ITGB3

  • Official Full Name

    integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

  • Overview

    The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
  • Synonyms

    GT; CD61; GP3A; BDPLT2; GPIIIa; integrin beta-3; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; CD41; CD41b; GP 2B; GP IIb; GTA; HPA3; Integrin alpha 2b; ITGA2B; ITGB3; Tadocizumab; 339086-80-5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human cells
  • Human plasma
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Strep
  • DYKDDDDK
  • Flag
  • His (Fc)
  • Avi
  • His|Avi
  • His|S
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGB3-12H Recombinant Human ITGB3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ITGB3-16H Recombinant Human ITGB3 Protein, His-tagged E.coli His
Human ITGB3-6740H Recombinant Human ITGB3 protein, His-tagged E.coli His Asp135~Ile377
Human ITGAV&ITGB3-739H Recombinant Human ITGAV/ITGB3 protein, His-tagged HEK293 His Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3)
Human ITGB3-5124HCL Recombinant Human ITGB3 293 Cell Lysate HEK293 N/A
Human ITGAV & ITGB3-738H Active Recombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGB3-11H Native Human GPIIbIIIa Human plasma N/A
Human ITGB3-2555H Recombinant Human ITGB3 protein(631-700 aa), C-His-tagged HEK293 C-His 631-700 aa
Human ITGB3-151H Recombinant Human ITGB3 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human ITGB3-2940H Recombinant Human ITGB3 protein, His-tagged E.coli His 634-718 aa
Human ITGB3-4733H Recombinant Human ITGB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGb3-3269H Recombinant Human ITGb3 protein, His-tagged HEK293 His Gly27~Asp135
Human ITGB3-5921HFL Recombinant Full Length Human ITGB3 protein, Flag-tagged Mamanlian cells Flag
Human ITGB3-4327H Recombinant Human ITGB3 Protein (Met1-Asp718), C-His tagged Mammalian cells C-His Met1-Asp718
Human ITGB3-1165H Recombinant Human ITGB3 Protein (Glu134-Glu384), N-His tagged E.coli N-His Glu134-Glu384
Human ITGB3-2554H Recombinant Human ITGB3 protein(621-700 aa), C-His-tagged E.coli C-His 621-700 aa
Human ITGB3-2373H Recombinant Human ITGB3 Protein (Met1-Asp718), C-Strep tagged Mammalian cells C-Strep Met1-Asp718
Mouse ITGB3-8366M Recombinant Mouse ITGB3 Protein Mammalian Cell His
Mouse Itgb3-6741M Recombinant Mouse Itgb3 protein, His & S-tagged E.coli His/S Asp135~Ile377 (Accession # O54890)
Mouse ITGB3-4645M-B Recombinant Mouse ITGB3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Itgb3-3606M Recombinant Mouse Itgb3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ITGB3-4645M Recombinant Mouse ITGB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL5328HF Recombinant Full Length Human Integrin Beta-3(Itgb3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-788)
Mus musculus (Mouse) RFL9745MF Recombinant Full Length Mouse Integrin Beta-3(Itgb3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-787)
Chicken ITGB3-5888C Recombinant Chicken ITGB3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ITGB3 involved in several pathways and played different roles in them. We selected most pathways ITGB3 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayRAF1;GNAS;PDGFRB;LAT;LPAR5;PLCB4;Adcy4;PRKD3;PIK3CD
PhagosomeCTSSA;CALRL2;EEA1;HLA-DRB4;ITGB1B.2;MRC2;TUBA1C;HLA-DQA1;ATP6V0E1
PIK-Akt signaling pathwayYWHAG;LAMA5;KLK1B4;ITGB1;RPS6KB2;CD19;MTCP1;G6PC2;FGF11
Osteoclast differentiationMAPK11;PPARG;LILRA5;FOS;MAP3K7;NOX3;PIK3CB;LILRA3;MAPK9
Focal adhesionPARVAA;VASP;PDGFRB;PDPK1;COL2A1;COL6A6;LAMA2;MAPK8B;PDGFD
ECM-receptor interactionTNN;ITGA2;LAMB3;COMP;ITGB3B;CD44;Itga10&Itgb1;COL11A2;VTNA
Platelet activationP2RY12;TLN1;GNAI1;PLA2G4F;GNAS;RAP1B;MAPK1;FCGR2A;ITGA2
Hematopoietic cell lineageIL7;CD2;CD7;CD1E;CSF1;CSF3;CD1d1;CD1B;CD1E, B2M
Regulation of actin cytoskeletonROCK2A;ACTB2;MYL9A;PFN1;FGF18;GNA13A;ACTN2B;ROCK2B;FGF1B
Thyroid hormone signaling pathwayPIK3R2;HRAS;PRKACG;ATP1A3;AKT1;CCND1;RXRG;GSK3B;MED12
Proteoglycans in cancerPPP1R12A;ELK1;PPP1CA;MAPK12;MAP2K2;CD44;GRB2;Fasl;CAMK2G
MicroRNAs in cancerRPTOR;MMP9;TPM1;CDC25C;HOXD10;STAT3;EFNA3;MAP2K2;MDM4
Hypertrophic cardiomyopathy (HCM)CACNG7;ITGB5;CACNG4;ITGA2B;MYL2;TGFB3;ITGB7;CACNG8;ITGA8
Arrhythmogenic right ventricular cardiomyopathy (ARVC)DMD;LAMA2;CACNA2D3;GJA1;ITGA3;CACNA2D1;CACNG1;ITGB7;ITGA2
Dilated cardiomyopathySGCD;ADRB1;MYBPC3;ITGB7;Adcy4;CACNG4;ITGB4;LMNA;MYH7

