Active Recombinant Human Interleukin 4 Induced 1, His-tagged

• Cat.No.: IL4I1-654H
• Product Overview: RecombinantHuman IL4I1 protein was expressed in Chinese HamsterOvary cell line. Gln22-His567, with a C-terminal 6-Histag.

Specification

• Species: Human
• Source: CHO
• Tag: His
• Protein Length: 22-567 a.a.
• Description: IL4I1 isencoded by a B-cell IL-4-inducible gene, FIG1, and is highly expressed inprimary metastinal B-cell lymphomas. It belongs to the flavin monoamineoxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1has L-amino acid oxidase activity with preference toward aromatic aminoacids. Studies have shown that hIL-4I1 inhibited the proliferation ofCD3-stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) Tcells. Its inhibitory effect was dependent on enzymatic activity and H2O2 production.Its restricted expression to lymphoid tissues indicates that it may play animportant function in the immune system.
• Form: Supplied as a 0.2 umfiltered solution in Tris, NaCl and Glycerol.
• N-terminalSequence: Gln22 predicted.
• MolecularWeight: 61 kDa
• Activity: Measuredby its ability to oxidize phenylalanine in a horseradish peroxidase coupled assay.The specific activity is > 150 pmol/min/μg, as measured under the describedconditions.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 70-75kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.

Gene Information

• Gene Name: IL4I1 interleukin 4 induced 1[ Homo sapiens ]
• Official Symbol: IL4I1
• Synonyms: IL4I1; interleukin 4induced 1; LAO;FIG1; LAAO; L-amino-acidoxidase; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1; EC1.4.3.2
• Gene ID: 259307
• mRNA Refseq: NM_172374
• Protein Refseq: NP_758962
• MIM: 609742
• UniProt ID: Q96RQ9
• Chromosome Location: 19q13.3-q13.4
• Pathway: Alanine, aspartate and glutamate metabolism;Cysteine and methionine metabolism; Metabolic pathways; Phenylalaninemetabolism; Phenylalanine; Tryptophan metabolism; Tyrosine metabolism; Valine,leucine and isoleucine degradation
• Function: L-amino-acid oxidaseactivity; oxidoreductase activity