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Recombinant Full Length Human IL4I1 Protein, C-Flag-tagged

Cat.No. : IL4I1-1563HFL
Product Overview : Recombinant Full Length Human IL4I1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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  • Gene Information
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Description : This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 65.1 kDa
AA Sequence : MPNDDFCPGLTIKAMGAERAPQRQP CTLHLLVLVPILLSLVASQDWKAER SQDPFEKCMQDPDYEQLLKV VTWGLNRTLKPQRVIVVGAGVAGLV AAKVLSDAGHKVTILEADNRIGGRI FTYRDQNMGWIGELGAMRMP SSHRILHKLCQGLGLNLTKFTQYDK NTWTEVHEVKLRNYVVEKVPEKLGY ALRPQEKGHSPEDIYQMALN QALKDLKALGCRKAMKKFERHTLLE YLLGEGNLSRPAVQLLGDVMSEDGF FYLSFAEALRAHSCLSDRLQ YSRIVGGWDLLPRALLSSLSGLVLL NAPVVAMTQGPHDVHVQIETSPPAR NLKVLKADVVLLTASGPAVK RITFSPPLPRHMQEALRRLHYVPAT KVFLSFRRPFWREEHIEGGHSNTDR PSRMIFYPPPREGALLLASY TWSDAAAAFAGLSREEALRLALDDV AALHGPVVRQLWDGTGVVKRWAEDQ HSQGGFVVQPPALWQTEKDD WTVPYGRIYFAGEHTAYPHGWVETA VKSALRAAIKINSRKGPASDTASPE GHASDMEGQGHVHGVASSPS
HDLAKEEGSHPPVQGQLSLQNTTHT RTSHTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome
Protein Pathways : Alanine, aspartate and glutamate metabolism, Cysteine and methionine metabolism, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism, Valine, leucine and isoleucine degradation
Gene Name : IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]
Official Symbol : IL4I1
Synonyms : LAO; FIG1; LAAO; hIL4I1
Gene ID : 259307
mRNA Refseq : NM_172374.3
Protein Refseq : NP_758962.1
MIM : 609742
UniProt ID : Q96RQ9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to determine the dose of IL4I1 in clinical treatment? 12/12/2022

The dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.

What are the biological functions of IL4I1? 02/04/2022

This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.

What problems should be paid attention to when IL4I1 is used in preclinical animal test studies? 01/09/2022

IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.

Is there any side effect of IL4I1? 01/29/2021

The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.

What is the mechanism of IL4I1 in tumor therapy? 12/30/2020

IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.

How the purification technologies of IL4I1? 06/04/2019

The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.

Customer Reviews (3)

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Reviews
07/19/2022

    The consistency and reliability of this protein are good.

    02/13/2021

      Under the influence of temperature, humidity and light, this protein is stable and durable.

      10/24/2020

        This protein is immunogenic and allergenic, which is even more important for proteins used in drug development.

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