GRB2

  • Official Full Name

    growth factor receptor-bound protein 2

  • Overview

    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • No tag
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRB2-127H Recombinant Human GRB2 protein, T7/His-tagged E.coli T7/His
Human GRB2-4847H Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged E.coli GST
Human GRB2-13520H Recombinant Human GRB2, GST-tagged E.coli GST 1-214a.a.
Human GRB2-435H Recombinant Human GRB2 protein, His-tagged HEK293F His Met1~Val217
Human GRB2-28345TH Recombinant Human GRB2, His-tagged E.coli His
Human GRB2-5248H Recombinant Human GRB2 Protein, GST/His-tagged E.coli GST/His
Human GRB2-28483TH Recombinant Human GRB2 E.coli N/A
Human GRB2-500H Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged E.coli His
Human GRB2-5755HCL Recombinant Human GRB2 293 Cell Lysate HEK293 N/A
Human GRB2-5038H Recombinant Human GRB2 Protein, GST-tagged Wheat Germ GST
Human GRB2-001H Recombinant Human GRB2 Protein, His-GST-tagged E.coli His/GST 1-217
Human GRB2-0074H Recombinant Human GRB2 Protein (E2-V217), His tagged E.coli His E2-V217
Human GRB2-1017H-B Recombinant Human GRB2 Protein Pre-coupled Magnetic Beads HEK293
Human GRB2-1171HFL Recombinant Full Length Human GRB2 Protein, C-Flag-tagged Mammalian cells Flag
Human GRB2-151H Recombinant Human GRB2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human GRB2-3062H Recombinant Human GRB2 Protein (Met1-Val217), C-His tagged E.coli C-His Met1-Val217
Human GRB2-1017H Recombinant Human GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GRB2-002H Recombinant Human GRB2 Protein, His-tagged E.coli His 1-217
Human GRB2-0073H Recombinant Human GRB2 Protein (E2-V217), Tag Free E.coli No tag E2-V217
Human GRB2-5320HF Recombinant Full Length Human GRB2 Protein, GST-tagged In Vitro Cell Free System GST 217 amino acids
Mouse Grb2-1054M Recombinant Mouse Grb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat GRB2-2686R Recombinant Rat GRB2 Protein Mammalian Cell His
Rat GRB2-2340R Recombinant Rat GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRB2-2340R-B Recombinant Rat GRB2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GRB2-565C Recombinant Cynomolgus GRB2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GRB2-311C Recombinant Cynomolgus Monkey GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GRB2-311C-B Recombinant Cynomolgus Monkey GRB2 Protein Pre-coupled Magnetic Beads HEK293
Chicken GRB2-5981C Recombinant Chicken GRB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • GRB2 Related Signal Pathway

GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNB2;CACNG7A;GADD45B;HRASA;Fasl;PPP3CB;CDC42L;PPM1BB;BDNF
ErbB signaling pathwayMAP2K7;CAMK2G;ERBB3B;MAP2K4A;PIK3R3;AREGB;GRB2;CAMK2D;ERBB4A
Ras signaling pathwayGNG8;INS1;FGF1;PIK3CG;PIK3CB;KSR1;FGF10;VEGFB;MAPK8
Chemokine signaling pathwayGNG5;PIK3CA;CCL4L1;PAK1;VAV3;IL-8;NCF1;JAK3;VAV2
FoxO signaling pathwayEP300;USP7;HOMER3;SMAD3A;INSB;GRB2B;PRKAG3;HRAS;G6PC3
Phospholipase D signaling pathwayCXCR2;SPHK1;PIP5K1A;RAF1;PIK3R2;PLD2;GRM2;PLCG2;MAP2K2
PIK-Akt signaling pathwayFGF8;ITGB6;TRP53;Fasl;MDM2;GNB1;FGF1;VEGFC;RPS6KB2
Dorso-ventral axis formationGRB2;SOS1;MAPK3;NOTCH4;ETV7;CPEB2;CPEB1A;KRAS;NOTCH1B
Osteoclast differentiationFYN;AKT2;GRB2;GAB2;LCP2;FCGR3A;BTK;CYBB;SOCS3
Focal adhesionCOL27A1B;PARVG;FLT4;RAC1;PTK6;RHOB;CAPN2L;ITGA10;CCND2
Gap junctionDRD2A;TUBA4A;NRAS;GRB2B;GNAIA;HTR2C;PRKACG;TUBA7L;TUBA1L
Signaling pathways regulating pluripotency of stem cellsPCGF5;NANOG;WNT5A;FZD8;MAPK1;ID2;FGF2;PIK3R2;PIK3R3
Jak-STAT signaling pathwayCSH1;IFNPHI3;IL-15RA;GHRA;Il23a; Il12b;IFNPHI1;SOS1;CCND1;PTPN11A
Natural killer cell mediated cytotoxicityMAP2K1;PPP3CC;IFNB1;IFNA16;PPP3CA;Raet1c;KLRK1;ULBP2;KLRD1
T cell receptor signaling pathwayLCP2;PLCG1;PPP3CC;LAT;CD8B;NCK2;ICOS;MAP3K14;IKBKB
B cell receptor signaling pathwayAKT2;IFITM1;RELA;BANK1;PDK2B;CD79A;PTPN18;CD81;PPP3R1
Fc epsilon RI signaling pathwayGRB2;LAT;MAP2K1;MAPK12;MAPK13;PRKCA;RAC2;MAP2K3;RAC1
Neurotrophin signaling pathwayNTF4;MAP2K1;SHC4;CAMK2B;MAPKAPK2;Fasl;BAX;SHC3;MAP2K2
Insulin signaling pathwayG6PC;CALM4;ACACB;KRAS;FLOT1B;MAP2K2A;PRKACBB;INSR;PPP1CB
GnRH signaling pathwayADCY1A;MAPK8A;PRKACBB;PRKCD;MAPK1;PRKACG;CAMK2D1;PRKCBB;MAP2K2
Estrogen signaling pathwayCALML5;KCNJ5;PIK3CA;PRKACA;SHC2;CALM2;CALM4;HRAS;CALM1
Prolactin signaling pathwayPPIB;MAPK12;MAPK13;GSK3B;SOCS2;HRAS;ELF5;SHC1;SOCS7
AlcoholismSHC2;CALM1;HIST1H2BN;HDAC2;CAMK4;HIST1H2AD;HIST1H2AL;CREB3L3;H2AFV
Hepatitis CCLDN6;PPARA;IFNA17;IFNA12;IFNA13;OCLN;CLDN17;IFNA7;RNASEL
Hepatitis BFASLG;PRKCG;NFATC1;IFNA8;STAT1;IFNA12;FOS;MAP2K2;TLR3
Pathways in cancerIKBKG;SMAD2;BDKRB1;FGF12;ERBB2;FADD;AGTR1B;CTBP2;PIK3R2
Viral carcinogenesisKRAS;KAT2A;HIST1H4F;CCND2;HIST1H4E;PXN;HDAC4;HIST2H4;HDAC3
Proteoglycans in cancerPRKCG;PRKACA;BRAF;PPP1CC;TRP53;ANK1;PIK3CG;RAF1;FAS
MicroRNAs in cancerHNRNPK;PDGFRA;MET;ZEB2;BMPR2;MDM4;MDM2;PLAU;PLCG1
Renal cell carcinomaHGF;ARNT2;AKT2;MAPK3;PAK2;MET;PIK3CB;SOS1;HIF1A
Endometrial cancerPIK3R5;GRB2;GSK3B;PIK3CB;PIK3CD;CCND1;APC2;PTEN;CDH1
GliomaCAMK2D;PLCG1;AKT2;PIK3CG;RB1;MAPK1;CAMK2A;PDGFRA;PRKCB
Prostate cancerPIK3CA;NRAS;MAPK1;NFKBIA;IKBKB;SPRY1;CREB3L1;ATF4;NFKB1
Chronic myeloid leukemiaTGFB1;AKT2;SHC1;TGFBR2;TRP53;MECOM;BRAF;PIK3R3;SHC4
Acute myeloid leukemiaKRAS;MAP2K2;NFKB1;PIK3CA;CEBPA;MYC;RUNX1;RUNX1T1;STAT5B
Non-small cell lung cancerMAPK3;RXRG;PLCG2;MAP2K2;KRAS;RXRA;FHIT;RARB;PIK3R3
Choline metabolism in cancerSLC22A5;DGKE;WAS;PLA2G4C;AKT2;PCYT1A;PIP5K1C;RPS6KB2;DGKD

GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingSGIP1;MYPN;ADAM19;PAK3;INPPL1B;SHANK2;ARHGAP17;FMN1;CABYR
SH3/SH2 adaptor activitySTAM;PAG1;LAT;EPS8;NCK2;SLA;BLNK;SRC;ARHGAP1
ephrin receptor bindingEFNA5B;SDCBP;SRC;EFNB2B;NTRK3;Anks1;GRB2;SHC1;EPHA7
epidermal growth factor receptor bindingPLSCR1;SNX2;EGF;LINGO1;HBEGFB;CBLC;ATXN2;MS4A1;SOCS5
identical protein bindingDNMT3A;LEPR;PTPRG;EPS15;PCM1;CDC42;ENTPD2;SIRT1;UBE4A
insulin receptor substrate bindingJAK2;INSRA;GRB2;IGF1RB;IGF1RA;IGF1R;INSRB;PRKCZ;PIK3CB
neurotrophin TRKA receptor bindingGRB2;NGFR;EFNA5;SHC1;PLCG1;PIK3R1;FRS2
phosphotyrosine bindingLDLRAP1;STAP1;SHC1;MAPK1;ACP2;PTPN3;CBL;GRB2;CBLB
poly(A) RNA bindingMRM1;DYNC1LI1;RPL7;PNO1;RBM4;CD3EAP;RPL28;MKI67IP;FAM133B
protein bindingBCL2A1A;MYOM1;ATP6V1D;C5orf13;RPGRIP1L;AHCY;CCDC59;IPO13;THRAP3
protein kinase bindingSLC12A7;NIPAL1;CSPG4;DUSP3;SPAG16;TBL2;PTPN1;TRPV4;BCL10
protein phosphatase bindingCDC27;PPP1R3C;GNB2L1;ANAPC5;CSK;VCAN;PPARG;ERBB2;KCNN4

GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.

EGFR

Research Area

Related articles

Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All GRB2 Products

Required fields are marked with *

My Review for All GRB2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends