• Official Full Name

    growth factor receptor-bound protein 2

  • Background

    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • GST|His
    • His
    • His (Fc)
    • Avi
    • MYC
    • DDK
    • N/A
    • No tag
    • T7|His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken GRB2-5981C Recombinant Chicken GRB2 Mammalian Cell His
    Cynomolgus Monkey GRB2-565C Recombinant Cynomolgus GRB2 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey GRB2-311C Recombinant Cynomolgus Monkey GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey GRB2-311C-B Recombinant Cynomolgus Monkey GRB2 Protein Pre-coupled Magnetic Beads HEK293
    Human GRB2-4847H Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged E.coli GST
    Human GRB2-001H Recombinant Human GRB2 Protein, His-GST-tagged E.coli His/GST
    Human GRB2-435H Recombinant Human GRB2 protein, His-tagged HEK293F His
    Human GRB2-1017H-B Recombinant Human GRB2 Protein Pre-coupled Magnetic Beads HEK293
    Human GRB2-5248H Recombinant Human GRB2 Protein, GST/His-tagged E.coli GST/His
    Human GRB2-151H Recombinant Human GRB2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human GRB2-002H Recombinant Human GRB2 Protein, His-tagged E.coli His
    Human GRB2-5755HCL Recombinant Human GRB2 293 Cell Lysate HEK293 N/A
    Human GRB2-5038H Recombinant Human GRB2 Protein, GST-tagged Wheat Germ GST
    Human GRB2-13520H Recombinant Human GRB2, GST-tagged E.coli GST
    Human GRB2-28483TH Recombinant Human GRB2 E.coli N/A
    Human GRB2-28345TH Recombinant Human GRB2, His-tagged E.coli His
    Human GRB2-1017H Recombinant Human GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human GRB2-127H Recombinant Human GRB2 protein, T7/His-tagged E.coli T7/His
    Human GRB2-500H Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged E.coli His
    Human GRB2-0073H Recombinant Human GRB2 Protein (E2-V217), Tag Free E.coli No tag
    Human GRB2-0074H Recombinant Human GRB2 Protein (E2-V217), His tagged E.coli His
    Mouse Grb2-1054M Recombinant Mouse Grb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat GRB2-2340R Recombinant Rat GRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat GRB2-2686R Recombinant Rat GRB2 Protein Mammalian Cell His
    Rat GRB2-2340R-B Recombinant Rat GRB2 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GRB2 Related Articles
    • GRB2 Related Research Area
    • GRB2 Related Signal Pathway

    GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayIKBKG;MAPK8IP3;FGFR4;C11orf52;CACNA2D4;HSPA1L;CD14;TGFBR1A;TGFB2
    Ras signaling pathwayRAPGEF5;IGF1R;PLA2G2E;FGF6;EFNA4;BAD;Kitl;GNGT1;FGFR4
    Chemokine signaling pathwayCCL27;VAV3;SHC2;PRKCB;CCR6;CCL3;CCL21B;GRK1;XCR1
    FoxO signaling pathwayPCK2;PIK3R5;PLK1;BCL6A;PTENB;IKBKB;PIK3R3;PIK3R3A;PLK4
    Phospholipase D signaling pathwayMTOR;RAF1;LPAR6;CXCR1;PDGFRB;PLA2G4D;GRM8;MAPK3;RALGDS
    PIK-Akt signaling pathwayGNG3;ATF4;VEGFB;HSP90AB1;NOS3;TCL1B;GNG8;TEK;BRCA1
    Dorso-ventral axis formationCPEB3;CPEB4;NOTCH4;ETV6;ETS2;GRB2A;NOTCH1B;NOTCH1;PIWIL1
    Osteoclast differentiationSOCS1;PIK3R1;FCGR3B;LILRA1;MAPK10;NFKB2;FOS;TAB2;LILRA4
    Signaling pathways regulating pluripotency of stem cellsWNT2;ZFHX3;GSK3B;BMPR1B;WNT3A;FGFR4;ESX1;ACVR1B;BMPR2
    Jak-STAT signaling pathwayCSF3R;IL13;GRB2B;GFAP;IFNPHI3;IL15RA;IL21R.1;TP-1;STAT1
    Natural killer cell mediated cytotoxicityRaet1a;CD247;KIR2DS2;VAV3;Ifna11;Raet1c;VAV1;KLRK1;LCP2
    T cell receptor signaling pathwayMAP3K7;MAP2K1;MAP2K2;CD3E; CD3D;KRAS;LCK;MAPK13;CD8B1;PPP3CB
    B cell receptor signaling pathwayLIME1;CD19;IFITM1;VAV2;BCL10;CD79B;INPP5D;KRAS;RASGRP3
    Fc epsilon RI signaling pathwayMAPK8;PIK3R2;PLA2G4B;SOS1;PLA2G4F;TNF;PIK3CA;MAP2K1;PIK3R5
    Neurotrophin signaling pathwayYWHAE;RAP1A;NFKB1;RAC1;NGF;HRAS;PIK3CB;NTF4;MAPK10
    Insulin signaling pathwayPYGMA;INS2;INPPL1;TRIP10;PKLR;PRKAR1A;CALML5;EIF4EA;LIPE
    Estrogen signaling pathwayCREB5;SHC3;HSPA1A;PIK3CA;FKBP4;PRKACB;MAP2K1;CREB3L2;CREB3L3
    Prolactin signaling pathwaySOCS3;SOCS6;MAPK3;FOXO3;CSN2;INS;SIRPA;AKT2;ELF5
    Pathways in cancerFOS;CCNE1;PTGER3;RALBP1;GNAI2;GNGT2;MET;LPAR4;CUL2
    Proteoglycans in cancerCAMK2A;MAP2K2;THBS1;PLCG1;CD44;ACTB;MAPK3;EZR;HIF1A
    Renal cell carcinomaFLCN;EP300;PAK2;RAPGEF1;ARNT2;MAP2K1;RAC1;RAF1;GRB2
    Endometrial cancerTCF7L2;AKT2;PIK3CD;MLH1;GRB2;GSK3B;AKT1;KRAS;APC2
    Prostate cancerMAPK3;GSK3B;GRB2;PIK3R1;NDRG1;HSP90AB1;CPN1;FGFR2;INSRR
    Chronic myeloid leukemiaGRB2;CRKL;TGFB2;KRAS;RUNX1;IKBKG;CCND1;PIK3CD;TGFB1
    Acute myeloid leukemiaFLT3;PIK3R5;RPS6KB2;PPARD;CEBPA;PML;KRAS;RUNX1;PIK3R1
    Non-small cell lung cancerPIK3R2;TGFA;MAP2K1;PLCG2;NRAS;AKT2;BAD;PRKCG;PIK3CG
    Choline metabolism in cancerPLA2G4F;MAPK3;PPAP2A;PLD2;DGKE;SLC22A1;PLA2G4B;MAPK1;PRKCG

    GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activitySLA2;LAT;ARHGAP4;SRC;GRB14;SH2B2;PTPN11;GRB2;IRS4
    ephrin receptor bindingSDCBP;EFNA3B;CHN1;SHC1;CBL;EFNA3;NTRK3;EFNA4;EFNA5B
    epidermal growth factor receptor bindingSNX4;SHC1;ATXN2;EGF;SOCS5;VAV2;SNX2;FAM83B;AGR2
    identical protein bindingBCL2;LRRK2;VPS41;AMELX;ANXA4;TRIP10;C1QTNF2;CIDEB;DACT3
    insulin receptor substrate bindingIGF1RB;PIK3R1;PIK3CA;PRKCZ;INSR;IGF1RA;INSRB;INSRA;GRB2
    neurotrophin TRKA receptor bindingPIK3R1;EFNA5;GRB2;NGFR;PLCG1;FRS2;SHC1
    phosphotyrosine bindingACP2;CBL;PTPN3;SHC1;CBLB;ZAP70;MAPK1;GRB2;FGR
    protein bindingRPL15;SLC1A2;CDK5;DVL2;FBP2;CCNG1;GAPDH;SEC14L4;PFN1
    protein kinase bindingAPC;PAX6;GYS1;MAVS;EEF1A2;PLK1;PDPK1;CDKN2A;VDAC1
    protein phosphatase bindingSTAT6;EGFR;EIF2AK3;HSP90B1;TRP53;SKAP1;VRK3;GRB2;IRS2

    GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.


    Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
    Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).
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