MAPK12

  • Official Full Name

    mitogen-activated protein kinase 12

  • Overview

    Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
  • Synonyms

    MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitoge;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK12-9248HF Active Recombinant Full Length Human MAPK12 Protein, GST-tagged E.coli GST 1-367
Human MAPK12-31377TH Recombinant Human MAPK12 N/A
Human MAPK12-169H Recombinant Human MAPK12 Protein, His-tagged E.coli His
Human MAPK12-375H Recombinant Human MAPK12, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK12-264H Recombinant Human MAPK12, Gly & Pro tagged Insect Cell His
Human MAPK12-738H Recombinant Human Mitogen-activated Protein Kinase 12 E.coli N/A
Human MAPK12-30H Recombinant human biotinylated MAPK12, His-tagged E.coli His
Human MAPK12-1343H Recombinant Human Mitogen-Activated Protein Kinase 12, His-tagged E.coli His 1-367aa
Human MAPK12-279H Recombinant Human MAPK12, His-GST tagged Insect Cell His
Human MAPK12-1264H Recombinant Human Mitogen-Activated Protein Kinase 12, His-tagged Insect Cell His
Human MAPK12-27H Recombinant Human MAPK12 protein, GST-tagged Insect Cell GST
Human MAPK12-001HCL Recombinant Human MAPK12 cell lysate Insect Cell N/A
Human MAPK12-1086H Recombinant Human MAPK12 Protein (S2-L367), Tag Free Insect Cell No tag S2-L367
Human MAPK12-1340H Recombinant Human MAPK12 protein, His-tagged E.coli His 216-349 aa
Human MAPK12-5076H Recombinant Human MAPK12 Protein (Tyr27-Phe311), N-His tagged E.coli N-His Tyr27-Phe311
Human MAPK12-1087H Recombinant Human MAPK12 Protein (S2-L367), GST tagged Insect Cell GST S2-L367
Human MAPK12-3014H Recombinant Human MAPK12 protein, GST-tagged E.coli GST Met216-Leu349
Human MAPK12-0285H Recombinant Human MAPK12 protein, His&GST-tagged Insect Cells His/GST Met1-Leu367
Mouse MAPK12-9528M Recombinant Mouse MAPK12 Protein Mammalian Cell His
Mouse MAPK12-5345M Recombinant Mouse MAPK12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAPK12-5345M-B Recombinant Mouse MAPK12 Protein Pre-coupled Magnetic Beads HEK293
Rat MAPK12-3572R Recombinant Rat MAPK12 Protein Mammalian Cell His
Rat MAPK12-3228R Recombinant Rat MAPK12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAPK12-3228R-B Recombinant Rat MAPK12 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAPK12 Related Signal Pathway

MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayGNG12;MAP4K2;MINK1;CASP3B;MAP4K1;MKNK1;PRKCG;FGF20;MAPK14A
Rap signaling pathwayCDH1;APBB1IP;ITGB3;HRAS;RAPGEF1;NGFR;FGF20;CDC42;GNAS
FoxO signaling pathwayPRKAB1B;GADD45B;SMAD3A;HRASA;GABARAPL1;PLK3;PRKAA1;GRM1;MAPK14A
Sphingolipid signaling pathwayTRAF2;GNAI1;FCER1A;DEGS2;KRAS;PIK3R1;MAPK12;NRAS;SMPD2
Oocyte meiosisITPR3;SPDYA;ESPL1;YWHAQB;CALM3A;ANAPC13;PPP2CB;SLKA;CUL1B
Adrenergic signaling in cardiomyocytesPRKACAB;CALM;AKT2L;PIK3CB;GNAIA;PPP2R3A;CREB3L3A;ATP1A2A;ATP1A1B
VEGF signaling pathwayPPP3CCB;PTGS2B;MAPKAPK2A;RAF1B;CDC42L2;PXNA;HRAS;SPHK1;MAPK11
Osteoclast differentiationMAPK3;TYK2;IL1R1;IKBKB;AKT2;AKT1;MAPK10;IFNGR1;IFNAR2
Signaling pathways regulating pluripotency of stem cellsGRB2;PIK3CB;PIK3R1;FZD1;AXIN2;AKT1;WNT6;SOX2;FZD3
Platelet activationGUCY1B3;VWF;PLCB2;STIM1;AKT2;BTK;PIK3CD;PRKG1;PIK3R2
Toll-like receptor signaling pathwayRELA;NFKBIAA;IFNA2;IFNA8;MAP2K7;IFNB;MAPK11;TLR1LB;PIK3R3B
NOD-like receptor signaling pathwayHSP90AA1;RELA;MAPK1;SGUT1;MAPK3;TAB3;ERBB2IP;CXCL2;HSP90AB1
RIG-I-like receptor signaling pathwayMAPK8;MAPK11;NFKB1;TBKBP1;NFKBIAA;IFNA8;IFNPHI1;IFNK;CASP10
T cell receptor signaling pathwayMAPK1;CBLB;MAP3K14;DEF6A;NCK2;VAV3;CD8B;BCL10;CABIN1
Fc epsilon RI signaling pathwayPLCG2;MAPK1;TNF;INPP5D;NRAS;MAP2K3;MAP2K6;FCER1A;PIK3R2
TNF signaling pathwayTNF;TAB2;CXCL2;MMP9;CCL2;MAPK3;BIRC3;MLKL;TRAF1
Leukocyte transendothelial migrationITGAM;CLDN7;MSN;CYBA;VASP;PRKCG;ACTN1;RAC2;NCF1
Neurotrophin signaling pathwayMAPK8;SH2B2;PLCG2;MAP3K5;CAMK2D;TRP53;AKT1;TRAF6;MAPK7
Retrograde endocannabinoid signalingGABRB2;MAPK11;GABRR2;PRKACA;GNG7;MAPK1;NAPEPLD;MAPK13;RIMS1
Dopaminergic synapseARRB2;GRIA1;ITPR3;PPP3CA;GRIN2B;ARNTL;PPP2R2C;SLC6A3;PPP2R3A
Inflammatory mediator regulation of TRP channelsPPP1CB;CALM1;ALOX12;PIK3R2;PLCB1;PTGER4;CAMK2D;PLA2G4D;IL1RAP
GnRH signaling pathwayGNRHR4;MAP2K4;MAP3K1;MAP2K2B;MAP2K4A;PTK2B;PLCB4;MAP2K3;CALM3
Progesterone-mediated oocyte maturationSPDYA;PRKACBB;MAP2K1;MAPK3;IGF1RA;RPS6KA3;MAPK13;PGR;ADCY1A
Prolactin signaling pathwayMAPK13;AKT1;PIK3CA;TNFSF11;PPIB;MAPK12;PIK3CG;FOXO3;SOS1
Amyotrophic lateral sclerosis (ALS)NEFL;TNF;CAT;MAP3K5;GRIA2;BID;MAP2K3;NEFM;PPP3CA
Epithelial cell signaling in Helicobacter pylori infectionRELA;PLCG2;PLCG1;NFKB1;MAP3K14;PTPN11;ATP6V1F;ATP6V1G1;JAM3
ShigellosisMAD2L2;MAPK13;RHOG;RELA;CTTN;ROCK1;IKBKG;BTRC;MAPK10
Salmonella infectionTLR5B;CD14;WASLB;CCL4L1;CASP1;PFN3;DYNC1LI1;PFN4;WASLA
PertussisSERPING1;C1QC;IL12A;ITGAM;C1RA;IRF1;NLRP3;GNAI1;IL6
LeishmaniasisHLA-DMB;MAPK1;HLA-DPA1;STAT1;PTGS2;MAPK3;HLA-DRB4;IRAK4;H2-AA
Chagas disease (American trypanosomiasis)C1QC;TICAM1;CCL3;GNAS;TGFBR1;C1QB;MAPK8;IFNG;CD3G
ToxoplasmosisIKBKB;LAMC1;LAMA1;PIK3R5;PDPK1;PIK3R1;H2-AA;IL12B;TNF
TuberculosisTLR1;FCGR4;IL10RA;PPP3CB;FCGR2C;CAMK2B;PPP3CC;MAPK10;Ifna15
Hepatitis CTRP53;OSTN;NFKBIA;IRF9;PDPK1;TRADD;PPP2CA;CLDN15;STAT3
Influenza APIK3R2;TNFRSF10B;IL12B;TRIM25;IFNA13;OAS1A;IRF3;CCL2;CCL5
Epstein-Barr virus infectionHLA-DRB4;MDM2;POLR3F;CCNA2;TBK1;POLR3G;POLR3GL;HSPA1B;MAP2K3
Proteoglycans in cancerTLR2;PTPN11;ROCK1;FZD8;WNT3A;RAF1;RRAS;PLCE1;WNT5B

MAPK12 has several biochemical functions, for example, ATP binding, MAP kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPDK2;LMTK3;PIM1;ABCB1;UBE2G2;NME6;SRC;MAST4;CHKA
MAP kinase activityMAPK14A;MAPK15;MAPK13;MAPK1;MAPK4;MAPK14;MAPK12B;NLK;NLK2
magnesium ion bindingSRR;PGM3;NUDT7;PIF1;NUDT18;RPS6KA2;PRTFDC1;ENDOV;MARK2
protein bindingS100A1;FAT4;PRADC1;PSMG1;HIST1H2AL;PRKX;DKK1B;CARHSP1;MKI67IP
protein serine/threonine kinase activityRAF1A;ACVR1;CIT;SMOK2B;MAPK12A;DCAMKL2;STK38;SNRKB;BMPR1B

MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.

SIAH1; saicar; PKM; PTPN4; SRPK1; DUSP1; DLG1; PKN1; TERF1; GTF2I; PDGFRL; MAPK1; PRPF4B; MAPK15

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