MAPK12
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Official Full Name
mitogen-activated protein kinase 12
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Background
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. -
Synonyms
MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitoge;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK12 Related Research Area
- MAPK12 Related Signal Pathway
MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | NFKB2;CACNA1H;PRKACB;JIP1;FGF12;MAPK3;FGFR1A;MOS;CACNB4A |
| Rap signaling pathway | RHOA;CALM1;PRKD1;AKT2;RASGRP3;FGF10;MRAS;KLK1B4;PIK3R2 |
| FoxO signaling pathway | CCNG2;PRKAB1A;TGFB3;PIK3R3B;CCNB1;IGF1RA;CCND2A;MAP2K2A;GRB2 |
| Sphingolipid signaling pathway | AKT2;MAPK1;FYN;MAP2K1;PPP2R5A;RHOA;MAP2K2;MAP3K5;AKT1 |
| Oocyte meiosis | CDC23;IGF1RA;ANAPC11;CDC20;ADCY2B;PPP2R5D;PPP3CCB;SLK;PRKACAB |
| Adrenergic signaling in cardiomyocytes | GNAI2;MAPK14;ATP1B1;AGTR1A;PPP1CBL;SLC14A2;MAPK3;PIK3R5;ADRB1 |
| VEGF signaling pathway | PIK3CB;SHC2;PIK3CA;PRKCB;SPHK1;HRAS;RAC1;KRAS;PTGS2B |
| Osteoclast differentiation | LILRA2;CSF1R;CYBB;SIRPB1;LCP2;TEC;LILRB3;NFKB1;NFKB2 |
| Signaling pathways regulating pluripotency of stem cells | PIK3CG;BMP4;RAF1;ID1;FZD3;WNT10B;BMPR1A;PIK3CA;WNT5A |
| Platelet activation | FYN;STIM1;P2RY12;PRKACA;GP1BB;MYL12B;TBXAS1;ITGA2B;MYLK3 |
| Toll-like receptor signaling pathway | AKT2;NFKBIAA;TLR3;IL1B;RAC1;CXCL8B.3;TNF;NFKB1;MAPK1 |
| NOD-like receptor signaling pathway | MAPK14B;IL6;CASP8;MAPK1;MAPK12;MAPK12B;CXCL8B.3;IL18;NFKBIA |
| RIG-I-like receptor signaling pathway | MAPK10;IRF7;IFNA13;DHX58;IFNE;NT5C3;IFNA5;TRAF6;IFIH1 |
| T cell receptor signaling pathway | ZAP70;PIK3CB;CD3E; CD3D;GRAP2;FYN;OXSR1A;CBLC;LCK;PPP3R2 |
| Fc epsilon RI signaling pathway | IL3;AKT2;MAP2K6;RAC2;SYK;RAC1;MAP2K4;MAPK13;PLCG1 |
| TNF signaling pathway | BIRC3;ICAM1;Casp3;MAP2K4;AKT1;RIPK1;LTA;CXCL3;CXCL1 |
| Leukocyte transendothelial migration | PLCG1;PRKCB;EZR;PTK2B;CLDN14;ACTN1;NOX3;VCL;MYL10 |
| Neurotrophin signaling pathway | MAP3K1;MAPK3;RPS6KA6;PLCG2;SHC4;NGF;MAP2K7;AKT1;NFKBIA |
| Retrograde endocannabinoid signaling | NAPEPLD;PRKACB;PRKCB;GNG7;Adcy4;RIMS1;GABRE;GNB2;GABRR3 |
| Dopaminergic synapse | DRD3;PRKACB;PPP2R2A;PPP2R1A;GNAI3;GNGT2;KIF5C;KCNJ6;PPP1CB |
| Inflammatory mediator regulation of TRP channels | PLA2G4C;PTGER2;CALM1;MAPK13;TRPV2;SRC;PIK3CD;BDKRB2;TRPV4 |
| GnRH signaling pathway | CAMK2D2;CDC42;PLD2;MAPK12;CALM3A;GNA15.4;MAPK9;FSHB;GNAS |
| Progesterone-mediated oocyte maturation | FZR1A;CPEB1B;RPS6KA3;RPS6KA2;MAPK3;CPEB1A;CDC16;INS1;GNAI1 |
| Prolactin signaling pathway | ESR1;CSH;AKT1;SHC3;AKT2;STAT5B;LHCGR;STAT1;SOCS1 |
| Amyotrophic lateral sclerosis (ALS) | GRIA1;TOMM40L;BID;GRIA2;GRIN2D;BAX;DAXX;CASP9;NEFH |
| Epithelial cell signaling in Helicobacter pylori infection | NFKB1;ATP6V1G1;PAK1;NOD1;SRC;CXCL1;ATP6V1H;ATP6V0A4;TJP1 |
| Shigellosis | IKBKB;MAPK11;U2AF1L4;UBE2D2;MAPK12;PFN1;PFN4;DIAPH1;ARPC5L |
| Salmonella infection | KLC1A;TLR4;FLNA;CXCL3;WASB;PKN2;MAPK10;RAC1A;NFKB1 |
| Pertussis | CXCL6;IL12B;IL1B;CALM4;CD14;C4BPA;IRAK1;TNF;C1S |
| Leishmaniasis | IL1B;ITGA4;IL4;HLA-DOA;STAT1;RELA;NFKBIA;NOS2;IFNGR2 |
| Chagas disease (American trypanosomiasis) | GNAQ;IRAK1;PIK3CB;CD3E; CD3D;IL12B;MAPK1;PIK3CA;TGFBR1;GNA14 |
| Toxoplasmosis | MAPK9;CYCS;HSPA8;PPIF;TRAF6;TGFB1;BIRC8;PDPK1;BIRC3 |
| Tuberculosis | CLEC4M;CAMK2A;IFNA8;TLR2;CALML3;TGFB2;IL12A;EEA1;IFNG |
| Hepatitis C | CLDN7;CLDN3;IRF3;GRB2;NR1H3;TNF;PPP2R2D;CLDN5;BRAF |
| Influenza A | STAT2;NXT2;HLA-DRA;CXCL10;Ifna11;FURIN;RNASEL;TNF;MYD88 |
| Epstein-Barr virus infection | POLR2A;NCOR2;PSMC3;PIK3CG;CR2;PTMA;IRF3;AKAP8L;MAP2K7 |
| Proteoglycans in cancer | SDC4;VAV2;PTPN6;GPC1;ITGAV;FLNC;PTPN11;HCLS1;FLNA |
MAPK12 has several biochemical functions, for example, ATP binding, MAP kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CLK4;VMHCL;AURKC;TLK1B;RENBP;UBE2IB;PRKCHA;DHX36;PRKACG |
| MAP kinase activity | MAPK12B;MAPK12A;MAPK15;MAPK8B;MAPK3;MAPK11;MAPK4;MAPK14B;MAPK6 |
| magnesium ion binding | ERN2;IMPA2;IRAK4;SRPK2;PKLR;SIK2;MAP2K7;TREX2;PTENA |
| protein binding | Raet1a;C1GALT1C1;PTPN23;UPF3A;S100A4;GLUD1;PJA1;ARF5;RQCD1 |
| protein serine/threonine kinase activity | ADCK2;GM4922;PHKG1A;MAP2K6;LATS2;RPS6KB1B;GRK1A;OXSR1A;BRAF |
MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.
SIAH1; saicar; PKM; PTPN4; SRPK1; DUSP1; DLG1; PKN1; TERF1; GTF2I; PDGFRL; MAPK1; PRPF4B; MAPK15
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