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  • Official Full Name

    mitogen-activated protein kinase kinase kinase 5

  • Overview

    Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
  • Synonyms

    MAP3K5; mitogen-activated protein kinase kinase kinase 5; ASK1; MEKK5; MAPKKK5; apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; OTTHUMP00000017275; MAP/ERK kinase kinase 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • GST,His
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K5-578H Active Recombinant Human MAP3K5, GST-tagged Sf9 Insect Cell GST
Human MAP3K5-25H Active Recombinant Human MAP3K5(649-946) Protein, N-GST,C-His-tagged E. coli GST,His 649-946 aa
Human MAP3K5-63H Recombinant Human MAP3K5 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human MAP3K5-1260H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 5, GST-tagged Insect Cell GST
Human MAP3K5-11H Recombinant Human MAP3K5 protein, His-tagged E.coli His Gly681~Glu936
Human MAP3K5-245H Recombinant Human MAP3K5, GST-tagged, Active Sf9 Insect Cell GST
Human MAP3K5-20H Recombinant Human MAP3K5 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP3K5-26518TH Recombinant Human MAP3K5 N/A
Human MAP3K5-4504HCL Recombinant Human MAP3K5 293 Cell Lysate HEK293 N/A
Human MAP3K5-361HFL Recombinant Full Length Human MAP3K5 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP3K5-1093H Recombinant Human MAP3K5 Protein (M649-K946), GST/His tagged E.coli GST/His M649-K946
Human MAP3K5-1092H Recombinant Human MAP3K5 Protein (M649-K946), His tagged E.coli His M649-K946
Human MAP3K5-1359H Recombinant Human MAP3K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP3K5-1359H-B Recombinant Human MAP3K5 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAP3K5-9515M Recombinant Mouse MAP3K5 Protein Mammalian Cell His
Mouse ASK1-3585M Recombinant Mouse ASK1, His-tagged, T7 tagged E.coli His/T7 1380
Mouse MAP3K5-5333M Recombinant Mouse MAP3K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Map3k5-3931M Recombinant Mouse Map3k5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP3K5-5333M-B Recombinant Mouse MAP3K5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP3K5-7528Z Recombinant Zebrafish MAP3K5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP3K5 Related Articles
  • MAP3K5 Related Research Area

MAP3K5 involved in several pathways and played different roles in them. We selected most pathways MAP3K5 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwayGNAI2;MAPK10;SPTLC1;GAB2;SGPP1;PPP2R2B;PPP2R5C;SMPD2;BID
Protein processing in endoplasmic reticulumBCAP31;DNAJB1;HSP70;DNAJB12A;ERN1;EIF2AK3;BAG2;EIF2AK2;EDEM2
Neurotrophin signaling pathwayIKBKB;CAMK2A;CALM1;RPS6KA5;SHC1;MAPK11;PTPN11;ATF4;RELA
Non-alcoholic fatty liver disease (NAFLD)PPARA;NDUFS1;ERN1;CASP8;IL6;NDUFV3;NDUFA8;NDUFAB1;UQCRH
Amyotrophic lateral sclerosis (ALS)GPX1;TP53;CCS;TOMM40L;TNF;NEFM;GRIA1;TOMM40;MAP2K3

MAP3K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K5 itself. We selected most functions MAP3K5 had, and list some proteins which have the same functions with MAP3K5. You can find most of the proteins on our site.

Function Related Protein
MAP kinase kinase kinase activityBRAF;MAP3K12;MAP3K3;STK4;MAP3K13;TAOK3;MAP3K6;ALPK2;EGFR
magnesium ion bindingMAST4;EYA2;ITPK1A;HPGDS;MAST2;PDXP;ZNF143B;NUDT16;PPM1A
protein bindingTNNI3;ZC3H15;RYBP;CD97;CUL1;RNF11;CTPS2;FAM193B;KLF11
protein homodimerization activityCALCOCO2;SNX6;NLGN4X;DMRTC2;GPD1L;RBM11;VWF;TCF12;PEX11B
protein kinase bindingPPME1;PGAM1;AP2A2;MSN;TEX14;BCAR1;TBL2;PRKCZ;RCC2
protein phosphatase bindingFGF19;RPA3;TRP53;ERBB2;AP3B1;DRD1A;SHOC2;JUP;PPP6R3

MAP3K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K5.


Izykowska, K; Zawada, M; et al. Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. EUROPEAN JOURNAL OF HAEMATOLOGY 93:143-149(2014).
Cole, JB; Waurich, B; et al. A genome-wide association study of calf birth weight in Holstein cattle using single nucleotide polymorphisms and phenotypes predicted from auxiliary traits. JOURNAL OF DAIRY SCIENCE 97:3156-3172(2014).
  • Q&As
  • Reviews

Q&As (5)

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What other diseases or conditions involve MAP3K5? 12/19/2022

MAP3K5 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions.

How is MAP3K5 protein implicated in cancer? 08/05/2022

Aberrant regulation of MAP3K5 has been associated with cancer development, as it can influence cell survival and death pathways.

Can MAP3K5 be used as a biomarker for certain diseases? 09/09/2021

MAP3K5 expression levels and activity may serve as biomarkers for specific diseases, providing valuable information for diagnosis and prognosis.

Are there any clinical applications of MAP3K5 in cancer treatment? 02/02/2018

Research suggests that targeting MAP3K5 could have therapeutic implications in cancer treatment, potentially through the modulation of apoptosis in cancer cells.

Are there ongoing clinical trials involving MAP3K5 inhibitors? 10/24/2017

Investigational studies and clinical trials are underway to explore the efficacy of MAP3K5 inhibitors in different disease contexts, including cancer.

Customer Reviews (3)

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    The MAP3K5 protein has proven to be invaluable in protein electron microscopy structure analysis.


      Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.


        The MAP3K5 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

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