Hrh1

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Hrh1

Official Full Name histamine receptor H1
Background Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms HRH1; histamine receptor H1; histamine H1 receptor; H1R; HisH1; Histamine receptor subclass H1; HH1R; OTTHUMP00000160133; OTTHUMP00000207582; OTTHUMP00000207583; OTTHUMP00000209395; histamine H(1) receptor; histamine receptor, subclass H1; H1-R
    • Species :
    • Bovine
    • Guinea pig
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HRH1-1046H Recombinant Human Histamine Receptor H 1 Sf9 Insect Cell N/A
    Human HRH1-2134H Recombinant Human HRH1 Protein (211-416 aa), His-tagged E.coli His
    Human HRH1-27712TH Recombinant Human HRH1 Flag/His
    Human HRH1-5033H Recombinant Human HRH1 Protein Wheat Germ N/A
    Human HRH1-5034H Recombinant Human HRH1 Protein, GST-tagged Wheat Germ GST
    Human HRH1-5392HCL Recombinant Human HRH1 293 Cell Lysate HEK293 N/A
    Human HRH1-786H Recombinant Human HRH1 Protein, Flag-His-tagged Insect Cell His/Flag
    Rat HRH1-2911R Recombinant Rat HRH1 Protein Mammalian Cell His
    Rat HRH1-787R Recombinant Rat RHRH1 Protein, His/FLAG-tagged Insect Cell His/Flag
    Bovine HRH1-782B Recombinant Bovine HRH1 Protein, His/FLAG-tagged Insect Cell His/Flag
    Zebrafish HRH1-3832Z Recombinant Zebrafish HRH1 Mammalian Cell His
    Guinea Pig Hrh1-1042G Recombinant Guinea Pig Histamine Receptor H 1 Sf9 Insect Cell N/A
    Guinea pig Hrh1-784G Recombinant guinea pig Hrh1 Protein, His/FLAG-tagged Insect Cell His/Flag
    Kit-0969 Progesterone Receptor Competitor Assay Kit, Green N/A
    Kit-1343 HRH1 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    Hrh1 involved in several pathways and played different roles in them. We selected most pathways Hrh1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway NOS2B; GRM5; GNA15.1; HTR5A; PRKACBA; PPP3CA; CAMK2A; CAMK2G1; PHKG1; P2RX4
    Neuroactive ligand-receptor interaction TACR3; P2RX3; GABRA1; PRLRA; IL12; PTH1R; OPRD1; LEPR; TAAR1; NTSR1
    Inflammatory mediator regulation of TRP channels ASIC3; TRPV4; MAP2K3; IL1RAP; ASIC1; CYP4A10; CYP2J6; ASIC4; MAPK11; IL1R1

    Hrh1 has several biochemical functions, for example, G-protein coupled receptor activity, histamine binding, histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh1 itself. We selected most functions Hrh1 had, and list some proteins which have the same functions with Hrh1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity TAS2R103; FZD3B; MRGPRG; CCR10; KISS1RB; OR5B2; OR2L5; OR52J3; GRM6A; NPY8AR
    histamine binding HRH1; HRH4; HRH3
    histamine receptor activity HRH3; HRH4; HRH2; HTR6; HRH1

    Hrh1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh1.

    pyrilamine; IL6

    Costanza, M; Di Dario, M; et al. Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY 277:186-188(2014).
    Pagotto, RM; Pereyra, EN; et al. Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. JOURNAL OF ENDOCRINOLOGY 221:15-28(2014).

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