mapk12
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  • Official Full Name
  • mitogen-activated protein kinase 12
  • Background
  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
  • Synonyms
  • MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitoge
Cat.#:MAPK12-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12 Protein, His-tagged
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Cat.#:MAPK12-264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, Gly & Pro tagged
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Cat.#:MAPK12-279HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, His-GST tagged
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Cat.#:MAPK12-27HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12 protein, GST-tagged
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Cat.#:MAPK12-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK12, His-tagged
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Cat.#:MAPK12-31377THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK12
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Cat.#:MAPK12-31378THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12, His-tagged
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Cat.#:MAPK12-375HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12, GST-tagged, Active
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Cat.#:MAPK12-738HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 12
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Cat.#:MAPK12-9528MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK12 Protein
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Cat.#:MAPK12-3572RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK12 Protein
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Cat.#:MAPK12-1264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-1343HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12 cell lysate
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Involved Pathway

MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGFR3; GNA12; RPS6KA3; NFKB2; MAP4K3; FGF4; MYCB; ACVR1C; STK4; FGFR2
Rap signaling pathway
KLK1B4; PIK3R2; RAP1GAP; FPR1; LCP2; PARD3; ITGB2; FGF2; FGF21; PLCG1
FoxO signaling pathway
MAPK9; PLK1; GADD45AA; BCL6A; GADD45G; FOXO4; SMAD3A; STAT3; KLF2A; HOMER1
Sphingolipid signaling pathway
CERS5; SPHK2; PPP2R1A; AKT2; LASS4; AKT1; BID; LASS1; SPTLC1; PIK3CD
Oocyte meiosis
PRKACB; RPS6KA3; PPP1CBL; ADCY1A; ANAPC7; PTTG1; MAD2L1; RPS6KA2; YWHABL; PRKACG
Adrenergic signaling in cardiomyocytes
PPP2R5D; TNNT2A; PPP2R5C; MYL3; ATP2B1; ACTC1A; ADRA1D; ATP1A2; CALM2A; PRKACAB
VEGF signaling pathway
MAPK12; PPP3CCB; NOS3; RAC1B; SH2D2A; PTK2AB; SRC; RAC1A; MAPK14A; CDC42L2
Osteoclast differentiation
MAPK12; FHL2; LCK; PIK3CB; TNFRSF1A; TREM2; IL1R1; MAP2K7; IKBKB; NFATC2
Signaling pathways regulating pluripotency of stem cells
GSK3B; ID1; HNF1A; WNT8B; WNT2; SMAD3; AKT2; ISL1; FGFR1; AKT1
Platelet activation
PTGIR; MAPK1; ITGA2; GNAS; PLA2G4F; VAMP8; MYLK2; P2RY1; GNAI1; SRC
Toll-like receptor signaling pathway
TLR2-1; AKT3A; MAPK9; CD40; MAPK8B; IFNAR2; IRF3; PIK3R3; IL1B; IFNA4
NOD-like receptor signaling pathway
NAIP1; IKBKG; IL8L1; CXCL8B.3; CCL5; HSP90AA1.2; LOC100033925; CCL2; CXCL2; SUGT1
RIG-I-like receptor signaling pathway
