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Official Full Name integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Background The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Synonyms GT; CD61; GP3A; BDPLT2; GPIIIa; integrin beta-3; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; CD41; CD41b; GP 2B; GP IIb; GTA; HPA3; Integrin alpha 2b; ITGA2B; ITGB3; Tadocizumab; 339086-80-5
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human plasma
    • Mammalian Cell
    • Tag :
    • His
    • Avi
    • S
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGAV & ITGB3-738H Recombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAV&ITGB3-739H Recombinant Human ITGAV/ITGB3 protein, His-tagged HEK293 His
    Human ITGB3-11H Native Human GPIIbIIIa Human plasma N/A
    Human ITGB3-12H Recombinant Human ITGB3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ITGB3-16H Recombinant Human ITGB3 protein, His/S-tagged E.coli His/S
    Human ITGB3-5124HCL Recombinant Human ITGB3 293 Cell Lysate HEK293 N/A
    Human ITGB3-6740H Recombinant Human ITGB3 protein, His-tagged E.coli His
    Mouse Itgb3-6741M Recombinant Mouse Itgb3 protein, His & S-tagged E.coli His/S
    Mouse ITGB3-8366M Recombinant Mouse ITGB3 Protein Mammalian Cell His
    Chicken ITGB3-5888C Recombinant Chicken ITGB3 Mammalian Cell His

    itgb3 involved in several pathways and played different roles in them. We selected most pathways itgb3 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with itgb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway NGFR; CDH1; PDGFB; RAC1; RALB; FGF11; PIK3R5; RAPGEF5; PRKCZ; MAP2K1
    Phagosome MHC2A; H2-AA; SEC61G; RAB5C; TUBAL3; TLR2; TUBB2A; ATP6V1G1; RILP; THBS2
    PIK-Akt signaling pathway IL4; TNC; IL7R; ITGA2; GNG7; MLST8; PHLPP1; COL24A1; GNG11; IFNA16
    Osteoclast differentiation NCF1; TNFSF11; LCK; PIK3CB; PPP3CA; FOS; PIK3CA; LILRA5; NFKB1; MAPK8
    Focal adhesion PRKCA; MET; ACTN2; PAK6; CDC42L; PIK3R3; MAPK8; MYLK; BCL2A; COL6A3
    ECM-receptor interaction COL4A5; HMMR; GP6; ITGA7; SDC4; CD36; LAMA4; GP5; VTNB; DAG1
    Platelet activation RHOA; FCER1G; GNAQ; PLCG2; PPP1R12A; STIM1; MYL12A; MAPK13; SRC; COL27A1
    Hematopoietic cell lineage IL9R; CD9; CD5; GM2002; GP9; CD1E, B2M; IL3RA; ITGA5; CD38; ITGA2
    Regulation of actin cytoskeleton ARHGEF12; Fgf15; ITGB5; FGF18A; ACTN2; BDKRB1; ABI2A; WASL; FGF9; BAIAP2A
    Thyroid hormone signaling pathway HDAC2; ATP1A3; DIO3; ATP1A2; PLCB2; SLC16A10; MDM2; NRAS; PDPK1; PIK3R1
    Proteoglycans in cancer FZD7; SDC4; HPSE2; MAPK13; PRKCB; NANOG; PIK3CG; ERBB3; DDX5; PLAUR
    MicroRNAs in cancer PRKCE; TNR; CCNE1; HOXD10; MAP2K1; WNT3; TPM1; PTGS2; ABCC1; SLC7A1
    Hypertrophic cardiomyopathy (HCM) ITGB4; PRKAG2; ITGB1; ITGA7; DES; TPM3; SGCD; IGF1; CACNA2D4; ACE
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ACTN2; CACNB2; ITGA10; DAG1; ITGB7; SGCD; JUP; CTNNA1; ITGA2B; ITGA9
    Dilated cardiomyopathy ADRB1; ITGB1; ITGA9; TTN; SGCD; CACNB2; CACNB3; TGFB2; RYR2; TNNI3

    itgb3 has several biochemical functions, for example, cell adhesion molecule binding, enzyme binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itgb3 itself. We selected most functions itgb3 had, and list some proteins which have the same functions with itgb3. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding CD226; ITGB1; PVRL4; NRXN3; SELL; LILRB2; ITGB2; PVRL1; NLGN2; PVRL3
    enzyme binding PPP3CB; XRCC1; HLCS; PPP3CA; USF1; BCHE; BACE1; HIST1H2AE; TH; RYR2
    extracellular matrix binding TGFBI; VTN; DCN; SPARC; ITGA2B; SID4; SPOCK2; VEGFA; CD248; ITGB3
    fibronectin binding ITGB1; ITGA3; CTSK; IGFBP5A; ITGAV; IGFBP5B; MFAP2; SFRP2; LRRC15; MMP13
    identical protein binding APLP1; ZNF703; KHDRBS1; SIAH1A; GLUD1; BCHE; PRDX3; MRAP2; CLDND; AHI1
    platelet-derived growth factor receptor binding VEGFA; PDGFAB; PTPRJ; FIGF; ITGA5; PTEN; TYMP; PDGFA; IL1R1; PDGFAA
    protease binding SERPINC1; THAP5; ADRM1; TP53; ITGB3; Cstb; CHL1; FLOT1; IL1R1; CD28
    protein binding ITGB3BP; VTA1; NR1I2; UBD; RAD17; STK16; GABARAPL1; CASP8; ZNF436; PEX11B
    protein disulfide isomerase activity ERP44; PDIA2; TMX3; PDIA5; ZNF169; PDIP5; ERO1LB; ITGB3; P4HB; ERO1L
    vascular endothelial growth factor receptor 2 binding ITGA5; PDCL3; ITGB3; VEGFA; GREM1
    virus receptor activity ITGB1; SIVA1; ACE2; HYAL2; CLEC5A; CCR5; SERPINB3; PVRL1; ICAM1; CXCR4

    itgb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itgb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of itgb3.


    Regassa, A; Kim, WK; et al. Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC GENOMICS 16:-(2015).
    Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).

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