MAP2K6 Protein


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Official Full Name mitogen-activated protein kinase kinase 6
Background MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK.
Synonyms MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK k; SAPKK-3
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Baculovirus-Insect Cells
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His & GST
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K6-176H Active Recombinant Human MAP2K6, GST-tagged E.coli GST
    Human MAP2K6-889H Active Recombinant Human MAP2K6 protein (Met 1-Asp 334 (Ser 207/Asp, Thr 211/Asp)), His & GST-tagged Baculovirus-Insect Cells His & GST
    Human MAP2K6-30189TH Recombinant Human MAP2K6 Insect Cell N/A
    Human MAP2K6-34H Recombinant human biotinylated MAP2K6, His-tagged E.coli His
    Human MAP2K6-47H Recombinant Human MEK6, GST-tagged Sf9 Insect Cell GST
    Human MAP2K6-524H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
    Human MAP2K6-525H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
    Human MAP2K6-888H Recombinant Human MAP2K6, His & GST tagged Insect Cell His/GST
    Human MAP2K6-97H Recombinant Human MAP2K6, His-tagged Insect Cell His
    Mouse MAP2K6-9503M Recombinant Mouse MAP2K6 Protein Mammalian Cell His
    Rhesus Macaque MAP2K6-2665R Recombinant Rhesus monkey MAP2K6 Protein, His-tagged Mammalian Cell His
    Zebrafish MAP2K6-9245Z Recombinant Zebrafish MAP2K6 Mammalian Cell His
    Human MAP2K6-001HCL Recombinant Human MAP2K6 cell lysate Insect Cell N/A
    Human MAP2K6-01H Recombinant Human MAP2K6 Protein, His-tagged Insect Cell His
    Human MAP2K6-2159HF Recombinant Full Length Human MAP2K6 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K6-2241H Recombinant Human MAP2K6 protein, His-tagged Insect Cell His
    Human MAP2K6-3059H Recombinant Human MAP2K6 protein, His-tagged E.coli His
    Human MAP2K6-3203H Recombinant Human MAP2K6 protein, His-SUMO-tagged E.coli His-SUMO
    Human MAP2K6-4007HF Recombinant Full Length Human MAP2K6 Protein, GST-tagged E.coli GST
    Human MAP2K6-9864HF Recombinant Full Length Human MAP2K6 Protein, GST-tagged E.coli GST
    Human MAP2K6-392H Recombinant Human MAP2K6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K6-6391H Recombinant Human MAP2K6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Map2k6-3924M Recombinant Mouse Map2k6 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP2K6 involved in several pathways and played different roles in them. We selected most pathways MAP2K6 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK1; CDC25B; FGF6B; MAPKAPK2A; CACNA1G; DUSP8A; IL1B; CACNA2D2; FGF11A; MAP4K3
    Rap signaling pathway HRAS; PIK3CA; FGF8; MAP2K2; FGF20; VEGFB; PGF; RHOA; ITGB3; KRIT1
    Osteoclast differentiation MITF; PPP3R1; NFATC2; IL1R1; ACP5; CSF1R; FOS; CAMK4; OSCAR; GRB2
    Toll-like receptor signaling pathway TMED7-TICAM2; IL12A; TLR3; IFNAR1; MAP2K2B; AKT1; IRF7; MAPK3; MAPK10; CCL3L1
    Fc epsilon RI signaling pathway LYN; RAF1; LAT; PLCG2; HRAS; BTK; PIK3CA; FYN; RAC2; PIK3CG
    TNF signaling pathway CREB3L1; MAP3K14; FADD; TNFRSF1A; TRAF5; ICAM1; TRADD; MAPK8; MAP2K3; RPS6KA5
    Inflammatory mediator regulation of TRP channels MAPK12; ACCN5; PRKCB; CAMK2D; IL1B; CYP2C39; TRPV2; CYP2C37; HTR2C; PLA2G4F
    GnRH signaling pathway CAMK2G1; CDC42; CALML3; SRC; MAPK14B; GNA11B; GNA11A; PRKACBA; CALM; PLCB3
    Amyotrophic lateral sclerosis (ALS) MAP2K3; BID; BAX; CASP1; TOMM40L; TRP53; CASP12; BCL2L1; ALS2; TP53
    Toxoplasmosis TNF; HLA-DQB1; HSPA1B; TRAF6; LAMC1; IL10RA; BAD; HLA-DRB3; GNAI3; HLA-DQA1
    Epstein-Barr virus infection NFKBIE; MAP2K6; ICAM1; CCNA2; PRKACA; PRKACB; IKBKG; SPN; LYN; POLR2L

    MAP2K6 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K6 itself. We selected most functions MAP2K6 had, and list some proteins which have the same functions with MAP2K6. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activity PAK3; MAP2K1; MAP2K2B; MAP2K6; MAPK10; MAP2K3; MAPKAPK5; MAP2K2; MAP2K2A; SBK3
    protein binding ELK3; MYCBP2; BIN1; MAP3K8; GOPC; TCF7L1A; EIF3M; SH2D3C; TTC8; EDARADD
    protein kinase binding FGR; HDAC7; GYS1; CCNE1; CEP68; SLC12A5; SPRED2; CACNB3; FER; CDK5
    protein serine/threonine kinase activity MASTL; CDK16; MAP3K2; CSNK1DA; PIK3CA; RIOK1; BMPR2A; EIF2AK2; DCAMKL2; RAF1A
    protein tyrosine kinase activity DYRK3; Fert2; WEE2; BMX; SRC; PTK2AB; EGFRA; DYRK1B; ZNF143B; TNK2B

    MAP2K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K6.


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