MAP4K5 Protein


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Official Full Name mitogen-activated protein kinase kinase kinase kinase 5
Background This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Synonyms MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; GCKR; germinal center kinase related; KHS; KHS1; MEKKK 5; MEK kinase kinase 5; germinal center kinase-related; MAPK/ERK kinase kinase kinase 5; kinase homologous to SPS1/STE20; MAPKKKK5;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP4K5-1536H Recombinant Human MAP4K5 protein, His & T7-tagged E.coli His/T7 Inquiry
    Human MAP4K5-341H Recombinant Human MAP4K5, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human MAP4K5-375H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, GST-tagged Insect Cell GST Inquiry
    Human MAP4K5-947H Recombinant Human MAP4K5, His & GST tagged Insect Cell His/GST
    Mouse Map4k5-1537M Recombinant Mouse Map4k5 protein, His & T7-tagged E.coli His/T7 Inquiry
    Zebrafish MAP4K5-10282Z Recombinant Zebrafish MAP4K5 Mammalian Cell His Inquiry
    Human MAP4K5-631HCL Recombinant Human MAP4K5 cell lysate Insect Cell N/A Inquiry
    Human MAP4K5-1360H Recombinant Human MAP4K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP4K5-1433HFL Recombinant Full Length Human MAP4K5 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human MAP4K5-3979H Recombinant Human MAP4K5 protein, His-tagged E.coli His Inquiry
    Human MAP4K5-2472H Recombinant Human MAP4K5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human MAP4K5-388H Recombinant Human MAP4K5 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry

    MAP4K5 involved in several pathways and played different roles in them. We selected most pathways MAP4K5 participated on our site, such as Insulin Signaling, TNF receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin Signaling MAP3K9; FLOT1; GRB10; EHD1; SNAP25A; GSK3AB; MAP4K1; CAP1; INPP4AA; MAP3K10
    TNF receptor signaling pathway MAP4K5; TNIK; RFFL; NRK

    MAP4K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K5 itself. We selected most functions MAP4K5 had, and list some proteins which have the same functions with MAP4K5. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase kinase activity MAP4K3; MAP4K2; MAP4K6; MAP4K1; ALPK2; MAP4K5
    protein binding LCOR; CAPNS1; SREK1IP1; CDC5L; DHX32; RBM11; NEDD8; SEMA6A; MYH7; COLQ
    protein kinase activity STK24; PDGFRA; PKN3; CAMK1DB; EK1; MAP3K11; ROCK1; DCLK2; SOX9; PAK4
    protein serine/threonine kinase activity CAMK1GB; PAK6; TAOK1; CSNK2A1; STK16; DMPK; PKN1B; MAP2K4; MAPK12; KALRN

    MAP4K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K5.

    GRB2; CRK; abl-tide; FYN; NCK1; CRKL; HCK; SETDB1; ZNF440; COPS5; linkable pd173955 analogue; bosutinib

    Nishi, H; Maeda, N; et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 748:133-142(2015).
    Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).

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