Active Recombinant Full Length Human ITGB2 Protein, C-Flag-tagged

• Cat.No.: ITGB2-248HFL
• Product Overview: Recombinant Full Length Human ITGB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Far-Western blot
  ELISA binding assay
• Molecular Mass: 82.5 kDa
• AA Sequence: MLGLRPPLLALVGLLSLGCVLSQEC TKFKVSSCRECIESGPGCTWCQKLN FTGPGDPDSIRCDTRPQLLM RGCAADDIMDPTSLAETQEDHNGGQ KQLSPQKVTLYLRPGQAAAFNVTFR RAKGYPIDLYYLMDLSYSML DDLRNVKKLGGDLLRALNEITESGR IGFGSFVDKTVLPFVNTHPDKLRNP CPNKEKECQPPFAFRHVLKL TNNSNQFQTEVGKQLISGNLDAPEG GLDAMMQVAACPEEIGWRNVTRLLV FATDDGFHFAGDGKLGAILT PNDGRCHLEDNLYKRSNEFDYPSVG QLAHKLAENNIQPIFAVTSRMVKTY EKLTEIIPKSAVGELSEDSS NVVQLIKNAYNKLSSRVFLDHNALP DTLKVTYDSFCSNGVTHRNQPRGDC DGVQINVPITFQVKVTATEC IQEQSFVIRALGFTDIVTVQVLPQC ECRCRDQSRDRSLCHGKGFLECGIC RCDTGYIGKNCECQTQGRSS QELEGSCRKDNNSIICSGLGDCVCG QCLCHTSDVPGKLIYGQYCECDTIN CERYNGQVCGGPGRGLCFCG KCRCHPGFEGSACQCERTTEGCLNP RRVECSGRGRCRCNVCECHSGYQLP LCQECPGCPSPCGKYISCAE CLKFEKGPFGKNCSAACPGLQLSNN PVKGRTCKERDSEGCWVAYTLEQQD GMDRYLIYVDESRECVAGPN IAAIVGGTVAGIVLIGILLLVIWKA LIHLSDLREYRRFEKEKLKSQWNND NPLFKSATTTVMNPKFAESTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis

Gene Information

• Gene Name: ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]
• Official Symbol: ITGB2
• Synonyms: LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
• Gene ID: 3689
• mRNA Refseq: NM_001127491.3
• Protein Refseq: NP_001120963.2
• MIM: 600065
• UniProt ID: P05107