LRRK2

  • Official Full Name

    leucine-rich repeat kinase 2

  • Overview

    This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a;leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain,;and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer;membrane. Mutations in this gene have been associated with Parkinson disease-8.
  • Synonyms

    LRRK2; leucine-rich repeat kinase 2; PARK8, Parkinson disease (autosomal dominant) 8; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Insect Cell
  • Mammaliaan Cells
  • Sf21
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Wheat Germ
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRRK2-109H Active Recombinant Human LRRK2 (G2385R), GST-tagged Sf9 Insect Cell GST
Human LRRK2-108H Active Recombinant Human LRRK2 (G2019S), GST-tagged Sf9 Insect Cell GST
Human LRRK2-110H Active Recombinant Human LRRK2 (I2020T), GST-tagged Sf9 Insect Cell GST
Human LRRK2-33H Active Recombinant Human LRRK2 Protein, FLAG-tagged Mammaliaan Cells FLAG
Human LRRK2-115H Active Recombinant Human LRRK2 (Y1699C) Protein, GST-tagged Insect Cell GST
Human LRRK2-117H Active Recombinant Human LRRK2 Protein, GST-tagged Insect Cell GST
Human LRRK2-114H Active Recombinant Human LRRK2 (R1441H) Protein, GST-tagged Insect Cell GST
Human LRRK2-111H Active Recombinant Human LRRK2 (D1994A) Protein, GST-tagged Insect Cell GST
Human LRRK2-116H Active Recombinant Human LRRK2 (Y1699G) Protein, GST-tagged Insect Cell GST
Human LRRK2-112H Active Recombinant Human LRRK2 (R1441C) Protein, GST-tagged Insect Cell GST
Human LRRK2-113H Active Recombinant Human LRRK2 (R1441G) Protein, GST-tagged Insect Cell GST
Human LRRK2-127H Active Recombinant Human LRRK2(970-end) Protein, N-Flag-tagged Sf21 Flag 970-end
Human LRRK2-35HCL Recombinant Human LRRK2 HEK293T cell lysate HEK293 Myc/DDK
Human LRRK2-4634H Recombinant Human LRRK2 Protein, GST-tagged Wheat Germ GST
Human LRRK2-1320H-B Recombinant Human LRRK2 Protein Pre-coupled Magnetic Beads HEK293
Human LRRK2-1553H Recombinant Human LRRK2 protein, His-tagged E.coli His Phe1479~Pro1729 (Accession # Q5S007)
Human LRRK2-22H Recombinant Active Human LRRK2 (I1371V) Protein (968-end), N-GST-tagged Sf9 insect cells N-GST 968-end
Human LRRK2-1320H Recombinant Human LRRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LRRK2-3706H Recombinant Human LRRK2 Protein (Phe1479-Pro1729), His tagged E.coli His Phe1479-Pro1729
Mouse Lrrk2-1555M Recombinant Mouse Lrrk2 protein, His & GST-tagged E.coli His/GST Leu761~Leu994 (Accession # Q5S006)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

LRRK2 involved in several pathways and played different roles in them. We selected most pathways LRRK2 participated on our site, such as MAPK signaling pathway, Parkinsons disease, Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNA1SB;CACNB1;FGF3;MAPK14A;RASGRP3;FGF18A;MAP3K4;FGFR1A;MAP2K4A
Parkinsons diseaseNDUFB6;PINK1;SLC25A4;PRKACG;HTRA2;NDUFB4;ATP5O;SDHA;UBA1
Parkinsons Disease PathwayPARK7;UBE2J2;ATXN2;SYT11;LRRK2
Wnt Signaling Pathway and PluripotencyFOXD3;PPM1J;LRRK2;FBXW2;ZBTB33

