itga2
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  • Official Full Name
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
  • Background
  • This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia; platelet glycoprotein GPIa; CD49 antigen-like fam
Cat.#:ITGA2-1840HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ITGA2 Protein (188-365 aa), His-tagged
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Cat.#:ITGA2-5000HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA2 Protein, GST-tagged
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Cat.#:ITGA2&ITGB1-738HTag:N/A
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGA2&ITGB1
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Cat.#:ITGA2-5836HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA2 protein, His & S-tagged
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Cat.#:Itga2-5837MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itga2 protein, His & GST-tagged
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Cat.#:ITGA2-8347MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGA2 Protein
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Cat.#:ITGA2-2313RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ITGA2 Protein, His-tagged
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Cat.#:ITGA2-5835CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ITGA2 protein, His-tagged
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Cat.#:ITGA2-5135HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ITGA2 293 Cell Lysate
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Involved Pathway

ITGA2 involved in several pathways and played different roles in them. We selected most pathways ITGA2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
CTSL1B; ITGB1A; RAB5B; TFRC; TUBA1L; ITGB1; ACTB2; ITGA2; ATP6V0B; BLB2
PIK-Akt signaling pathway
ITGB6; Il6ra; LPAR3; ITGA3; GNB3; PPP2R2C; CCND1; NOS3; FGF1; HSP90AA1
Focal adhesion
PPP1CAB; COL24A1; ITGB5; PARVA; LAMA1; VEGFAA; PPP1CB; HGF; PDGFRA; ZYX
ECM-receptor interaction
LAMA5; VTNA; COL6A4; COL4A2; GP1BB; GP5; SDC4; CHAD; THBS3; ITGA2B
Platelet activation
GP1BB; PIK3CD; VASP; GNAI1; PPP1CB; PRKCI; LYN; ARHGAP35; GUCY1B3; PIK3R1
Hematopoietic cell lineage
IL4; CD38; CR1; EPO; CD4; ITGA1; TFRC; KITLG; Cd24a; CSF1R
Regulation of actin cytoskeleton
EZR; ACTN2B; MYL2B; PPP1R12B; ITGA9; RHOAA; TMSB; CHRM5B; ACTN4; SSH3
Pathways in cancer
MSH2; CTNNA3; TRAF1; Kitl; FGFR2; IGF1R; WNT11; NTRK1; WNT9B; GSTP1
Proteoglycans in cancer
MRAS; CCND1; CBLC; CAMK2G; PIK3R3; STAT3; MAPK3; SMO; HIF1A; ROCK2
Small cell lung cancer
BIRC7; ITGB1; RELA; TRP53; LAMB1; PTGS2; APAF1; FN1; ITGA2B; CCND1
Hypertrophic cardiomyopathy (HCM)
ITGA1; IL6; ITGB7; Itga10&Itgb1; PRKAA2; PRKAG3; ITGA3; ITGB1; CACNA2D1; ITGA4
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GJA1; CACNB3; ACTN4; CACNB2; JUP; CACNA2D4; PKP2; ITGA2B; CTNNA3; CACNA2D3
Dilated cardiomyopathy
MYH7; PRKACG; ITGA10; ITGA7; PLN; ATP2A2; CACNG3; TGFB2; CACNA2D2; TNF

Protein Function

ITGA2 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2 itself. We selected most functions ITGA2 had, and list some proteins which have the same functions with ITGA2. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein FN1; SMAD7; LRRC15; CHADL; PDGFB; ANTXR1; MMP9; SMAD3; VWF; C1QTNF1
Function collagen binding involved in cell-matrix adhesion
Related Protein ITGA10; Itga10&Itgb1; ITGA2; ITGA1; ITGB1
Function collagen receptor activity
Related Protein ITGA2
Function metal ion binding
Related Protein CYP2P7; ISL1L; ITGA5; BCL11BA; ZFP30; MCM10; NOS2B; OASL2; JAZF1; ATP1A1A.3
Function protein binding
Related Protein LIPT2; NGB; GTF2E1; PLK1S1; SEC14L4; CHCHD2; MKRN3; KRTAP2-3; AP1G1; PRDX3
Function virus receptor activity
Related Protein DAG1; ITGA2; CD46; NPC1; CD80; ICAM1; ITGAV; SCARB1; GYPA; F11R

Interacting Protein

ITGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2.
SHARPIN; Rab21; ITGB1; FABP3; COL1A2; PDIA3; Rab21

ITGA2 Related Articles

Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).