• Official Full Name

    mitogen-activated protein kinase kinase 6

  • Overview

    MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK.
  • Synonyms

    MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK k; SAPKK-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect Cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K6-176H Active Recombinant Human MAP2K6, GST-tagged E.coli GST
Human MAP2K6-889H Active Recombinant Human MAP2K6 protein (Met 1-Asp 334 (Ser 207/Asp, Thr 211/Asp)), His & GST-tagged Baculovirus-Insect Cells His & GST
Human MAP2K6-525H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
Human MAP2K6-97H Recombinant Human MAP2K6, His-tagged Insect Cell His
Human MAP2K6-888H Active Recombinant Human MAP2K6 protein, His&GST-tagged Insect Cells His/GST
Human MAP2K6-34H Recombinant human biotinylated MAP2K6, His-tagged E.coli His
Human MAP2K6-524H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
Human MAP2K6-30189TH Recombinant Human MAP2K6 Insect Cell N/A
Human MAP2K6-47H Recombinant Human MEK6, GST-tagged Sf9 Insect Cell GST
Human MAP2K6-001HCL Recombinant Human MAP2K6 cell lysate Insect Cell N/A
Human MAP2K6-6391H Recombinant Human MAP2K6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP2K6-9864HF Active Recombinant Full Length Human MAP2K6 Protein, GST-tagged E.coli GST
Human MAP2K6-3059H Recombinant Human MAP2K6 protein, His-tagged E.coli His
Human MAP2K6-01H Recombinant Human MAP2K6 Protein, His-tagged Insect Cell His
Human MAP2K6-2241H Recombinant Human MAP2K6 protein, His-tagged Insect Cell His
Human MAP2K6-440HFL Active Recombinant Full Length Human MAP2K6 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K6-4007HF Active Recombinant Full Length Human MAP2K6 Protein, GST-tagged E.coli GST
Human MAP2K6-1355H-B Recombinant Human MAP2K6 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K6-3203H Recombinant Human MAP2K6 protein, His-SUMO-tagged E.coli His-SUMO
Human MAP2K6-2189H Recombinant Human MAP2K6 protein Insect Cells N/A
Human MAP2K6-1355H Recombinant Human MAP2K6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K6-5007H Recombinant Human MAP2K6 Protein (Phe46-Pro306), N-His tagged E.coli N-His
Human MAP2K6-2159HF Active Recombinant Full Length Human MAP2K6 Protein, GST-tagged Insect (sf21) GST
Human MAP2K6-392H Recombinant Human MAP2K6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse MAP2K6-9503M Recombinant Mouse MAP2K6 Protein Mammalian Cell His
Mouse MAP2K6-5326M-B Recombinant Mouse MAP2K6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Map2k6-3924M Recombinant Mouse Map2k6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP2K6-5326M Recombinant Mouse MAP2K6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP2K6-2665R Recombinant Rhesus monkey MAP2K6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAP2K6-2485R Recombinant Rhesus Macaque MAP2K6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP2K6-2485R-B Recombinant Rhesus Macaque MAP2K6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP2K6-9245Z Recombinant Zebrafish MAP2K6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MAP2K6 involved in several pathways and played different roles in them. We selected most pathways MAP2K6 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTRAF6;HSPA2;FGF22;STMN1B;PPM1NA;FGF12A;Casp3;PAK2A;RAC1A
Osteoclast differentiationPIK3CD;NFKBIA;MAPK3;CYLD;PIK3R3;MAPK1;AKT1;TAB2;BTK
Toll-like receptor signaling pathwayAKT3A;CXCL11;PIK3R3;MAP2K7;MAPK1;MAPK12A;STAT1A;MAP2K2;MAP2K4B
Fc epsilon RI signaling pathwayPRKCA;RAC3;PLCG1;MAP2K4;TNF;NRAS;FCER1G;RAF1;MAPK8
Inflammatory mediator regulation of TRP channelsPRKCE;MAPK11;GNAS;IL1B;HTR2C;MAPK13;Adcy4;CAMK2G;CAMK2A
Amyotrophic lateral sclerosis (ALS)GRIN2D;PRPH;TNFRSF1A;CYCS;PPP3CA;NOS1;DERL1;GRIN2A;MAPK13

MAP2K6 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K6 itself. We selected most functions MAP2K6 had, and list some proteins which have the same functions with MAP2K6. You can find most of the proteins on our site.

Function Related Protein
MAP kinase kinase activityLRRK2;MAP2K1;MAPK10;MAP2K2;MAP2K3;MAPKAPK5;MAP2K7;MAPK14;MAP3K14
protein bindingRBCK1;ISOC1;SENP1;CASQ2;EDEM1;POSTN;FNIP1;SUV420H2;ZNF274
protein kinase bindingMSN;Cd24a;AGTR1A;VDAC1;CCNY;LSM2;ACSL3;TMEM173;CCND1
protein serine/threonine kinase activityBCKDK;BMPR1BB;CAMK2D;STK30;WNK2;TNNI3K;CDK11A;PHKG2;CDC42BPA
protein tyrosine kinase activityWEE1;DSTYK;MET;AXL;ALK;Fert2;BMX;FER;NTRK2B

MAP2K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K6.


  • Q&As
  • Reviews

Q&As (5)

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Is MAP2K6 a potential biomarker for predicting treatment response? 05/02/2022

Its expression levels in certain cancers are being explored as predictive biomarkers to anticipate response to specific therapies.

Is MAP2K6 involved in any other diseases besides cancer? 04/15/2021

Studies also suggest its involvement in cardiovascular diseases and neurological disorders.

How does MAP2K6 relate to drug resistance in cancer treatment? 12/06/2020

MAP2K6 signaling pathways might play a role in drug resistance mechanisms, making it a focus for overcoming therapeutic challenges.

Are there any known diseases associated with MAP2K6 mutations? 11/01/2019

Yes, mutations in MAP2K6 have been linked to certain cancers, including colorectal cancer and lung adenocarcinoma.

Can MAP2K6 inhibition lead to potential side effects? 06/26/2018

As with any targeted therapy, MAP2K6 inhibitors might have side effects, which are under investigation in preclinical and clinical studies.

Customer Reviews (3)

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    I am certain that the MAP2K6 protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.


      The excellent technical support provided by the manufacturer can solve my problem.


        Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the MAP2K6 protein consistently delivers exceptional performance and precise outcomes.

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