Recombinant Mouse Map4k5 protein, His & T7-tagged

• Cat.No.: Map4k5-1537M
• Product Overview: Recombinant Mouse Map4k5 aa. (Ala9~Ser231 (Accession # Q8BPM2)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 28.7kDa.
• Protein length: Ala9~Ser231 (Accession # Q8BPM2)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method).
• Purity: >95%
• Characteristic: The isoelectric point is 6.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Mus musculus (house mouse) ]
• Official Symbol: Map4k5
• Synonyms: KHS; GCKR; MAPKKKK5; 4432415E19Rik; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5; map4k5; mitogen-activated protein kinase kinase kinase kinase 5
• Gene ID: 399510
• mRNA Refseq: NM_201519.2
• Protein Refseq: NP_958927.2
• UniProt ID: Q8BPM2

Reviews

01/24/2023

Its reliability and applicability make it an invaluable tool for investigating MAP4K5 protein's expression, function, and structural characteristics.

01/26/2019

Manufacturers can enhance the research process by providing high-quality MAP4K5 protein, technical support, customization options, and potentially collaborative opportunities.

01/20/2019

The high-quality MAP4K5 protein available from manufacturers ensures consistent and reproducible results in WB experiments, making it an essential tool for researchers studying ANO2-related pathways and biological processes.

Q&As

Are there any MAP4K5-targeted therapies currently available?

As of now, MAP4K5-targeted therapies are primarily in the experimental stage, and none have been approved for clinical use.

How does MAP4K5 influence immune responses?

MAP4K5 is involved in modulating immune responses, and its dysregulation may contribute to autoimmune disorders.

How is MAP4K5 linked to neurodegenerative disorders?

MAP4K5 has been implicated in neurodegenerative disorders, and its study may provide insights into the underlying mechanisms of these conditions.

Is MAP4K5 involved in drug resistance in cancer treatment?

There is evidence suggesting that MAP4K5 may contribute to drug resistance in certain cancer types, making it an important target for overcoming resistance mechanisms.

Can MAP4K5 inhibition be personalized for different patients?

Personalized medicine approaches are being explored to tailor MAP4K5-targeted therapies based on individual patient characteristics and disease profiles.