Recombinant Human MAP3K5 protein, Flag-tagged, Biotinylated
Cat.No. : | MAP3K5-63H |
Product Overview : | Recombinant Human MAP3K5, catalytic domain [654-971 amino acids of accession number NP_005914.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated. |
- Specification
- Gene Information
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Source : | Insect cell |
Species : | Human |
Tag : | Flag |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Molecular Mass : | 39 kDa |
Purity : | >90% as determined by SDS-PAGE and CBB staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | MAP3K5 mitogen-activated protein kinase kinase kinase 5 [ Homo sapiens ] |
Official Symbol : | MAP3K5 |
Synonyms : | MAP3K5; MEKK5; apoptosis signal regulating kinase 1; ASK1; MAPKKK5; ASK-1; MEKK 5; MEK kinase 5; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5 |
Gene ID : | 4217 |
mRNA Refseq : | NM_005923 |
Protein Refseq : | NP_005914 |
MIM : | 602448 |
UniProt ID : | Q99683 |
Chromosome Location : | 6q22.33 |
Pathway : | Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Class I PI3K signaling events mediated by Akt, organism-specific biosystem; HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase kinase activity; cysteine-type endopeptidase activator activity involved in apoptotic process; magnesium ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMAP3K5 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions.
Aberrant regulation of MAP3K5 has been associated with cancer development, as it can influence cell survival and death pathways.
MAP3K5 expression levels and activity may serve as biomarkers for specific diseases, providing valuable information for diagnosis and prognosis.
Research suggests that targeting MAP3K5 could have therapeutic implications in cancer treatment, potentially through the modulation of apoptosis in cancer cells.
Investigational studies and clinical trials are underway to explore the efficacy of MAP3K5 inhibitors in different disease contexts, including cancer.
Customer Reviews (3)
Write a reviewThe MAP3K5 protein has proven to be invaluable in protein electron microscopy structure analysis.
Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.
The MAP3K5 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
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