LRRK2 has several biochemical functions, for example, ATP binding, GTP binding, GTP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRRK2 itself. We selected most functions LRRK2 had, and list some proteins which have the same functions with LRRK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKCNJ8;PDPK1A;UBE2D1B;NMRK1;NAIP6;CDK13;PRKACA;NPR1;H1FNT
GTP bindingRERGLA;GIMAP7;RHOC;RAB18A;DAPK1;ARF3B;RND1L;RRAD;RTKN
GTP-dependent protein kinase activityALPK2;LRRK2
GTPase activator activityTBC1D9B;RAP1GAP2A;ARHGAP4A;PLCB1;RGS5;CDC42EP5;RGS13;SGSM2;ARHGAP35
GTPase activityRAB26;HRAS;RRAS2;RAB39BA;IFT22;ARL8A;RAB7;EIF5B;MXC
MAP kinase kinase activityMAP2K2A;MAP3K20;MAP2K2;MAPKAPK5;MAP2K3;SBK3;LRRK2;MAPK14;PAK3
Rho GTPase bindingDIAP3;CSDA;FMNL2;LRRK2;DIAPH3;ROCK2;ROCK2A;DOCK10;DOCK11
SNARE bindingGOSR2;SYT1;STX3A;MYO5A;STX4A;NBAS;GABARAPL2;SYBL1;VTI1B
actin bindingMICAL1;MYH11A;KLHL2;TNS1;CNN1;MTSS1L;EPB41L3B;DAAM1B;SPATA31
beta-catenin destruction complex binding
clathrin bindingTOM1L1;SYT1A;CLINT1;LRRK2;AFTPHA;PICALMB;SYT1B;SYT13;SYT4
glycoprotein bindingRGMA;PTBP3;CSNK1D;ITGB2;BMPR1B;FGFR1;HFE2;LRRK2;CDH1
identical protein bindingPCBD1;GSTM3;PRPF3;OMG;PAK2;ERBB3;ACPP;C1S;DES
ion channel bindingKCNE2;TCAP;YWHAH;ID2;AKAP9;CALM1;CAMK2D;PDE4B;CALM
kinase activityCAMK1GB;TAOK1;PIP5K1AA;SGMS1;PTK6B;SBK3;EK1;GM4922;ERBB3B
peroxidase inhibitor activity
protein bindingDOCK1;TRIP6;MYO18A;ZFYVE19;DDR2;PTPN11A;GPAA1;HNRNPM;KIF23
protein homodimerization activityGOLGA5;GPD1L;TYR;PSMD7;PVRL4;Il6ra;GSTZ1;Flt3l;SLC4A1
protein kinase A bindingAKAP7;AKAP13;AKAP17A;AKAP6;Akap3;AKAP12;DACT1;AKAP14;MYRIP
protein kinase activityROCK1;DCKL1B;ROCK2A;SMOK2B;NTRK2B;MAP2K2B;GC2;CHUK;EPHA4B
protein serine/threonine kinase activityRAF1A;SRPK1;SIK2A;RPS6KA1;MLKL;PRKCD;MAPK12A;CSNK1G2A;MINK1
receptor signaling complex scaffold activityCD3G;GRIP1;LRRK2;G3BP2;NCK1;NCK2;MMS19;AXIN1;ROPN1B
syntaxin-1 bindingSNAP25;STXBP3A;CCDC167;LRRK2;CPLX1;RNF40;SNAP25A;SNPH;STXBP1
tubulin bindingALDOA;RABGAP1;MAP1S;NCALD;STMN4;STMN4L;CENPJ;LRRK2;PRNP

LRRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRRK2.

N/A

Research Area

Related articles

West, AB; Cowell, RM; et al. Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents. JOURNAL OF COMPARATIVE NEUROLOGY 522:2465-2480(2014).
Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
08/07/2022

    It has an inhibitory or killing effect on specific pathogens.

    10/26/2019

      High sensitivity and specificity were found in biosensor preparation.

      02/14/2019

        Good selectivity for specific disease-related targets.

        Q&As (6)

        Ask a question
        What is the relationship between LRRK2 gene mutations and neurodevelopment? 11/30/2019

        LRRK2 gene mutations may play an important role in neurodevelopment, including neural precursor cell fate determination, cell migration, and axon clumping.

        What are the effects of LRRK2 gene mutations on other diseases? 10/21/2019

        In addition to Parkinson's disease, LRRK2 gene mutations are also associated with an increased risk of other diseases, such as Crohn's disease, leukemia and cancer.

        How to assess the prognostic impact of LRRK2 gene mutations on patients with Parkinson's disease? 08/30/2019

        By analyzing the clinical and genetic data of a large number of patients, the impact of LRRK2 gene mutations on the prognosis of Parkinson's disease patients, such as age of onset, clinical symptoms, and disease progression, can be evaluated.

        How do mutations in LRRK2 affect Parkinson's disease? 07/20/2019

        LRRK2 gene mutations may complicate the pathogenesis of Parkinson's disease, including increased apoptosis, affecting vesicles, mitochondria, and autophagy function.

        Do drugs that inhibit LRRK2 proteins have potential value in treating Parkinson's disease? 06/12/2019

        Drugs that inhibit LRRK2 protein have potential value in the treatment of Parkinson's disease, but are still in clinical research and further research is needed on their efficacy and safety.

        What are the ways to study the function and regulation of LRRK2 protein? 05/05/2019

        The function and regulation of LRRK2 can be studied using different research methods such as cell culture models, mouse models, fruit fly models, and human induced pluripotent stem cells.

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