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Recombinant Human MKK6, Gly & Pro tagged

Cat.No. : MAP2K6-525H
Product Overview : Recombinant Human MKK6 (NP_002749.2) (Met1-Asp334), fused with two additional amino acids (Gly & Pro) at the N-terminus, was produced in Baculovirus-Insect cells.
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Source : Baculovirus-Insect cells
Species : Human
Tag : Gly & Pro
Predicted N Terminal : Gly
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 8.0.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant human MKK6 consists of 336 amino acids and predicts a molecular mass of 37.6 KDa. The apparent molecular mass of the protein is approximately 37 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens(human) ]
Official Symbol : MKK6
Gene ID : 5608
mRNA Refseq : NM_002758
Protein Refseq : NP_002749
MIM : 601254
UniProt ID : P52564
Chromosome Location : 17q24.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is MAP2K6 a potential biomarker for predicting treatment response? 05/02/2022

Its expression levels in certain cancers are being explored as predictive biomarkers to anticipate response to specific therapies.

Is MAP2K6 involved in any other diseases besides cancer? 04/15/2021

Studies also suggest its involvement in cardiovascular diseases and neurological disorders.

How does MAP2K6 relate to drug resistance in cancer treatment? 12/06/2020

MAP2K6 signaling pathways might play a role in drug resistance mechanisms, making it a focus for overcoming therapeutic challenges.

Are there any known diseases associated with MAP2K6 mutations? 11/01/2019

Yes, mutations in MAP2K6 have been linked to certain cancers, including colorectal cancer and lung adenocarcinoma.

Can MAP2K6 inhibition lead to potential side effects? 06/26/2018

As with any targeted therapy, MAP2K6 inhibitors might have side effects, which are under investigation in preclinical and clinical studies.

Customer Reviews (3)

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Reviews
07/21/2022

    I am certain that the MAP2K6 protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.

    03/23/2022

      The excellent technical support provided by the manufacturer can solve my problem.

      12/27/2021

        Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the MAP2K6 protein consistently delivers exceptional performance and precise outcomes.

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