grb2 Protein, growth factor receptor-bound protein 2


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Official Full Name growth factor receptor-bound protein 2
Background The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His/GST
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRB2-001H Recombinant Human GRB2 Protein, His-GST-tagged E.coli His/GST
    Human GRB2-002H Recombinant Human GRB2 Protein, His-tagged E.coli His
    Mouse Grb2-1054M Recombinant Mouse Grb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human GRB2-127H Recombinant Human GRB2 protein, T7/His-tagged E.coli T7/His
    Human GRB2-13520H Recombinant Human GRB2, GST-tagged E.coli GST
    Human GRB2-28345TH Recombinant Human GRB2, His-tagged E.coli His
    Human GRB2-28483TH Recombinant Human GRB2 E.coli N/A
    Human GRB2-435H Recombinant Human GRB2 protein, His-tagged HEK293F His
    Human GRB2-4847H Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged E.coli GST
    Human GRB2-500H Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged E.coli His
    Human GRB2-5038H Recombinant Human GRB2 Protein, GST-tagged Wheat Germ GST
    Human GRB2-5248H Recombinant Human GRB2 Protein, GST/His-tagged E.coli GST/His
    Human GRB2-5755HCL Recombinant Human GRB2 293 Cell Lysate HEK293 N/A
    Rat GRB2-2686R Recombinant Rat GRB2 Protein Mammalian Cell His
    Cynomolgus Monkey GRB2-565C Recombinant Cynomolgus GRB2 Protein, His-tagged Mammalian Cell His
    Chicken GRB2-5981C Recombinant Chicken GRB2 Mammalian Cell His

    grb2 involved in several pathways and played different roles in them. We selected most pathways grb2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with grb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway ELK1; RPS6KB2; MAP2K1; GSK3B; ERBB4A; NCK1; NCK2; PRKCBA; ERBB4; PAK2A
    Ras signaling pathway RASSF1; RAP1B; PRKACA; BRAP; Pdgfa&Pdgfb; SHOC2; PIK3CD; ARF6; HRAS; PTPN11
    Chemokine signaling pathway CCL22; GM10591; BCAR1; CCL1; PARD3; VAV1; GM1987; RAC1; AKT2; CCL17
    FoxO signaling pathway FOXO3A; GRB2A; MAPK1; FBXO25; PRKAB1A; KLF2A; MDM2; SOD2; S1PR1; MAPK12
    Phospholipase D signaling pathway AGTR1A; ARF6; FCER1A; KIT; GNAS; AVP; PIP5K1A; PLCB2; RALB; RAF1
    PIK-Akt signaling pathway LAMA2; PPP2R5E; LAMB1; FGF14; COL6A5; MET; TSC1; VEGFA; IFNA12; ITGB6
    Dorso-ventral axis formation SPIRE2; ETS1; NOTCH1A; CPEB3; SPIRE1; PIWIL4; CPEB1A; GRB2B; ETV7; NOTCH1B
    Osteoclast differentiation LCK; TREM2; LILRA1; LILRA3; IKBKB; TYROBP; SOCS3; SQSTM1; RELB; MAPK8
    Focal adhesion ACTN3B; BADB; COL2A1; LAMA1; ITGB5; MYLK3; SHC4; BCL2A; LAMA5; TNR
    Signaling pathways regulating pluripotency of stem cells SOX2; OTX1; LEFTY2; FGFR4; ACVR2B; GRB2; PIK3CB; FGFR2; KLF4; FZD9
    Jak-STAT signaling pathway IL21R; CCND2A; STAT2; SOCS1A; LEPB; IFNA2; AKT2; LEP; IL11; LIFR
    Natural killer cell mediated cytotoxicity TNFRSF10C; FCER1G; NRAS; PPP3R2; IFNA4; TNFSF10; RAET1G; VAV3; RAC1; HLA-A
    T cell receptor signaling pathway PAK6; PAK2; PPP3R1; NFKBIB; BCL10; DBNLB; ICOS; PDCD1; PDPK1; FYN
    B cell receptor signaling pathway DOK1; PILRB; CD19; CDK6; PPP3CB; IGHM; NFATC1; MAP2K1; DUSP6; HRAS
    Fc epsilon RI signaling pathway TNF; PLA2G4A; MAP2K7; MAPK12; PIK3R2; GAB2; GM-CSF; LYN; PDPK1; PLA2G4F
    Neurotrophin signaling pathway MAPK12; RAPGEF1; RAP1B; BDNF; NTRK3; RAC1; CAMK2G; ZFP110; PLCG2; MAPK8
    Insulin signaling pathway PIK3R3; HK3; INPPL1A; PHKG1B; KRAS; INPPL1; EIF4E1C; HRAS; PRKACBB; G6PCA.1
    GnRH signaling pathway CAMK2G; HBEGFA; CAMK2B1; KRAS; CALML5; CALM2; MAP2K4A; MAP2K4B; CAMK2D; HRASA
    Estrogen signaling pathway GNAI1; MMP2; MMP9; GNAI3; CREB5; RAF1; ATF6B; KCNJ9; HSPA6; HSPA1L
    Prolactin signaling pathway PRP2; MAPK10; FOS; SOS1; PIK3CB; PRLR; PIK3CG; NEK3; MAPK12; TH
    Alcoholism HIST1H2AA; HIST1H4K; GM14477; HIST1H2BB; H3F3B; HDAC2; GNAO1; GNAI1; GNG2; GNG10
    Hepatitis C CLDN15; PDPK1; TRAF6; IRF1; SOCS3; PPP2R2B; CLDN17; OAS1A; CLDN3; OSTN
    Pathways in cancer FGF6; FGF20; ROCK1; BIRC5; EPAS1; FGF5; WNT2B; PTGER4; Flt3l; CASP9
    Viral carcinogenesis TTC6; BAK1; HIST1H4J; DNAJA3; PIK3CG; TRAF1; HLA-E; TP53; HDAC7A; HIST1H2BB
    Proteoglycans in cancer ANK2; RAC1; HSPG2; PTCH1; WNT7A; SDC2; SDC1; ITPR1; RAF1; HCLS1
    MicroRNAs in cancer EP300; CDCA5; TRP53; RPS6KA5; ATM; ZEB2; PIM1; TP53; IGF2BP1; MDM2
    Renal cell carcinoma MAP2K2; PIK3R1; VHL; BRAF; FLCN; EP300; PIK3CD; HIF1A; TCEB1; ARNT
    Endometrial cancer ILK; GSK3B; AKT1; MLH1; PIK3CA; MAP2K1; PIK3CD; PIK3CB; MAP2K2; PIK3R3
    Glioma PRKCG; RB1; MAP2K2; MAPK1; CALM3; CALML3; Pdgfa&Pdgfb; GRB2; IGF1; IGF1R
    Prostate cancer BCL2; PIK3R5; IGF1R; TCF7; TCF7L2; LEF1; NKX3-1; NFKBIA; PIK3CB; PDGFRB
    Chronic myeloid leukemia SHC4; IKBKG; RELA; CRKL; CTBP2; CCND1; CBLC; STAT5B; SMAD4; PIK3R3
    Acute myeloid leukemia KIT; STAT5B; IKBKB; SPI1; FLT3; BRAF; RAF1; PIM2; PIK3R5; AKT3
    Non-small cell lung cancer RARB; PIK3CB; FHIT; TP53; ERBB2; HRAS; MAPK1; PLCG2; PIK3R1; STK4
    Choline metabolism in cancer DGKB; PLA2G4B; DGKE; EGF; PIK3CA; PIK3CB; PDGFRB; MAPK8; LYPLA1; RALGDS

