Active Recombinant Mouse Il4ra Homodimer Protein, His tagged

• Cat.No.: Il4ra-45M
• Product Overview: IL-4Rα dimer protein contains an IL-4Rα extracellular domain (UniProt# P16382) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: His
• Protein Length: 26-233 aa
• Description: Interleukin 4 receptor alpha (IL-4Rα) is a Type I transmembrane and a Type 1 cytokine receptor. IL-4Rα is also known as cluster of differentiation 124 (CD124). IL-4Rα is a key component in interleukin 4 (IL-4) and IL-13 cytokine signaling involved in immune regulation, particularly in Th2 immune responses, allergy, and asthma. IL-4Rα contains an extracellular domain with an overall L shape organized in two covalently linked domains: an h-type immunoglobulin fold (D1) and a standard fibronectin type III (FN III)–like topology (D2). IL-4Rα can bind IL-4 and IL-13 and allergic inflammation is largely driven by IL-4 and IL-13 signaling through IL-4Rα, making IL-4Rα a promising therapeutic target for allergic diseases. While structurally and functionally similar to human IL-4Rα homodimer, mouse IL-4Rα homodimer is a species-specific tool essential for preclinical studies, basic research, and translational research.
• Molecular Mass: 65 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for IL-4Rα-specific antibody binding assays. Suggested Applications: SPR & BLI for IL-4Rα-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: Il4ra interleukin 4 receptor, alpha [ Mus musculus (house mouse) ]
• Official Symbol: Il4ra
• Synonyms: IL4RA; interleukin 4 receptor, alpha; interleukin-4 receptor subunit alpha; IL-4RA; IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; Il4r; CD124; MGC118473
• Gene ID: 16190
• mRNA Refseq: NM_001008700
• Protein Refseq: NP_001008700
• UniProt ID: P16382