Il4ra
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Official Full Name
interleukin 4 receptor, alpha
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Background
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind;interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to;promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the;membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by;T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as;allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to;human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. -
Synonyms
interleukin 5 (colony-stimulating factor, eosinophil); IL5; IL-5; interleukin 5; TRF; T-cell replacing factor; interleukin-5; eosinophil differentiation factor;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il4ra Related Gene Family
Il4ra involved in several pathways and played different roles in them. We selected most pathways Il4ra participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il4ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | GH1;AMH;CSF2RB;IL25;CXCL5;FASLG;Ccl27a;TGFB3;CCL25 |
| PIK-Akt signaling pathway | SPP1;LAMA3;VEGFC;PPP2CB;KITLG;RXRA;IFNA16;RPS6KB2;FASLG |
| Jak-STAT signaling pathway | IL-15RA;SOCS4;IFNG1-2;SOCS9;GM13305;IL12B;IL5;IFNA14;IL13RA1 |
| Hematopoietic cell lineage | CD9;CD1d1;ITGA2B;EPOR;CD59A;CD1C;CD36;CR1;GM13305 |
| Inflammatory bowel disease (IBD) | STAT1;TGFB1;TLR5;IL12RB2;SMAD3;IL18RAP;IL1B;Il4ra;STAT4 |
Il4ra has several biochemical functions, for example, cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il4ra itself. We selected most functions Il4ra had, and list some proteins which have the same functions with Il4ra. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | IL13RA2;Il6ra;CRFB15;CRFB4;IL21R.2;IL17RB;CSF3R;IL20RB;LEPR |
| protein binding | PRDM5;HPS4;HSPA12B;FUBP3;OSBPL7;FANCB;TRIM38;PRCP;SNX9 |
Il4ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il4ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il4ra.
- Q&As
- Reviews
Q&As (6)
Ask a questionIl4ra is mainly used for treatment, and it has not been reported that it can be used to prevent disease.
The safety of Il4ra has not been adequately studied in pregnant or lactating women and should be used with caution.
Mechanism of action of Il4ra is to regulate the immune response by inhibiting the Il4 signaling pathway.
The production process and quality control of Il4ra require strict compliance with relevant regulations and standards, including Good Manufacturing practice (GMP), to ensure their safety and effectiveness.
The length of treatment for Il4ra depends on the nature of the disease and the patient's response to treatment, and generally lasts from several weeks to several months.
There are a number of clinical trials underway for recombinant Il4ra, which have shown some efficacy in the treatment of asthma, autoimmune diseases, etc.
Customer Reviews (3)
Write a reviewBinding affinity between IL4RA and IL-4RA was evaluated by ion exchange chromatography and affinity chromatography, and the strength of its binding ability was determined. -
Stability of IL4RA protein under different conditions, including cryopreservation, long-term storage and transportation, was evaluated by thermal stability test and long-term storage stability test. -
The functional properties of IL4RA can be evaluated through in vitro and in vivo experiments, such as cell signaling pathway experiments, cell proliferation experiments, etc. -
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