    grb2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by grb2 itself. We selected most functions grb2 had, and list some proteins which have the same functions with grb2. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding HCLS1; DOCK4; SH3BP5LA; INPPL1B; CD2AP; EVLB; PLSCR4; ILK; WIPF3; DPYSL3
    SH3/SH2 adaptor activity RUSC1; GRAP; BLNK; NCK2; GAB1; GRB10; ITSN2; IRS4; SKAP1; SLA2
    ephrin receptor binding PIK3CG; EFNA3B; EFNB1; FYN; CBL; EFNB2B; EFNA2A; EPHA7; EFNA5; PTPN1
    epidermal growth factor receptor binding SHC1; Fert2; YES1; EGF; AREG; ERBB4; HBEGF; SOCS5; EFEMP1; CBLC
    identical protein binding ESR1; MUL1A; CRYAB; GRIK5; TNN; KHDC1A; RASSF1; GCG; NCL; LECT2
    insulin receptor substrate binding INSRA; GRB2; INSR; PRKCZ; IGF1RB; PTPN11; JAK2; INSRB; PRKCD; IGF1RA
    neurotrophin TRKA receptor binding PLCG1; SHC1; FRS2; GRB2; NGFR; EFNA5; PIK3R1
    phosphotyrosine binding CBLC; ZAP70; FGR; CBL; PTPN3; LDLRAP1; GRB2; CBLB; MAPK1; MAPK3
    poly(A) RNA binding IFI16; NOP2; DDX6; MYEF2; MRPL39; EIF2AK2; TDRD9; RPL24; RDBP; DDX54
    protein binding NLRX1; PIKFYVE; ETV5; STT3A; ANTXR2; DNER; ECT2; BRCA2; BAP1; SORCS1
    protein kinase binding PRC1; FAM83B; JTB; AP2A2; PRKRIP1; PTEN; STX1B; PRKAG1; TEX14; MS4A2
    protein phosphatase binding FLT4; ANAPC4; ITGA1; ANAPC5; GRB2; IRS2; PPME1; STAT3; TRP53; MAP2K7

    grb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of grb2.


    Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
    Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).

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