MAP3K5 Protein


Home / Products / MAP3K5


Official Full Name mitogen-activated protein kinase kinase kinase 5
Background Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Synonyms MAP3K5; mitogen-activated protein kinase kinase kinase 5; ASK1; MEKK5; MAPKKK5; apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; OTTHUMP00000017275; MAP/ERK kinase kinase 5
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K5-578H Active Recombinant Human MAP3K5, GST-tagged Sf9 Insect Cell GST Inquiry
    Human MAP3K5-11H Recombinant Human MAP3K5 protein, His-tagged E.coli His Inquiry
    Human MAP3K5-1260H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 5, GST-tagged Insect Cell GST Inquiry
    Human MAP3K5-20H Recombinant Human MAP3K5 protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human MAP3K5-245H Recombinant Human MAP3K5, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human MAP3K5-26518TH Recombinant Human MAP3K5 N/A Inquiry
    Human MAP3K5-63H Recombinant Human MAP3K5 protein, Flag-tagged, Biotinylated Insect Cell Flag Inquiry
    Mouse ASK1-3585M Recombinant Mouse ASK1, His-tagged, T7 tagged E.coli His/T7
    Mouse MAP3K5-9515M Recombinant Mouse MAP3K5 Protein Mammalian Cell His Inquiry
    Zebrafish MAP3K5-7528Z Recombinant Zebrafish MAP3K5 Mammalian Cell His Inquiry
    Human MAP3K5-4504HCL Recombinant Human MAP3K5 293 Cell Lysate HEK293 N/A Inquiry
    Human MAP3K5-361HFL Recombinant Full Length Human MAP3K5 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Mouse Map3k5-3931M Recombinant Mouse Map3k5 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    MAP3K5 involved in several pathways and played different roles in them. We selected most pathways MAP3K5 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RAF1B; TGFB1; HSP70; CACNA1BA; FGF1; PLA2G4D; Fasl; CACNB3A; MAP2K2; MAP3K4
    Sphingolipid signaling pathway FCER1G; GNAI1; LASS4; S1PR4; PLCB1; MAPK1; S1PR2; PPP2R2D; PPP2R5C; TRAF2
    Protein processing in endoplasmic reticulum DNAJB1A; HSPA4L; CANX; UBE2G1A; SEC13; ERO1L; MAP3K5; HSPA1A; SKP1; HSP90AA1
    TNF signaling pathway PIK3R5; VCAM1; IL18R1; FADD; CXCL5; MAP2K1; CASP7; TAB2; RPS6KA5; RPS6KA4
    Neurotrophin signaling pathway RAC1; NFKBIA; BCL2; GRB2; NTRK2; MAPK1; PIK3R5; NFKBIB; TP73; PIK3CD
    Non-alcoholic fatty liver disease (NAFLD) FASLG; NDUFS2; NDUFV2; SDHC; UQCRC1; NDUFS8; MAPK8; Fasl; MAP3K5; MAPK10
    Amyotrophic lateral sclerosis (ALS) PRPH; MAPK11; NEFH; GPX1; GRIA2; MAP2K6; RAC1; TNFRSF1A; GRIN2C; PPP3R2

    MAP3K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K5 itself. We selected most functions MAP3K5 had, and list some proteins which have the same functions with MAP3K5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RTEL1; NADK2; P2RX1; HK1; MYLK3; ATP13A1; PRKG1A; GAK; PFTK1; FES
    MAP kinase kinase kinase activity ZAK; MAP3K14; MAP3K1; MAP3K6; MOS; MAP3K8; MAP3K3; MAP3K4; KIAA1804; TAOK1
    magnesium ion binding ERN1; PPM1B; PAPOLA; ILVBL; WEE2; GSS; NUDT16; COMTB; TESC; ZAK
    protein binding NAA50; ENO1; ABCD2; ERP44; SOX4; BCL2L15; MXD4; GPS1; CD24; ITSN2
    protein homodimerization activity KLRB1B; NR6A1B; KCNE2; FZD1; ALDH5A1; PRMT8; OXA1L; TENM3; EIF2AK3; MTMR2
    protein kinase activity CSNK2A2A; EPHB4A; SRPK1A; NEK1; LIMK1; CDK17; SGK3; EK1; PTK2; RPS6KA3B
    protein kinase binding TENC1; PTPN23; FOXO3; CCND1; CDKN2B; MAPK8IP2; CACNB3; PTPN1; PTEN; HSPB1
    protein phosphatase binding ANAPC5; FLT4; PIK3R2; DLG4; HSP90B1; ANAPC4; ITGA1; CSF1R; CDKN1B; JUPA

    MAP3K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K5.

    DAXX; YWHAZ; N/A; ZNF622

    Izykowska, K; Zawada, M; et al. Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. EUROPEAN JOURNAL OF HAEMATOLOGY 93:143-149(2014).
    Cole, JB; Waurich, B; et al. A genome-wide association study of calf birth weight in Holstein cattle using single nucleotide polymorphisms and phenotypes predicted from auxiliary traits. JOURNAL OF DAIRY SCIENCE 97:3156-3172(2014).

    Q&As (0)

    Ask a Question for All MAP3K5 Products

    Required fields are marked with *

    • Verification Code

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2023 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy