Hrh1
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Official Full Name
histamine receptor H1
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Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
HRH1; histamine receptor H1; histamine H1 receptor; H1R; HisH1; Histamine receptor subclass H1; HH1R; OTTHUMP00000160133; OTTHUMP00000207582; OTTHUMP00000207583; OTTHUMP00000209395; histamine H(1) receptor; histamine receptor, subclass H1; H1-R;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Bovine
- Cavia porcellus (Guinea pig)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Guinea pig
- Guinea Pig
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Pan troglodytes (Chimpanzee)
- Pongo pygmaeus (Bornean orangutan)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Flag
- N
- C
- Myc
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Hrh1 involved in several pathways and played different roles in them. We selected most pathways Hrh1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CALM3;TACR3;PLCG1;SLC25A31;CALM3B;ATP2B2;ITPKC;ADCY2B;GNA14 |
| Neuroactive ligand-receptor interaction | GALR2;TRHR2;CHRNA2;GABRB1;NR3C1;GRIA3A;PRLHR2A;CHRNA7;P2RY8 |
| Inflammatory mediator regulation of TRP channels | IL1B;ACCN5;ACCN3;ASIC3;ALOX12;MAPK12;CALM3;PRKACA;PRKCG |
Hrh1 has several biochemical functions, for example, G-protein coupled receptor activity, histamine binding, histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh1 itself. We selected most functions Hrh1 had, and list some proteins which have the same functions with Hrh1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | CCR10;TAAR7F;ADRB2A;DRD4-RS;F2RL1.1;CELSR2;TAAR14G;OLFR470;GRM8B |
| histamine binding | HRH1;HRH4;HRH3 |
| histamine receptor activity | HRH4;HRH1;HTR6;HRH2;HRH3 |
Hrh1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh1.
pyrilamine; IL6
Gene Family
Research Area
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