Recombinant Human IL4I1 Protein, His-tagged

Cat.No. : IL4I1-2320H
Product Overview : Recombinant Human IL4I1 Protein (Met1-Glu245) with a N-His tag was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene.
Source : E. coli
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 32.1 kDa
Accurate Molecular Mass: 32 kDa
Protein length : Met1-Glu245
Endotoxin : <1.0 EU per 1µg (determined by the LAL method).
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in ddH2O to a concentration of 0.1-0.8 mg/mL. Do not vortex.
Gene Name : IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]
Official Symbol : IL4I1
Synonyms : IL4I1; interleukin 4 induced 1; L-amino-acid oxidase; FIG1; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1; LAO; LAAO;
Gene ID : 259307
mRNA Refseq : NM_001258017
Protein Refseq : NP_001244946
MIM : 609742
UniProt ID : Q96RQ9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (6)

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How to determine the dose of IL4I1 in clinical treatment? 12/12/2022

The dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.

What are the biological functions of IL4I1? 02/04/2022

This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.

What problems should be paid attention to when IL4I1 is used in preclinical animal test studies? 01/09/2022

IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.

Is there any side effect of IL4I1? 01/29/2021

The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.

What is the mechanism of IL4I1 in tumor therapy? 12/30/2020

IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.

How the purification technologies of IL4I1? 06/04/2019

The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.

Customer Reviews (3)

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    The protein was isolated by polyacrylamide gel electrophoresis, and the purity and protein composition of IL4I1 were determined according to molecular weight. -


      Molecular docking: The binding pattern of IL4I1 and its ligand is predicted by computational methods to obtain information about its structure and stability. -


        The thermal stability of IL4I1 was evaluated by heating the protein and observing its changes at different temperatures. -

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