IL4I1
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Official Full Name
interleukin 4 induced 1
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Background
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
IL4I1; interleukin 4 induced 1; LAO; FIG1; LAAO; L-amino-acid oxidase; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL4I1 Related Articles
IL4I1 involved in several pathways and played different roles in them. We selected most pathways IL4I1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Cysteine and methionine metabolism, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4I1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ybaS;ALDH5A1;GAD1B;GPT2;GOT1;AGXTB;GLS2;GPT;GFPT1 |
| Cysteine and methionine metabolism | MAT2AB;AGXT2;MAT2A;AHCY;CBS;SRM;LDHBB;LDHBA;SMS |
| Valine, leucine and isoleucine degradation | AOX2P;DLDH;HADHB;OXCT1B;ALDH3A2;HIBCH;HIBADHB;PCCA;ALDH1B1 |
| Tyrosine metabolism | ALDH3A1;GSTZ1;GOT2A;ADH2-2;COMTB;GOT2B;PNMT;ALDH3B1;FAH |
| Phenylalanine metabolism | HPDB;AOC2;ALDH3B1;HPDA;HPD;GM4952;PAH;ALDH3B2;AOC3 |
| Tryptophan metabolism | ALDH7A1;AOC1;RNF25;TDO2A;GCDH;HADHAB;MAOA;ABP1;CAT |
| Phenylalanine, tyrosine and tryptophan biosynthesis | PAH;GOT1;TAT;IL4I1;GOT2A;GOT2B;GOT2 |
| Metabolic pathways | FUT9A;DHDPSL;PIGS;NAGLU;IL4I1;A4GALT;ALLC;ST6GALNAC6;UGT1A6B |
IL4I1 has several biochemical functions, for example, L-amino-acid oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4I1 itself. We selected most functions IL4I1 had, and list some proteins which have the same functions with IL4I1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-amino-acid oxidase activity |
IL4I1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4I1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4I1.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.
This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.
IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.
The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.
IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.
The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.
Customer Reviews (3)
Write a reviewThe protein was isolated by polyacrylamide gel electrophoresis, and the purity and protein composition of IL4I1 were determined according to molecular weight. -
Molecular docking: The binding pattern of IL4I1 and its ligand is predicted by computational methods to obtain information about its structure and stability. -
The thermal stability of IL4I1 was evaluated by heating the protein and observing its changes at different temperatures. -
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