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Official Full Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Background This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Synonyms ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia; platelet glycoprotein GPIa; CD49 antigen-like fam
    • Species :
    • Cattle
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA2&ITGB1-738H Recombinant Human ITGA2&ITGB1 CHO N/A
    Human ITGA2-1840H Recombinant Human ITGA2 Protein (188-365 aa), His-tagged Yeast His
    Human ITGA2-5000H Recombinant Human ITGA2 Protein, GST-tagged Wheat Germ GST
    Human ITGA2-5135HCL Recombinant Human ITGA2 293 Cell Lysate HEK293 N/A
    Human ITGA2-5836H Recombinant Human ITGA2 protein, His & S-tagged E.coli His/S
    Mouse Itga2-5837M Recombinant Mouse Itga2 protein, His & GST-tagged E.coli His/GST
    Mouse ITGA2-8347M Recombinant Mouse ITGA2 Protein Mammalian Cell His
    Rhesus Macaque ITGA2-2313R Recombinant Rhesus monkey ITGA2 Protein, His-tagged Mammalian Cell His
    Cattle ITGA2-5835C Recombinant Cattle ITGA2 protein, His-tagged E.coli His

    ITGA2 involved in several pathways and played different roles in them. We selected most pathways ITGA2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway PDGFRA; ITGAV; CREB3L2; MAP2K2; COL24A1; G6PC2; CREB3L3; IFNB1; ITGA7; Pdgfa&Pdgfb
    Focal adhesion PAK6; TNR; PDGFRB; RAP1AB; TESK2; MYL9A; SOS1; VWF; PAK7; SRC
    ECM-receptor interaction TNN; ITGA1; ITGA8; COL2A1A; GP9; ITGA2; COL6A4; LAMA3; ITGA3B; LAMB2
    Platelet activation PTGIR; FCGR2A; MYLK4; ITGB1; TLN1; MYLK2; PLCG2; ITPR1; P2RY1; PRKACG
    Hematopoietic cell lineage IL4; IL6; ITGA2B; IL5RA; IL7; CD59A; Il6ra; CD59; CD1E, B2M; CD14
    Regulation of actin cytoskeleton PAK2B; RAC2; CDC42; VAV3B; PFN1; VCL; Fgf15; ITGA2B; FGF10; MYL2B
    Pathways in cancer ARNT; RXRB; MAP2K1; PTCH2; GNGT1; LAMA4; CBL; VEGFA; GNB4; FH1
    Proteoglycans in cancer ROCK2; PXN; WNT2B; FGFR1; SDC2; Fasl; RPS6KB1; ESR1; Fzd4; BRAF
    Small cell lung cancer RB1; LAMA1; TRAF5; LAMB1; TRAF3; MAX; TRAF6; BIRC7; TRP53; LAMC1
    Hypertrophic cardiomyopathy (HCM) CACNG8; SGCA; ITGB3; ITGA3; ITGA6; EMD; CACNB3; DAG1; IL6; ITGB5
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) LMNA; SLC8A1; ITGA3; ACTN1; ITGA2; ITGA4; CTNNA3; DMD; CACNB3; CDH2
    Dilated cardiomyopathy ACTB; ATP2A2; CACNB1; SGCG; TPM4; ITGB7; TGFB3; ITGA2; CACNG6; MYL3

    ITGA2 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2 itself. We selected most functions ITGA2 had, and list some proteins which have the same functions with ITGA2. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding PCOLCE; VWF; PCOLCE2; SPARC; FN1; ADAM9; MMP9; CTSL1; SERPINH1B; CTSK
    collagen binding involved in cell-matrix adhesion ITGA10; ITGA1; ITGA2; ITGB1; Itga10&Itgb1
    collagen receptor activity ITGA2
    metal ion binding ZNF800B; LPO; TRIM59; C1GALT1B; EPX; TRIM55A; ZNF239; ZFP830; TAX1BP1; ZFP428
    virus receptor activity ICAM1; ACE2; SLC20A2; RPSA; DAG1; ITGB5; CLEC4G; ITGA5; CLEC4M; SELPLG

    ITGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2.

    SHARPIN; Rab21; ITGB1; FABP3; COL1A2; PDIA3; Rab21

    Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
    Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).

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