MAP4K5
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Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5
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Background
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. -
Synonyms
MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; GCKR; germinal center kinase related; KHS; KHS1; MEKKK 5; MEK kinase kinase 5; germinal center kinase-related; MAPK/ERK kinase kinase kinase 5; kinase homologous to SPS1/STE20; MAPKKKK5;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAP4K5 Related Articles
MAP4K5 involved in several pathways and played different roles in them. We selected most pathways MAP4K5 participated on our site, such as Insulin Signaling, TNF receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | STXBP3A;STXBP4;MAP3K9;GSK3AB;STXBP3;KIF5B;GRB14;RHOJ;RRAD |
| TNF receptor signaling pathway | RFFL;NRK;TNIK;MAP4K5 |
MAP4K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K5 itself. We selected most functions MAP4K5 had, and list some proteins which have the same functions with MAP4K5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | IDE;NVL;MARK4;DDX59;DCLK1;ILK;SWAP70;LIMK1;PEX6 |
| MAP kinase kinase kinase kinase activity | MAP4K5;MAP4K6;ALPK2;MAP4K2;MAP4K1;MAP4K3 |
| protein binding | SHPRH;LOXL2;USH1C;NOTCH1;DNAJC19;ASUN;MPZL2B;GAL;SMAD7 |
| protein kinase activity | FGFR1B;PDGFRA;CDK8;MAPK8A;BMPR2A;BMPR1BA;PKN2;STK35L;CCL3 |
| protein serine/threonine kinase activity | GRK7B;CDK15;TRIO;MAPK12B;NEK8;MAPK8A;TTN;SMOK3B;ERN2 |
MAP4K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K5.
GRB2; CRK; abl-tide; FYN; NCK1; CRKL; HCK; SETDB1; ZNF440; COPS5; linkable pd173955 analogue; bosutinib
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