Recombinant Full Length Human IL4I1 Protein, C-Flag-tagged
Cat.No. : | IL4I1-1563HFL |
Product Overview : | Recombinant Full Length Human IL4I1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 65.1 kDa |
AA Sequence : | MPNDDFCPGLTIKAMGAERAPQRQP CTLHLLVLVPILLSLVASQDWKAER SQDPFEKCMQDPDYEQLLKV VTWGLNRTLKPQRVIVVGAGVAGLV AAKVLSDAGHKVTILEADNRIGGRI FTYRDQNMGWIGELGAMRMP SSHRILHKLCQGLGLNLTKFTQYDK NTWTEVHEVKLRNYVVEKVPEKLGY ALRPQEKGHSPEDIYQMALN QALKDLKALGCRKAMKKFERHTLLE YLLGEGNLSRPAVQLLGDVMSEDGF FYLSFAEALRAHSCLSDRLQ YSRIVGGWDLLPRALLSSLSGLVLL NAPVVAMTQGPHDVHVQIETSPPAR NLKVLKADVVLLTASGPAVK RITFSPPLPRHMQEALRRLHYVPAT KVFLSFRRPFWREEHIEGGHSNTDR PSRMIFYPPPREGALLLASY TWSDAAAAFAGLSREEALRLALDDV AALHGPVVRQLWDGTGVVKRWAEDQ HSQGGFVVQPPALWQTEKDD WTVPYGRIYFAGEHTAYPHGWVETA VKSALRAAIKINSRKGPASDTASPE GHASDMEGQGHVHGVASSPS HDLAKEEGSHPPVQGQLSLQNTTHT RTSHTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Alanine, aspartate and glutamate metabolism, Cysteine and methionine metabolism, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism, Valine, leucine and isoleucine degradation |
Gene Name : | IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ] |
Official Symbol : | IL4I1 |
Synonyms : | LAO; FIG1; LAAO; hIL4I1 |
Gene ID : | 259307 |
mRNA Refseq : | NM_172374.3 |
Protein Refseq : | NP_758962.1 |
MIM : | 609742 |
UniProt ID : | Q96RQ9 |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.
This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.
IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.
The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.
IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.
The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.
Customer Reviews (3)
Write a reviewThe consistency and reliability of this protein are good.
Under the influence of temperature, humidity and light, this protein is stable and durable.
This protein is immunogenic and allergenic, which is even more important for proteins used in drug development.
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