Recombinant Full Length Human GRB2 Protein, GST-tagged

• Cat.No.: GRB2-5320HF
• Product Overview: Human GRB2 full-length ORF ( AAH00631, 1 a.a. - 217 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 49.61 kDa
• Protein Length: 217 amino acids
• AA Sequence: MEAIAKYDFKATADDELSFKRGDIL KVLNEECDQNWYKAELNGKDGFIPK NYIEMKPHPWFFGKIPRAKAEEMLS KQRHDGAFLIRESESAPGDFSLSVK FGNDVQHFKVLRDGAGKYFLWVVKF NSLNELVDYHRSTSVSRNQQIFLRD IEQVPQQPTYVQALFDFDPQEDGEL GFRRGDFIHVMDNSDPNWWKGACHG QTGMFPRNYVTPVNRNV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GRB2 growth factor receptor-bound protein 2 [ Homo sapiens ]
• Official Symbol: GRB2
• Synonyms: GRB2; growth factor receptor-bound protein 2; NCKAP2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2; ASH; Grb3-3; MST084; MSTP084; EGFRBP-GRB2
• Gene ID: 2885
• mRNA Refseq: NM_002086
• Protein Refseq: NP_002077
• MIM: 108355
• UniProt ID: P62993