Active Recombinant Human LRRK2 Protein, FLAG-tagged
Cat.No. : | LRRK2-33H |
Product Overview : | Recombinant full length Human LRRK2 protein was expressed in mammalian cells with DYKDDDDK-tag. |
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Description : | Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease. |
Source : | Mammalian cells |
Species : | Human |
Tag : | FLAG |
Form : | 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X–100, 2 mM DTT and 50% Glycerol. |
Bio-activity : | 61 nmoles of phosphate transferred to ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) per minute per mg of total protein at 30 centigrade. Activity determined at a final protein concentration of 2.08 µg/mL. |
Molecular Mass : | 288 kDa |
Purity : | 85% as determined by a Coomassie blue stained SDS-PAGE gel |
Storage : | Store at -80 centigrade |
Concentration : | 0.22 mg/mL total protein as measured using the Bradford protein assay with BSA as a standard. |
Gene Name : | LRRK2 leucine-rich repeat kinase 2 [ Homo sapiens ] |
Official Symbol : | LRRK2 |
Synonyms : | LRRK2; leucine-rich repeat kinase 2; PARK8, Parkinson disease (autosomal dominant) 8; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN |
Gene ID : | 120892 |
mRNA Refseq : | NM_198578 |
Protein Refseq : | NP_940980 |
MIM : | 609007 |
UniProt ID : | Q5S007 |
Products Types
◆ Recombinant Protein | ||
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LRRK2-114H | Active Recombinant Human LRRK2 (R1441H) Protein, GST-tagged | +Inquiry |
LRRK2-113H | Active Recombinant Human LRRK2 (R1441G) Protein, GST-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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