Recombinant Human MAP3K5, GST-tagged, Active
| Cat.No. : | MAP3K5-245H |
| Product Overview : | Recombinant human ASK1(649-946) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 60 kDa. |
- Specification
- Gene Information
- Related Products
| Cat. No. : | MAP3K5-245H |
| Description : | ASK1, also known as MAPKKK5, activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with tumor necrosis factor-alpha. ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation. |
| Source : | Sf9 insect cells using baculovirus. |
| Sequence : | Full-length. |
| Applications : | Kinase Assay, Western Blot. |
| Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | MAP3K5 mitogen-activated protein kinase kinase kinase 5 [ Homo sapiens ] |
| Synonyms : | mitogen-activated protein kinase kinase kinase 5; ASK1; MEKK5; MAPKKK5; MAP3K5; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; apoptosis signal regulating kinase 1; ASK-1; EC 2.7.11.25; OTTHUMP00000017275; Apoptosis signal-regulating kinase 1; MEK kinase 5 |
| Gene ID : | 4217 |
| mRNA Refseq : | NM_005923 |
| Protein Refseq : | NP_005914 |
| MIM : | 602448 |
| UniProt ID : | Q99683 |
| Chromosome Location : | 6q22.33 |
| Pathway : | Amyotrophic lateral sclerosis (ALS); MAPK signaling pathway; Neurotrophin signaling pathway |
| Function : | MAP kinase kinase kinase activity; protein serine/threonine kinase activity; protein homodimerization activity; ATP binding; caspase activator activity; magnesium ion binding; nucleotide binding; transferase activity |
Products Types
| ◆ Recombinant Protein | ||
| MAP3K5-1093H | Recombinant Human MAP3K5 Protein (M649-K946), GST/His tagged | +Inquiry |
| MAP3K5-5333M | Recombinant Mouse MAP3K5 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Map3k5-3931M | Recombinant Mouse Map3k5 Protein, Myc/DDK-tagged | +Inquiry |
| MAP3K5-1359H | Recombinant Human MAP3K5 Protein, His (Fc)-Avi-tagged | +Inquiry |
| MAP3K5-1092H | Recombinant Human MAP3K5 Protein (M649-K946), His tagged | +Inquiry |
| ◆ Lysates | ||
| MAP3K5-4504HCL | Recombinant Human MAP3K5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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