.

Gene Information

• Gene Name: GRB10 growth factor receptor-bound protein 10 [ Homo sapiens ]
• Synonyms: growth factor receptor-bound protein 10; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207; GRB10; OTTHUMP00000197989; OTTHUMP00000197994; OTTHUMP00000197993;OTTHUMP00000197990; GRBIR;OTTHUMP00000197991; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR
• Gene ID: 2887
• mRNA Refseq: NM_001001549
• Protein Refseq: NP_001001549
• MIM: 601523
• UniProt ID: Q13322
• Chromosome Location: 7p12-p11.2
• Function: SH3/SH2 adaptor activity; insulin receptor binding; protein binding