Active Recombinant Human Interleukin 4 Induced 1, His-tagged IL4I1-654H

Active Recombinant Human Interleukin 4 Induced 1, His-tagged


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Cat.No. : IL4I1-654H Optional Service: Optional requirements on this protein
Product Overview : RecombinantHuman IL4I1 protein was expressed in Chinese HamsterOvary cell line. Gln22-His567, with a C-terminal 6-Histag.
Description : IL4I1 isencoded by a B-cell IL-4-inducible gene, FIG1, and is highly expressed inprimary metastinal B-cell lymphomas. It belongs to the flavin monoamineoxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1has L-amino acid oxidase activity with preference toward aromatic aminoacids. Studies have shown that hIL-4I1 inhibited the proliferation ofCD3-stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) Tcells. Its inhibitory effect was dependent on enzymatic activity and H2O2 production.Its restricted expression to lymphoid tissues indicates that it may play animportant function in the immune system.
Source : Chinese HamsterOvary cell line, CHO-derived.
Form : Supplied as a 0.2 umfiltered solution in Tris, NaCl and Glycerol.
N-terminalSequence : Gln22 predicted.
MolecularWeight : 61 kDa
Activity : Measuredby its ability to oxidize phenylalanine in a horseradish peroxidase coupled assay.The specific activity is > 150 pmol/min/μg, as measured under the describedconditions.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 70-75kDa, reducing conditions.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.
Gene Name : IL4I1 interleukin 4 induced 1[ Homo sapiens ]
Official Symbol : IL4I1
Synonyms : IL4I1; interleukin 4induced 1; LAO;FIG1; LAAO; L-amino-acidoxidase; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1; EC1.4.3.2
Gene ID : 259307
mRNA Refseq : NM_172374
Protein Refseq : NP_758962
MIM : 609742
UniProt ID : Q96RQ9
Chromosome Location : 19q13.3-q13.4
Pathway : Alanine, aspartate and glutamate metabolism;Cysteine and methionine metabolism; Metabolic pathways; Phenylalaninemetabolism; Phenylalanine; Tryptophan metabolism; Tyrosine metabolism; Valine,leucine and isoleucine degradation
Function : L-amino-acid oxidaseactivity; oxidoreductase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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