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Official Full Name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Background Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Synonyms 95 subunit beta; Beta 2 (antigen CD18 (p95); CD 18; CD18; CD18 antigen; Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor); Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150; Complement component 3 receptor 3 and 4 subunit; Complement receptor C3 beta subunit; Complement receptor C3 subunit beta; Integrin beta 2; Integrin beta chain beta 2; Integrin beta-2; Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2_HUMAN; ITGB 2; ITGB2; LAD; LCAMB; Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; LFA 1; LFA1; Lymphocyte function associated antigen 1; MAC 1; MAC1; Macrophage antigen 1 (mac1) beta subunit; MF17; MFI7; LFA-1; MAC-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Rat
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Avi
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGAL & ITGB2-7130H Recombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAM&ITGB2-692H Recombinant Human ITGAM&ITGB2 CHO N/A
    Human ITGAX & ITGB2-1875HCL Recombinant Human ITGAX & ITGB2 cell lysate Human Cell N/A
    Human ITGB2-181H Recombinant Human ITGB2 protein, T7/His-tagged E.coli T7/His
    Human ITGB2-1922H Recombinant Human ITGB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ITGB2-26324TH Recombinant Human ITGB2 Wheat Germ N/A
    Human ITGB2-26325TH Recombinant Human ITGB2 Wheat Germ N/A
    Human ITGB2-4978H Recombinant Human ITGB2 Protein, GST-tagged Wheat Germ GST
    Human ITGB2-5125HCL Recombinant Human ITGB2 293 Cell Lysate HEK293 N/A
    Human ITGB2-71H Recombinant Human ITGB2 protein, His-tagged Insect Cell His
    Mouse DMABT-H24736 Rat Anti-ITGB2 Monoclonal Antibody Rat N/A
    Mouse Itgam&Itgb2-605M Recombinant Mouse Itgam&Itgb2 CHO N/A
    Mouse Itgb2-3605M Recombinant Mouse Itgb2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Itgb2-7145M Recombinant Mouse Itgb2 protein, His & T7-tagged E.coli His/T7
    Rat Itgb2-7146R Recombinant Rat Itgb2 protein, His & T7-tagged E.coli His/T7
    Chicken ITGB2-6803C Recombinant Chicken ITGB2 Mammalian Cell His

    itgb2 involved in several pathways and played different roles in them. We selected most pathways itgb2 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with itgb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway PIK3CA; MAGI2; ITGAM; Kitl; FGF6; INS1; PDGFB; PLCB4; F2R; PGF
    Phagosome CTSL1B; HLA-DOA; TUBAL3; THBS4; TUBA8L; DYNC2H1; TLR4BB; Cd209g; BMA2; ATP6V1A
    Hippo signaling pathway LEF1; LLGL2; BMP8B; WNT4; TGFB2; FZD5; WNT16; WNT9A; WWTR1; Fzd4
    Cell adhesion molecules (CAMs) CLDN15LB; VTCN1; NCAM2; SELP; OCLN; Icosl; NTNG1; BMA1; CD8A; NLGN4X
    Natural killer cell mediated cytotoxicity SH2D1A; PRKCA; PIK3CD; FASLG; Raet1a; KIR2DS2; ULBP2; PTPN6; BRAF; VAV1
    Leukocyte transendothelial migration PIK3CG; CDH5; ROCK2; PIK3R1; PIK3R5; PLCG2; VAV2; TXK; CD99; NIPAL1
    Regulation of actin cytoskeleton WASL; MAP2K2A; ACTN2; ITGB7; ITGA10; PPP1R12C; PDGFD; PPP1CC; MAPK6; PAK7
    Pertussis C1QC; IL12A; Hc; ITGB2; PYCARD; C4BP; C1RA; NLRP3; CXCL6; C3
    Legionellosis CASP7; RAB1; SAR1B; EEF1A2; VCP; NFKBIA; IL12B; CR1; RAB1A; MYD88
    Malaria SELE; TGFB2; CCL2; CD40LG; TLR9; ITGB2L; THBS4; HBA-A2; LRP1; IFNG
    Staphylococcus aureus infection ITGB2; C5; HLA-DRB3; DSG1C; HLA-DRB4; PTAFR; GM5077; FPR1; Hc; HLA-DOA
    Tuberculosis HLA-DRB3; Ifna15; HLA-DRB1; PPP3CC; IFNA7; FCGR3; Pla2r1; IFNA14; RAB5B; CD209
    HTLV-I infection POLE2; GPS2; NFATC4; H2-Q10; SLC25A5; ATF3; HLA-C; NFATC2; MAP3K1; PDGFB
    Rheumatoid arthritis Il23a; Il12b; H2-AA; CCL5; TGFB3; HLA-DRA; IL17A; ITGAL; HLA-DPB1; ATP6V0A4; CXCL1
    Viral myocarditis HLA-DQA1; ABL2; EIF4G3; MYH7; CASP9; CD40LG; ITGB2; H2-AA; ACTB; CASP8

    itgb2 has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itgb2 itself. We selected most functions itgb2 had, and list some proteins which have the same functions with itgb2. You can find most of the proteins on our site.

    Function Related Protein
    ICAM-3 receptor activity ITGB2; CLEC4M; ITGAL
    cell adhesion molecule binding CD1D; NCR3; PVRL3; AMICA1; GRIN2A; CADM1B; NLGN1; PKP3; CADM1A; VCAM1
    glycoprotein binding CD4; FBXO2; STX1A; HSPA5; OS9; SDCBP; RAB14; APOH; SDC1; ACE2
    metal ion binding ASH2L; RNASEL; ZNF41; MTBL; ZFP451; TOPAZ1; MBNL1; DMRTA1; DGKQ; OAS1
    protein binding RGS19; GTF2A2; KIF5B; IFNAR2; RGS17; ZNF79; GNGT1; HOXA9; PIP5K1A; TAB2
    protein kinase binding RCC2; PLK1; FGR; CCNYL1; JTB; RPS19; NEK6; AXIN2; TRAF2; STK39

    itgb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itgb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of itgb2.


    Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
    Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).

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