Recombinant Human IL4I1 Protein, His-tagged
| Cat.No. : | IL4I1-2320H |
| Product Overview : | Recombinant Human IL4I1 Protein (Met1-Glu245) with a N-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. |
| Source : | E. coli |
| Species : | Human |
| Tag : | N-His |
| Form : | Freeze-dried powder |
| Molecular Mass : | Predicted Molecular Mass: 32.1 kDa Accurate Molecular Mass: 32 kDa |
| Protein length : | Met1-Glu245 |
| Endotoxin : | <1.0 EU per 1µg (determined by the LAL method). |
| Purity : | > 95% |
| Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
| Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
| Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
| Reconstitution : | Reconstitute in ddH2O to a concentration of 0.1-0.8 mg/mL. Do not vortex. |
| Gene Name : | IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ] |
| Official Symbol : | IL4I1 |
| Synonyms : | IL4I1; interleukin 4 induced 1; L-amino-acid oxidase; FIG1; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1; LAO; LAAO; |
| Gene ID : | 259307 |
| mRNA Refseq : | NM_001258017 |
| Protein Refseq : | NP_001244946 |
| MIM : | 609742 |
| UniProt ID : | Q96RQ9 |
Products Types
| ◆ Recombinant Protein | ||
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| IL4I1-1178H | Recombinant Human IL4I1 Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL4I1-8173M | Recombinant Mouse IL4I1 Protein | +Inquiry |
| IL4I1-01H | Recombinant Human IL4I1 Protein, His-Tagged | +Inquiry |
| Il4i1-639M | Active Recombinant Mouse Il4i1 protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| IL4I1-5225HCL | Recombinant Human IL4I1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (6)
Ask a questionThe dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.
This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.
IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.
The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.
IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.
The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.
Customer Reviews (3)
Write a reviewThe protein was isolated by polyacrylamide gel electrophoresis, and the purity and protein composition of IL4I1 were determined according to molecular weight. -
Molecular docking: The binding pattern of IL4I1 and its ligand is predicted by computational methods to obtain information about its structure and stability. -
The thermal stability of IL4I1 was evaluated by heating the protein and observing its changes at different temperatures. -
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