GRB2 Protein


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Official Full Name growth factor receptor-bound protein 2
Background The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His/GST
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRB2-127H Recombinant Human GRB2 protein, T7/His-tagged E.coli T7/His
    Human GRB2-13520H Recombinant Human GRB2, GST-tagged E.coli GST
    Human GRB2-28345TH Recombinant Human GRB2, His-tagged E.coli His
    Human GRB2-28483TH Recombinant Human GRB2 E.coli N/A
    Human GRB2-435H Recombinant Human GRB2 protein, His-tagged HEK293F His
    Human GRB2-4847H Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged E.coli GST
    Human GRB2-500H Recombinant Human Growth Factor Receptor-bound Protein 2, His-tagged E.coli His
    Human GRB2-5248H Recombinant Human GRB2 Protein, GST/His-tagged E.coli GST/His
    Rat GRB2-2686R Recombinant Rat GRB2 Protein Mammalian Cell His
    Cynomolgus Monkey GRB2-565C Recombinant Cynomolgus GRB2 Protein, His-tagged Mammalian Cell His
    Chicken GRB2-5981C Recombinant Chicken GRB2 Mammalian Cell His
    Human GRB2-5755HCL Recombinant Human GRB2 293 Cell Lysate HEK293 N/A
    Human GRB2-151H Recombinant Human GRB2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human GRB2-5320HF Recombinant Full Length Human GRB2 Protein, GST-tagged In Vitro Cell Free System GST
    Human GRB2-001H Recombinant Human GRB2 Protein, His-GST-tagged E.coli His/GST
    Human GRB2-002H Recombinant Human GRB2 Protein, His-tagged E.coli His
    Human GRB2-5038H Recombinant Human GRB2 Protein, GST-tagged Wheat Germ GST
    Mouse Grb2-1054M Recombinant Mouse Grb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway GADD45BB; MAP4K1; PPM1NB; PLA2G4A; NR4A1; NFATC3; GRB2B; PPM1A; ARRB2; NLK
    ErbB signaling pathway NRG1; ERBB4A; BADB; PRKCA; HBEGFB; PIK3R3A; ERBB4; AKT2L; ABL2; AKT1
    Ras signaling pathway ARF6; PLA2G12A; KSR1; ELK1; PDGFRA; RASA4; IGF1R; ABL1; PLA2G5; TBK1
    Chemokine signaling pathway PIK3CD; CRK; AMCF-II; CXCL14; PIK3R3; PRKCZ; HRAS; GM13304; STAT5B; PF4
    FoxO signaling pathway PRKAB2; HOMER3; PRKAG2; FOXO6; GADD45AB; FOXO1A; CDKN1BA; SLC2A4; AKT1; MAPK11
    Phospholipase D signaling pathway PLD1; GRM6; SOS1; DNM3; PIK3R3; Kitl; MAP2K2; PPAP2A; RALB; PIK3CA
    PIK-Akt signaling pathway GH2; NGF; RELA; FGF6; TEK; LAMA1; GNG12; LPAR4; ITGA9; TLR4
    Dorso-ventral axis formation ETV6; SPIRE1; ETV7; PIWIL2; CPEB1; PPP1R2P9; NOTCH3; NOTCH1B; PIWIL4; GRB2A
    Osteoclast differentiation RAC1; LILRB3; PIK3R5; FCGR1A; NOX1; LILRA1; CSF1R; BTK; NOX3; PPP3CB
    Focal adhesion ZYX; ACTG1; ITGB1; MYL12.2; IGF1RB; COL6A6; MAPK8B; CDC42L; ACTN1; PDPK1B
    Gap junction GNAI2A; GRB2; GNA15.4; GJA1; PDGFRA; LPAR1; TUBAL3; CX43; RAF1A; GNAI1
    Signaling pathways regulating pluripotency of stem cells WNT9A; IL6ST; FGF2; INHBB; AKT1; WNT4; BMI1; WNT2B; NODAL; SMAD4
    Jak-STAT signaling pathway LIF; IL21R.1; MYCB; PTPN11B; PIAS4A; CISHB; LEPR; IL4; IL24; CTF1
    Natural killer cell mediated cytotoxicity KIR2DS3; PIK3R5; ULBP3; TYROBP; MAP2K1; PIK3CA; FAS; KIR2DS4; RAET1G; IFNA13
    T cell receptor signaling pathway PPP3R1; TEC; PAK2; CBLC; PIK3R3; PIK3R2; PTPN6; LCP2; SLA1; CD3E; CD3D
    B cell receptor signaling pathway CSK; ARPC1B; ITPR2; GSK3AB; ARPC4; CDK4; ACTR2; IKBKB; BCL2L11; CARD11
    Fc epsilon RI signaling pathway IL3; PLA2G4C; VAV2; MAPK3; MAPK1; MAP2K6; MAP2K7; HRAS; PIK3CA; PIK3R3
    Neurotrophin signaling pathway KIDINS220; GRB2; MAP3K3; PSEN1; SORT1; IRS1; ARHGDIB; BCL2; SHC3; RPS6KA5
    Insulin signaling pathway TSC1; FOXO1B; PRKAR1B; G6PCA.1; SOCS3B; IRS1; RPS6KB1; MAPK3; FBP2; PRKACBB
    GnRH signaling pathway SOS1; MAP2K4A; PRKCDA; PRKCBB; CALM1; GNRH3; GNAS; HBEGFA; RAF1; CAMK2B
    Estrogen signaling pathway PIK3R3; HSPA1L; ITPR1; SHC2; PRKACB; SRC; GPR30; PLCB3; GNAI1; PIK3CA
    Prolactin signaling pathway MAPK3; PRLR; SIRPA; TH; SHC1; STAT3; HRAS; MAPK12; PIK3CA; GRB2
    Hepatitis C IFNA10; MAVS; MAPK3; CLDN8; CLDN7; CLDN9; PPP2R2D; GSK3B; CLDN11; IFNA1
    Hepatitis B CCNE1; TRP53; STAT3; KRAS; TGFBR1; TGFB1; Fasl; CASP10; EGR3; PIK3CD
    Pathways in cancer FGF11; PLCB1; MSH6; CDH1; FGFR3; Fgf15; FGF10; LAMA3; F2R; BDKRB1
    Viral carcinogenesis GTF2A1; VAC14; PIK3R1; HIST1H2BD; HIST1H2BA; SCIN; CCND1; HIST1H2BM; NRAS; TP53
    Proteoglycans in cancer ERBB4; MMP9; PRKACA; PIK3CB; COL21A1; PXN; TLR2; IL12B; WNT9B; CAV3
    MicroRNAs in cancer EP300; SLC7A1; MAP2K2; PDGFA; APC; EZH2; RHOA; PIK3R2; HOXD10; PLCG2
    Renal cell carcinoma PIK3CG; VHL; KRAS; ETS1; TGFB2; PAK2; PIK3CA; SOS1; FH; TCEB2
    Endometrial cancer TP53; APC; TRP53; PIK3R2; MAP2K1; MLH1; ERBB2; BAD; LEF1; AKT1
    Prostate cancer MDM2; PDGFD; LEF1; CPN1; SOS1; PIK3CB; PIK3R1; NRAS; SPINK1; RELA
    Chronic myeloid leukemia HDAC1; STAT5B; MAP2K2; AKT2; SHC1; SOS1; TGFBR2; RUNX1; NFKB1; GRB2
    Acute myeloid leukemia EIF4EBP1; TCF7; KRAS; RPS6KB2; MAP2K2; RUNX1T1; GRB2; MYC; PIK3CA; PIK3R3
    Non-small cell lung cancer PDPK1; ALK; RASSF1; RXRA; AKT1; RXRB; GRB2; PIK3CG; ERBB2; PRKCA
    Choline metabolism in cancer PDGFD; PIK3CB; DGKQ; SLC44A2; PPAP2C; Pdgfa&Pdgfb; PDGFB; LYPLA1; TSC2; PDPK1

    GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding PARK2; ABI2; EVLB; NOXA1; EPS15; ARHGAP17; SH3BGRL; DPYSL3; RAD9A; SH3BP5
    SH3/SH2 adaptor activity PAG1; SH2D2A; HSH2D; GRB10; NCK1; SH3BGRL; ARHGAP1; NCK2; STAP1; SLA
    ephrin receptor binding EPHA4; SHC1; CHN1; EFNB2A; EFNA2; EFNA1; EFNA1A; CDK5; ANKS1B; EFNB2B
    epidermal growth factor receptor binding CBLC; ARF4; EFEMP1; PLSCR1; EREG; YES1; SNX2; TGFA; SHC1; FAM83B
    identical protein binding KCTD13; ANXA4; DDX58; AMELX; ACADM; GRASP; TPCN2; AKT1; BNIP3; ATG16L1
    insulin receptor substrate binding INSRA; JAK2; INSRR; PTPN11; PIK3CB; IGF1RA; INSRB; IGF1R; PIK3CA; PRKCD
    neurotrophin TRKA receptor binding GRB2; NGFR; PLCG1; EFNA5; PIK3R1; FRS2; SHC1
    phosphotyrosine binding ZAP70; MAPK1; CBL; LDLRAP1; SHC1; CBLC; PTPN3; SAMSN1; ACP2; STAP1
    poly(A) RNA binding LBR; RBM28; GRB2; H2-Q10; ERAL1; RBM47; CISD2; ABT1; HNRNPF; XRN2
    protein binding CDK16; SRPX2; HTRA3; ADAM9; MYB; ARMC2; RAB10; PAK3; STK38L; APOBEC3F
    protein kinase binding B4GALT1; CNPPD1; CALM1; PRKAG2; FBXW5; LIPE; RNF138; PRKAB1; ATF2; CALM2
    protein phosphatase binding TRP53; ITPR1; VCAN; VRK3; ANAPC5; PPME1; PPARG; MVP; KCNN4; DLG4

    GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.


    Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
    Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).

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