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Hrh1

  • Official Full Name

    histamine receptor H1

  • Overview

    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    HRH1; histamine receptor H1; histamine H1 receptor; H1R; HisH1; Histamine receptor subclass H1; HH1R; OTTHUMP00000160133; OTTHUMP00000207582; OTTHUMP00000207583; OTTHUMP00000209395; histamine H(1) receptor; histamine receptor, subclass H1; H1-R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Bovine
  • Cavia porcellus (Guinea pig)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Guinea pig
  • Guinea Pig
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag|His
  • GST
  • His (Fc)
  • Avi
  • Flag
  • His|Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HRH1-5033H Recombinant Human HRH1 Protein Wheat Germ N/A
Human HRH1-27712TH Recombinant Human HRH1 Flag/His
Human HRH1-5034H Recombinant Human HRH1 Protein, GST-tagged Wheat Germ GST
Human HRH1-786H Recombinant Human HRH1 Protein, Flag-His-tagged Insect Cell His/Flag
Human HRH1-1046H Recombinant Human Histamine Receptor H 1 Sf9 Insect Cell N/A
Human HRH1-5392HCL Recombinant Human HRH1 293 Cell Lysate HEK293 N/A
Human HRH1-2134H Recombinant Human HRH1 Protein (211-416 aa), His-tagged E.coli His 211-416 aa
Human HRH1-3663HF Recombinant Full Length Human HRH1 Protein In Vitro Cell Free System 644 amino acids
Human HRH1-1121HFL Recombinant Human HRH1 protein, His&Flag-tagged HEK293 His&Flag 1-487 aa
Human HRH1-3664HF Recombinant Full Length Human HRH1 Protein, GST-tagged In Vitro Cell Free System GST 487 amino acids
Human HRH1-2565H Recombinant Human HRH1 Protein (Lys212-Gln416), C-His tagged E.coli C-His Lys212-Gln416
Rat HRH1-2911R Recombinant Rat HRH1 Protein Mammalian Cell His
Rat HRH1-787R Recombinant Rat RHRH1 Protein, His/FLAG-tagged Insect Cell His/Flag
Rat HRH1-2566R Recombinant Rat HRH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HRH1-2566R-B Recombinant Rat HRH1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL4849BF Recombinant Full Length Bovine Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-491)
Bovine HRH1-782B Recombinant Bovine HRH1 Protein, His/FLAG-tagged Insect Cell His/Flag
Cavia porcellus (Guinea pig) RFL34521CF Recombinant Full Length Guinea Pig Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-488)
Gorilla gorilla gorilla (Western lowland gorilla) RFL12384GF Recombinant Full Length Gorilla Gorilla Gorilla Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-487)
Guinea Pig Hrh1-1042G Recombinant Guinea Pig Histamine Receptor H 1 Sf9 Insect Cell N/A
Guinea pig Hrh1-784G Recombinant guinea pig Hrh1 Protein, His/FLAG-tagged Insect Cell His/Flag
Homo sapiens (Human) RFL33116HF Recombinant Full Length Human Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-487)
Mus musculus (Mouse) RFL4498MF Recombinant Full Length Mouse Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-488)
Pan troglodytes (Chimpanzee) RFL23053PF Recombinant Full Length Pan Troglodytes Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-487)
Pongo pygmaeus (Bornean orangutan) RFL7763PF Recombinant Full Length Pongo Pygmaeus Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-487)
Rattus norvegicus (Rat) RFL2649RF Recombinant Full Length Rat Histamine H1 Receptor(Hrh1) Protein, His-Tagged E.coli expression system His Full Length (1-486)
Zebrafish HRH1-3832Z Recombinant Zebrafish HRH1 Mammalian Cell His
Kit-0969 Progesterone Receptor Competitor Assay Kit, Green N/A
Kit-1343 HRH1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Hrh1 Related Articles
  • Hrh1 Related Gene Family

Hrh1 involved in several pathways and played different roles in them. We selected most pathways Hrh1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPPP3R1B;PTGER1C;DRD5;ADRa1A;ITPR1;EDNRB;NOS1;ERBB4;TNNC1B
Neuroactive ligand-receptor interactionTAAR1B;HTR2B;ADRB2A;CHRNA3;P2RY10;TSHR;TSPO;GABBR2;GABRG2
Inflammatory mediator regulation of TRP channelsASIC4;IL1R1;PRKCB;PRKCH;CALML5;CYP2C70;PLA2G4F;PTGER2;CYP2J2

Hrh1 has several biochemical functions, for example, G-protein coupled receptor activity, histamine binding, histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh1 itself. We selected most functions Hrh1 had, and list some proteins which have the same functions with Hrh1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityFzd4;TAAR4;LPHN1;OXGR1A.2;RPA1;GPR151;TAAR10C;TAAR6;OPN5
histamine bindingHRH3;HRH1;HRH4
histamine receptor activityHRH1;HTR6;HRH2;HRH4;HRH3

Hrh1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh1.

pyrilamine; IL6

Costanza, M; Di Dario, M; et al. Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY 277:186-188(2014).
Pagotto, RM; Pereyra, EN; et al. Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. JOURNAL OF ENDOCRINOLOGY 221:15-28(2014).
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