LRRK2
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Official Full Name
leucine-rich repeat kinase 2
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Overview
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a;leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain,;and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer;membrane. Mutations in this gene have been associated with Parkinson disease-8. -
Synonyms
LRRK2; leucine-rich repeat kinase 2; PARK8, Parkinson disease (autosomal dominant) 8; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- E.coli
- HEK293
- Insect Cell
- Mammaliaan Cells
- Sf21
- Sf9 Insect Cell
- Sf9 insect cells
- Wheat Germ
- Flag
- FLAG
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
LRRK2 involved in several pathways and played different roles in them. We selected most pathways LRRK2 participated on our site, such as MAPK signaling pathway, Parkinsons disease, Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF18;FAS;FGF1B;MAP2K2;FOS;MKNK2A;MAP3K11;JIP1;RASGRF2B |
| Parkinsons disease | COX8C;NDUFB3;NDUFA3;NDUFA9;GNAI3;PINK1;UBA7;UBE2G2;NDUFC2 |
| Parkinsons Disease Pathway | PARK7;LRRK2;UBE2J2;ATXN2;SYT11 |
| Wnt Signaling Pathway and Pluripotency | FOXD3;LRRK2;ZBTB33;FBXW2;PPM1J |
LRRK2 has several biochemical functions, for example, ATP binding, GTP binding, GTP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRRK2 itself. We selected most functions LRRK2 had, and list some proteins which have the same functions with LRRK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NWD1;CERK;PTK6;ATP1A1;MYO5A;PLK4;OAS2;HSPA4B;ATP6V1AA |
| GTP binding | EEF1A1L1;RAB11A;RP2;RAB3AA;NOA1;HRAS;EIF2B2;RAB12;EIF2B1 |
| GTP-dependent protein kinase activity | ALPK2;LRRK2 |
| GTPase activator activity | RGS18;ARAP3;ACAP3;SRGAP3;RALGAPA1;RANBP1;RALGAPA2;TBC1D9;RGS12 |
| GTPase activity | LGALS6;RAB42A;RAB26;TUBG1;RAB1BB;RALBB;ARL3;RAB11BA;TRIM23 |
| MAP kinase kinase activity | MAP2K2A;PAK3;LRRK2;MAP2K7;MAP2K2B;MAP3K20;SBK3;MAP2K3;MAPK14 |
| Rho GTPase binding | RHOH;ANTXR2A;CSDA;ROCK2;FLNA;INF2;DAAM1;DAPK3;ARHGEF2 |
| SNARE binding | SNAPIN;CAPN10;STX11B.2;STX4;TRIM9;SEC22BA;UVRAG;EXOC3L;VAMP2 |
| actin binding | SPTAN1;SPIRE2;FSCN2B;CNN1A;SSH2B;GSNB;ACTR3B;CAPZA2;INPPL1B |
| beta-catenin destruction complex binding | |
| clathrin binding | DOC2B;SYT1B;SYT8;SYTL4;SYT1;SYT5A;DOC2D;SYT17;SYT5 |
| glycoprotein binding | LRRK2;EDEM2;ERBB2;ITGA3;AZGP1;SHB;CNTN1;PLAT;FYN |
| identical protein binding | ADIPOR1;TARDBP;PFKFB1;PSMD4;SID4;TRP63;CLDN20;CUBN;TLE1 |
| ion channel binding | CIB1;FYN;CAV3;YWHAH;PHPT1;SUMO1;PACS1A;YES1;ABCC9 |
| kinase activity | BSK146;STK38A;CDK5R1B;HMGXB3;NEK1;CAMK1GB;CKMT1;TNK2B;CDKL5 |
| peroxidase inhibitor activity | |
| protein binding | PICALM;C10orf81;PPIAL4A;USP12;ECSIT;STOML2;AHR;C9orf86;TGFBR2 |
| protein homodimerization activity | NFKB1;PDCD6IP;SPATA24;CARS;PRMT8;GLA;ANXA9;NAMPT;GM5506 |
| protein kinase A binding | AKAP7;MYRIP;DACT1;AKAP12B;RPS3;AKAP14;Akap3;AKAP5;AKAP13 |
| protein kinase activity | GUCY2F;ACVR1L;EPHA1;TSSK1;DCLK1A;MAPK12A;GM4922;PANK1A;PINK1 |
| protein serine/threonine kinase activity | TBK1;PIK3CG;TNK2;STK38A;RIOK1;RIOK3;MAP3K8;NEK8;Aatk |
| receptor signaling complex scaffold activity | LRRK2;MMS19;MAPK8IP3;SHANK1;GRIP2A;SPAG9A;NUP62;ROPN1B;DEDD2 |
| syntaxin-1 binding | RNF40;SNPH;SLC6A4;SYBU;SNAP25;NSF;VAMP2;LRRK2;STXBP3 |
| tubulin binding | STMN1A;VBP1;GPAA1;CLIP1;PRNP;MTAP7D3;STMN1B;TBCC;STMN4 |
LRRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRRK2.
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Research Area
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Customer Reviews (3)
Write a reviewIt has an inhibitory or killing effect on specific pathogens.
High sensitivity and specificity were found in biosensor preparation.
Good selectivity for specific disease-related targets.
Q&As (6)
Ask a questionLRRK2 gene mutations may play an important role in neurodevelopment, including neural precursor cell fate determination, cell migration, and axon clumping.
In addition to Parkinson's disease, LRRK2 gene mutations are also associated with an increased risk of other diseases, such as Crohn's disease, leukemia and cancer.
By analyzing the clinical and genetic data of a large number of patients, the impact of LRRK2 gene mutations on the prognosis of Parkinson's disease patients, such as age of onset, clinical symptoms, and disease progression, can be evaluated.
LRRK2 gene mutations may complicate the pathogenesis of Parkinson's disease, including increased apoptosis, affecting vesicles, mitochondria, and autophagy function.
Drugs that inhibit LRRK2 protein have potential value in the treatment of Parkinson's disease, but are still in clinical research and further research is needed on their efficacy and safety.
The function and regulation of LRRK2 can be studied using different research methods such as cell culture models, mouse models, fruit fly models, and human induced pluripotent stem cells.
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