ITGB3 has several biochemical functions, for example, cell adhesion molecule binding, enzyme binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3 itself. We selected most functions ITGB3 had, and list some proteins which have the same functions with ITGB3. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingLPHN1;SMAGP;CD200;ITGA4;CADM4;GLYCAM1;NLGN3;PVRL2;POSTNB
enzyme bindingTAL1;CAD;GNB2L1;MTA1;EIF4E;TSPAN17;HYAL2;CD40;PHB
extracellular matrix bindingDMP1;TGFBI;SID4;VEGFA;CYR61;CD248;FBLN2;GPR56;SPP1
fibronectin bindingMMP13;CTGF;VEGFA;FSTL3;IGFBP5;LPA;IGFBP5A;CCDC80;SDC4
identical protein bindingTRP53;GOT2;MCM10;CDC42BPA;CCL4;APIP;ACPP;AGER;ACTB
platelet-derived growth factor receptor bindingITGA5;PTPRJ;Pdgfa&Pdgfb;VEGFA;PDGFAA;PDGFB;PDGFAB;PDGFRB;PDGFA
protease bindingSerpina1b;SEMG2;SERPINA5;BCL10;ITGA3;THAP5;PINK1;DPP4;CAST
protein bindingIGFBP5;PAGE5;ELN;C17orf28;TUFM;GSTM5;ATF1;CD28;IRAK2
protein disulfide isomerase activityPDIA2;TMX1;QSOX1;PDILT;TXNDC11;TMX3;ITGB3;PDIA6;TXNDC5
vascular endothelial growth factor receptor 2 bindingPDCL3;ITGB3;ITGA5;GREM1;VEGFA
virus receptor activityCD46;HTR2A;ITGB5;DPP4;TNFRSF14;GYPA;ITGB1;MOG;HSPA1B

ITGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3.

ITGAV; ITGA2B

Research Area

Related articles

Regassa, A; Kim, WK; et al. Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC GENOMICS 16:-(2015).
Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Where does ITGB3 exist? 08/16/2022

ITGB3 is mainly found on the surface of PLT and megakaryocytes.

What are the biological functions of ITGB3? 04/07/2022

ITGB3 is involved in the regulation of embryonic development, wound healing, coagulation and hemostasis, and immune response.

ITGB3 is closely associated with the study of which diseases? 03/30/2021

ITGB3 is strongly associated with research into diseases such as colon and prostate cancer.

What are the subtypes of ITGB3? 03/14/2021

There are two types of ITGB3, αvβ3 and αIIbβ3.

What are the consequences of ITGB3 deficiency? 01/14/2021

ITGB3 deficiency led to reduced differentiation of circulating angiogenic cells, as well as reduced adhesion to the subendothelial membrane of injured endothelial cells, the unable to bind to fibrinogen, increasing the risk of vascular leakage or bleeding.

Customer Reviews (3)

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Reviews
02/06/2023

    The technician modified my experimental protocol so that my experiment went smoothly.

    11/14/2022

      Very good after-sales service to get my experiments going!

      04/01/2022

        The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

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