ITGA2

  • Official Full Name

    integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

  • Overview

    This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
  • Synonyms

    ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia; platelet glycoprotein GPIa; CD49 antigen-like fam;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Monkey
  • Mouse
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Strep
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA2&ITGB1-738H Active Recombinant Human ITGA2&ITGB1 CHO N/A
Human ITGA2-5836H Recombinant Human ITGA2 protein, His & S-tagged E.coli His/S Pro170~Ile361 (Accession # P17301)
Human ITGA2-5135HCL Recombinant Human ITGA2 293 Cell Lysate HEK293 N/A
Human ITGA2-2671H Recombinant Human ITGA2 protein(711-790 aa), C-His-tagged E.coli C-His 711-790 aa
Human ITGA2-5000H Recombinant Human ITGA2 Protein, GST-tagged Wheat Germ GST
Human ITGA2-3123H Recombinant Human ITGA2 protein, His-SUMO-tagged E.coli His-SUMO 188-365aa
Human ITGA2-1840H Recombinant Human ITGA2 Protein (188-365 aa), His-tagged Yeast His 188-365 aa
Human ITGA2-5006H Recombinant Human ITGA2 protein, His-tagged E.coli N-His 188-365aa
Human ITGA2-4317H Recombinant Human ITGA2 Protein (Met1-Thr1132), C-His tagged Mammalian cells C-His Met1-Thr1132
Mouse ITGA2-8347M Recombinant Mouse ITGA2 Protein Mammalian Cell His
Mouse Itga2-5837M Recombinant Mouse Itga2 protein, His & GST-tagged E.coli His/GST Gln212~Asn370 (Accession# Q62469)
Mouse ITGA2-4634M Recombinant Mouse ITGA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ITGA2-4634M-B Recombinant Mouse ITGA2 Protein Pre-coupled Magnetic Beads HEK293
Monkey ITGA2-5838M Recombinant Monkey ITGA2 (Met1-Pro908) and ITGB3 (Met1-Pro717) Protein, C-His and C-Strep tagged Mammalian cells C-His and Strep ITGA2: Met1-Pro908<br />ITGB3: Met1-Pro717
Cattle ITGA2-5835C Recombinant Cattle ITGA2 protein, His-tagged E.coli His Leu106~Gly302
Rhesus Macaque ITGA2-2313R Recombinant Rhesus monkey ITGA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ITGA2-2134R-B Recombinant Rhesus Macaque ITGA2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ITGA2-2134R Recombinant Rhesus Macaque ITGA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ITGA2 involved in several pathways and played different roles in them. We selected most pathways ITGA2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBA1B;HLA-B;CANX;CLEC7A;TUBB2A;HLA-DOB;ATP6V1G1;RAB5B;CLEC4M
PIK-Akt signaling pathwayFOXO3;EIF4E1B;PIK3R5;GH1;PCK1;Pdgfa&amp;Pdgfb;IRS1;YWHAG;CRTC2
Focal adhesionPDGFB;AKT2;THBS4B;PIK3CA;VEGFAA;IGF1RB;DIAP1;ELK1;RHOB
ECM-receptor interactionITGA10;CD47;COL4A6;COL4A5;LAMA4;LAMC3;THBS2;THBS4A;LAMA3
Platelet activationPIK3CG;PIK3CD;PRKCZ;P2RX1;SNAP23;F2R;PLA2G4C;PLA2G4A;F2RL3
Hematopoietic cell lineageItga10&amp;Itgb1;HLA-DRA;IL1R1;CD1E;CSF3R;IL1R2;CD14;ANPEP;CD44
Regulation of actin cytoskeletonFN1;INS1;GSNA;MAPK1;ACTB1;PPP1CBL;MYH9;FGF18;FGF13B
Pathways in cancerCCDC6;NCOA4;COL4A1;CSF1R;FN1;MSH2;FGF11;ITGA3;BIRC7
Proteoglycans in cancerPLAUR;MET;PDPK1;WNT7A;ESR1;RPS6;SOS1;PIK3CB;PRKCA
Small cell lung cancerXIAP;TRAF6;RB1;APAF1;ITGA2B;FN1;FHIT;NFKB1;TRAF1
Hypertrophic cardiomyopathy (HCM)ACE;TPM4;ACTC1;SGCB;CACNB4;MYL2;ITGA9;PRKAB1;DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)SGCA;CACNG2;ITGB8;DMD;PKP2;ITGB3;SGCD;CACNA2D2;GJA1
Dilated cardiomyopathyMYBPC3;TNNI3;ITGB6;CACNG2;MYL3;EMD;MYH7;ITGA2;Itga10&amp;Itgb1

ITGA2 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2 itself. We selected most functions ITGA2 had, and list some proteins which have the same functions with ITGA2. You can find most of the proteins on our site.

Function Related Protein
collagen bindingTGFBI;RELL2;SERPINH1B;SERPINH1A;PCOLCE;LRRC15;SPARC;SMAD4;GP6
collagen binding involved in cell-matrix adhesionITGA10;ITGA1;ITGB1;Itga10&amp;Itgb1;ITGA2
collagen receptor activity
metal ion bindingKLF2B;SMYD1B;FBXO30A;C6AST4;RUNX1T1;OMA1;KDM2BA;ZDHHC18A;DNAJA3B
protein bindingTRPC5;TREX1;C10orf46;OLIG1;GOLGA2;KCNK16;NCKAP1;NECAB2;PDP1
virus receptor activityCD209A;IDE;CD209;HSPA1A;F11R;SIVA1;NCAM1;CD86;PVRL1

ITGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2.

SHARPIN; Rab21; ITGB1; FABP3; COL1A2; PDIA3; Rab21

Research Area

Related articles

Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
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