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  • Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 5

  • Overview

    This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
  • Synonyms

    MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; GCKR; germinal center kinase related; KHS; KHS1; MEKKK 5; MEK kinase kinase 5; germinal center kinase-related; MAPK/ERK kinase kinase kinase 5; kinase homologous to SPS1/STE20; MAPKKKK5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP4K5-102HFL Active Recombinant Full Length Human MAP4K5 Protein, N-GST-tagged Sf21 GST Full Length
Human MAP4K5-375H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, GST-tagged Insect Cell GST
Human MAP4K5-947H Recombinant Human MAP4K5 protein, His&GST-tagged Insect Cells His/GST Met1-Tyr846
Human MAP4K5-341H Recombinant Human MAP4K5, GST-tagged, Active Sf9 Insect Cell GST
Human MAP4K5-1536H Recombinant Human MAP4K5 protein, His & T7-tagged E.coli His/T7 Thr613~His842 (Accession # Q9Y4K4)
Human MAP4K5-631HCL Recombinant Human MAP4K5 cell lysate Insect Cell N/A
Human MAP4K5-3979H Recombinant Human MAP4K5 protein, His-tagged E.coli His 5-274 aa
Human MAP4K5-388H Recombinant Human MAP4K5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP4K5-2472H Recombinant Human MAP4K5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP4K5-1433HFL Recombinant Full Length Human MAP4K5 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP4K5-1360H Recombinant Human MAP4K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP4K5-3965H Recombinant Human MAP4K5 Protein (Thr613-His842), N-His tagged E.coli N-His Thr613-His842
Human MAP4K5-1360H-B Recombinant Human MAP4K5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Map4k5-1537M Recombinant Mouse Map4k5 protein, His & T7-tagged E.coli His/T7 Ala9~Ser231 (Accession # Q8BPM2)
Zebrafish MAP4K5-10282Z Recombinant Zebrafish MAP4K5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP4K5 Related Articles

MAP4K5 involved in several pathways and played different roles in them. We selected most pathways MAP4K5 participated on our site, such as Insulin Signaling, TNF receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TNF receptor signaling pathwayMAP4K5;TNIK;RFFL;NRK

MAP4K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K5 itself. We selected most functions MAP4K5 had, and list some proteins which have the same functions with MAP4K5. You can find most of the proteins on our site.

Function Related Protein
MAP kinase kinase kinase kinase activityMAP4K1;MAP4K5;MAP4K3;MAP4K6;MAP4K2;ALPK2
protein serine/threonine kinase activityMAST2;CLK1;MAP2K5;DAPK3;CAMKK1B;STK10;MAP4K5;DYRK3;PRKCHA

MAP4K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K5.

GRB2; CRK; abl-tide; FYN; NCK1; CRKL; HCK; SETDB1; ZNF440; COPS5; linkable pd173955 analogue; bosutinib

Nishi, H; Maeda, N; et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 748:133-142(2015).
Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
  • Q&As
  • Reviews

Q&As (5)

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Are there any MAP4K5-targeted therapies currently available? 04/01/2022

As of now, MAP4K5-targeted therapies are primarily in the experimental stage, and none have been approved for clinical use.

How does MAP4K5 influence immune responses? 07/23/2021

MAP4K5 is involved in modulating immune responses, and its dysregulation may contribute to autoimmune disorders.

How is MAP4K5 linked to neurodegenerative disorders? 01/26/2021

MAP4K5 has been implicated in neurodegenerative disorders, and its study may provide insights into the underlying mechanisms of these conditions.

Is MAP4K5 involved in drug resistance in cancer treatment? 07/12/2019

There is evidence suggesting that MAP4K5 may contribute to drug resistance in certain cancer types, making it an important target for overcoming resistance mechanisms.

Can MAP4K5 inhibition be personalized for different patients? 10/15/2017

Personalized medicine approaches are being explored to tailor MAP4K5-targeted therapies based on individual patient characteristics and disease profiles.

Customer Reviews (3)

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    Its reliability and applicability make it an invaluable tool for investigating MAP4K5 protein's expression, function, and structural characteristics.


      Manufacturers can enhance the research process by providing high-quality MAP4K5 protein, technical support, customization options, and potentially collaborative opportunities.


        The high-quality MAP4K5 protein available from manufacturers ensures consistent and reproducible results in WB experiments, making it an essential tool for researchers studying ANO2-related pathways and biological processes.

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