MAP3K5 Protein


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Official Full Name mitogen-activated protein kinase kinase kinase 5
Background Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Synonyms MAP3K5; mitogen-activated protein kinase kinase kinase 5; ASK1; MEKK5; MAPKKK5; apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; OTTHUMP00000017275; MAP/ERK kinase kinase 5
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K5-578H Recombinant Human MAP3K5, GST-tagged Sf9 Insect Cell GST
    Human MAP3K5-11H Recombinant Human MAP3K5 protein, His-tagged E.coli His
    Human MAP3K5-1260H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 5, GST-tagged Insect Cell GST
    Human MAP3K5-20H Recombinant Human MAP3K5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP3K5-245H Recombinant Human MAP3K5, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP3K5-26518TH Recombinant Human MAP3K5 N/A
    Human MAP3K5-63H Recombinant Human MAP3K5 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse ASK1-3585M Recombinant Mouse ASK1, His-tagged, T7 tagged E.coli His/T7
    Mouse MAP3K5-9515M Recombinant Mouse MAP3K5 Protein Mammalian Cell His
    Zebrafish MAP3K5-7528Z Recombinant Zebrafish MAP3K5 Mammalian Cell His
    Human MAP3K5-4504HCL Recombinant Human MAP3K5 293 Cell Lysate HEK293 N/A
    Mouse Map3k5-3931M Recombinant Mouse Map3k5 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP3K5 involved in several pathways and played different roles in them. We selected most pathways MAP3K5 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway ELK4; BDNF; MAP4K4; DUSP3; RAC1B; RPS6KAL; FGF1B; TGFBR1A; MAPK14B; PTPN7
    Sphingolipid signaling pathway CERS2; PPP2R1A; GNAI2; ASAH2; FYN; PPP2R5B; BCL2; PIK3R1; NFKB1; PPP2R1B
    Protein processing in endoplasmic reticulum UBE2G1B; ERN1; BCAP31; CAPN2B; UBE2D2; STT3A; SEC31B; ERO1L; DNAJC5B; RAD23B
    TNF signaling pathway ITCH; MAPK10; TAB2; SELE; CCL2; MMP3; PIK3CA; BIRC2; CASP7; PIK3CB
    Neurotrophin signaling pathway SH2B3; YWHAE; AKT2; NTRK2; MAPK7; PIK3R2; RPS6KA6; TP73; SHC4; PIK3R3
    Non-alcoholic fatty liver disease (NAFLD) UQCRQ; PRKAG3; NDUFA4; PPARA; NDUFA10; NR1H3; SDHC; ITCH; MAPK10; AKT2
    Amyotrophic lateral sclerosis (ALS) TNFRSF1A; NOS1; GRIN2D; GRIA1; DERL1; TRP53; BID; NEFH; MAPK13; PRPH

    MAP3K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K5 itself. We selected most functions MAP3K5 had, and list some proteins which have the same functions with MAP3K5. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase activity KIAA1804; STK3; MAP3K2; MAP3K13; MAP3K15; ALPK2; MAP3K1; MAP3K12; MAP3K5; MAP3K3
    magnesium ion binding DXO; GLUL; FAN1; CDC42BPB; PKM; TSSK6; PGM3; RPS6KA5; IDH3A; NUDT16
    protein binding NUDT18; TMSB4Y; SNTA1; PSTPIP1; INSIG1; CRABP2; CLSTN2; NCF1; MED15; FOXC1
    protein homodimerization activity SPPL2B; SPATA24; BNIP3; UGT1A4; MUC13; APOA4; CHMP3; PDCD6; DGAT2; USF1
    protein kinase activity MAPK8B; Fert2; AURKC; ANKK1; RPS6KAL; RPS6KB1; RAF1B; SGK3; PRKCBA; MOK
    protein kinase binding HNRNPA0; TRPV4; MAPK8IP2; FZD5; HDAC7; CCNL1B; MSN; EEF1A2; PTPRC; ADIPOR1
    protein phosphatase binding ROS1; MET; Itga10&Itgb1; PPP6R1; TRAF2; ITGA1; JAK1; VCP; SNX3; PPP6R3

    MAP3K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K5.

    DAXX; YWHAZ; N/A; ZNF622

    Izykowska, K; Zawada, M; et al. Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. EUROPEAN JOURNAL OF HAEMATOLOGY 93:143-149(2014).
    Cole, JB; Waurich, B; et al. A genome-wide association study of calf birth weight in Holstein cattle using single nucleotide polymorphisms and phenotypes predicted from auxiliary traits. JOURNAL OF DAIRY SCIENCE 97:3156-3172(2014).

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