Il4ra Protein


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Official Full Name interleukin 4 receptor, alpha
Background This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind;interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to;promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the;membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by;T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as;allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to;human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Synonyms interleukin 5 (colony-stimulating factor, eosinophil); IL5; IL-5; interleukin 5; TRF; T-cell replacing factor; interleukin-5; eosinophil differentiation factor
    • Type:
    • Species :
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il4ra-5662M Active Recombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged Mammalian cells Fc Inquiry
    Mouse Il4ra-1757M Recombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged Mammalian cells Fc Inquiry
    Mouse Il4ra-1758M Recombinant Mouse Il4ra protein, His-tagged HEK293 His Inquiry
    Mouse Il4ra-2130M Recombinant Mouse Il4ra protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse IL4RA-8174M Recombinant Mouse IL4RA Protein Mammalian Cell His Inquiry
    Rat IL4RA-3048R Recombinant Rat IL4RA Protein Mammalian Cell His Inquiry
    Rat Il4ra-7458R Recombinant Rat Il4ra, His tagged Human Cell His Inquiry
    Mouse IL4RA-351M Recombinant Mouse IL4RA protein, Fc-tagged HEK293 Fc Inquiry

    Il4ra involved in several pathways and played different roles in them. We selected most pathways Il4ra participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il4ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL12RB2; IL12RB1; IL18; CCR10; CCL25B; IL2RA; IFN-a; VEGFB; CCR1L1; IRX1
    PIK-Akt signaling pathway FGFR2; INS2; FGF14; IL4; Il2; PKN3; FGF6; PIK3CG; TNN; TNXB
    Jak-STAT signaling pathway STAT3; IL11; IL23R; CSH; PTPN2B; IL12RB1; IFNA6; IFNA7; IL12BA; SOCS9
    Hematopoietic cell lineage CR2; CD1C; ITGA6; HLA-DRB5; GM2002; GP9; Itgam&Itgb2; GP1BA; CD8B; CD14
    Inflammatory bowel disease (IBD) STAT4; TLR5; Il2; IL4R; IL12A; IL1A; IL2RG; Il4ra; IL23R; IL18R1

    Il4ra has several biochemical functions, for example, cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il4ra itself. We selected most functions Il4ra had, and list some proteins which have the same functions with Il4ra. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity IL15RA; LIFRA; CSF3R; IL12B; IL21R.2; CRFB6; LEPR; IL28RA; CRFB12; CRFB15
    protein binding C15orf23; PIK3R3; GLS2; GRK6; DDX19B; DIS3; APEX1; pab1; ATF3; PTPRE

    Il4ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il4ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il4ra.

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