IL12A; NFKBIA; IFNA7; MAPK13; RNF125; MAP3K1; DDX58; OTUD5A; AZI2; IFIH1
T cell receptor signaling pathway
PPP3R1; CD247; CD28; CARD11; TNF; PTPRC; BCL10; CD3E; CD3D; KRAS; MAPK1
Fc epsilon RI signaling pathway
GRB2; MAP2K1; RAC2; MS4A2; IL4; RAF1; LCP2; RAC3; PDPK1; GAB2
TNF signaling pathway
CXCL10; TRAF3; SELE; PIK3CB; CREB3L1; CFLAR; TAB2; PIK3CG; PIK3CA; PIK3CD
Leukocyte transendothelial migration
MSN; GNAI3; CLDN10; ITGB2; ESAM; Itgam&Itgb2; CLDN15; CDC42; CLDN14; CLDN22
Neurotrophin signaling pathway
BAD; CALML3; TRAF6; PIK3CG; HRAS; RHOA; RPS6KA3; CALM1; CALM2; NRAS
Retrograde endocannabinoid signaling
GNAI3; GNAI1; GNGT1; PLCB2; GNG12; GNG4; GRM1; MAPK9; PRKACG; ITPR3
Dopaminergic synapse
CREB3L4; PPP2CB; GNAI3; ARRB2; PPP2R5E; PPP2R5B; AKT2; GNAQ; PLCB3; CREB3L3
Inflammatory mediator regulation of TRP channels
PLCB2; MAPK11; BDKRB1; Adcy4; PRKCQ; CAMK2G; ACCN5; CYP2C55; PLA2G4A; HRH1
GnRH signaling pathway
MAP2K2; GNAQ; PRKACB; CAMK2B1; GRB2B; MAPK3; NRAS; MAP2K6; PTK2BB; GNAS
Progesterone-mediated oocyte maturation
CDC27; ANAPC4; MAPK11; ADCY1A; MAPK8; BUB1; CCNB1; PIK3R3B; GNAI3; CPEB1
Prolactin signaling pathway
SHC1; INS; GSK3B; MAPK3; RAF1; SOCS6; FOXO3; SIRPA; SOCS3; MAP2K1
Amyotrophic lateral sclerosis (ALS)
TP53; CCS; CYCS; PRPH; GRIN2D; DERL1; MAPK12; BID; SOD1; CASP9
Epithelial cell signaling in Helicobacter pylori infection
MAPK10; MAP3K14; ATP6V0E1; MAPK11; ATP6V0D1; CXCR1; ATP6V1G1; IKBKB; ATP6V1H; ADAM17
Shigellosis
ACTB; VCL; ATG5; IL-8; IKBKG; MAPK12; MAPK1; NFKBIA; HCLS1; MAPK3
Salmonella infection
WASF1; WASLB; MAPK8; RILP; PFN4; ARPC5LA; RHOGC; CCL4L2; ACTB1; RAC1
Pertussis
Casp3; MAPK12; CALML3; TLR4; Il23a; IRAK4; ITGB1; IL12B; ITGB2L; IL12A
Leishmaniasis
MYD88; CR1; HLA-DPA1; ITGB2; HLA-DQA2; HLA-DRB1; IFNGR1; ITGB1; C3; FCGR3A
Chagas disease (American trypanosomiasis)
PIK3CD; TGFBR2; TGFBR1; C1QC; SMAD2; FAS; C1QA; MAPK13; PIK3CB; C1QB
Toxoplasmosis
BIRC8; PIK3R3; TLR2; LAMA1; BCL2; TYK2; PIK3CD; LAMB4; MAPK9; ITGA6
Tuberculosis
SYK; Casp3; Cd209g; RAF1; ITGB2L; HLA-DMA; HLA-DPB1; HLA-DQA1; PPP3CC; HLA-DQB1
Hepatitis C
CLDN14; RIPK1; TRAF6; IFNA5; CLDN17; CLDN8; IFNA17; EIF2AK2; PIAS1; PIK3CD
Influenza A
OAS1B; TMPRSS2; PIK3CG; OAS1A; KPNA1; IRF7; IFNA4; TNFRSF10D; H2-AB1; IFNA21
Epstein-Barr virus infection
FGR; TRAF5; MAPK13; ENTPD8; POLR3H; EIF2AK2; MAP3K14; HLA-DPB1; BCL2; EIF2AK4
Proteoglycans in cancer
FZD1; ITGA2; ITGB5; PLAUR; NANOG; MMP9; MET; MAPK3; PTK2; PIK3CB

Protein Function

MAPK12 has several biochemical functions, for example, ATP binding, MAP kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACVR2B; DAPK2; FARSB; NLRC3; EPHA4A; PGS1; DHX32A; Abcb1b; ACACB; NOLC1
Function MAP kinase activity
Related Protein MAPK12B; MAPK11; MAPK8B; MAPK14B; NLK2; MAPK13; MAPK15; MAPK7; MAPK12; NLK
Function magnesium ion binding
Related Protein NT5C1A; CLYBL; NLK; DXO; FOXK2; SRPK1; PPM1NB; TSSK4; HMGCL; MAP3K6
Function protein binding
Related Protein CUTC; C19orf10; MKKS; CRYAB; C1orf182; RTN1; ISG20L2; POMGNT1; CNTNAP2; H2AFX
Function protein serine/threonine kinase activity
Related Protein C9orf96; SIK2; PIK3R4; PDPK1; ULK2; PHKG1A; MAP4K1; SIK3; PRKACAA; SBK3

Interacting Protein

MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.
SIAH1; saicar; PKM; PTPN4; SRPK1; DUSP1; DLG1; PKN1; TERF1; GTF2I; PDGFRL; MAPK1; PRPF4B; MAPK15