Active Recombinant Human MAP2K6, GST-tagged
Cat.No. : | MAP2K6-176H |
- Specification
- Gene Information
- Related Products
Cat. No. : | MAP2K6-176H |
Description : | N-terminal GST-tagged full-length protein. MKK6 is one of the major specific activators of p38. MAP kinase kinases (MAPKKs) MKK3 and MKK6 are the primary regulators of p38 phosphorylation and activation. The MKK6/p38 pathway is well documented in the regulation of apoptosis. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway regulates the production of interleukin-1 and tumor necrosis factor-alpha. The recombinant human MKK6 was expressed inE. coliand purified by glutathione sepharose chromatography. It is suitable for labeling MKK6 substrates. The highly active form is produced by two amino acid exchanges (S151E, T155E). The sequence based calculated molecular weight is 63.64 kDa. |
Source : | E. coli. |
Form : | Supplied in 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 1 mM DTT and 270 mM sucrose. |
Purity : | > 95% by SDS-PAGE. |
Activity : | > 50,000 U/mg (1 Unit is defined as the amount of MKK6 which activates inactive p38α/SAPK2a (0.5 mg/ml) by 1 U/min using 125 μM ATP at 30 °C. 1 Up38α/SAPK2a activity is defined as 1 picomole phosphate transferred to myelin basic protein per min at 30 °C). |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles. |
Gene Name : | MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens ] |
Synonyms : | MAP2K6; mitogen-activated protein kinase kinase 6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); EC 2.7.12.2; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6 |
Gene ID : | 5608 |
mRNA Refseq : | NM_002758 |
Protein Refseq : | NP_002749 |
MIM : | 601254 |
UniProt ID : | P52564 |
Chromosome Location : | 17q |
Pathway : | Amyotrophic lateral sclerosis (ALS); Fc epsilon RI signaling pathway; GnRH signaling pathway; MAPK signaling pathway; Toll-like receptor signaling pathway |
Function : | ATP binding; MAP kinase kinase ; activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
Map2k6-3924M | Recombinant Mouse Map2k6 Protein, Myc/DDK-tagged | +Inquiry |
MAP2K6-392H | Recombinant Human MAP2K6 Protein, MYC/DDK-tagged | +Inquiry |
MAP2K6-1355H | Recombinant Human MAP2K6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K6-01H | Recombinant Human MAP2K6 Protein, His-tagged | +Inquiry |
MAP2K6-5326M | Recombinant Mouse MAP2K6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MAP2K6-001HCL | Recombinant Human MAP2K6 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIts expression levels in certain cancers are being explored as predictive biomarkers to anticipate response to specific therapies.
Studies also suggest its involvement in cardiovascular diseases and neurological disorders.
MAP2K6 signaling pathways might play a role in drug resistance mechanisms, making it a focus for overcoming therapeutic challenges.
Yes, mutations in MAP2K6 have been linked to certain cancers, including colorectal cancer and lung adenocarcinoma.
As with any targeted therapy, MAP2K6 inhibitors might have side effects, which are under investigation in preclinical and clinical studies.
Customer Reviews (3)
Write a reviewI am certain that the MAP2K6 protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.
The excellent technical support provided by the manufacturer can solve my problem.
Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the MAP2K6 protein consistently delivers exceptional performance and precise outcomes.
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