"MAPK12" Related Products

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Recombinant Human MAPK12 protein, GST-tagged

Cat.No.: MAPK12-27H
Product Overview: Recombinant Human MAPK12 fused with GST tag at N-terminal was expressed in Insect cells.
Description: P38γ is a member of the p38 MAPK family which is activated in response to stress. p38-gamma gene was mapped to 22q13.3 and functions as a signal transducer during differentiation of myoblasts to myotubes. Enforced localization of p38γ in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. p38γ increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle.
Source: Insect cells
Species: Human
Tag: GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~66 kDa
Purity: >90%
Applications: Kinase Assay, Western Blot
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/uL
Gene Name: MAPK12 mitogen-activated protein kinase 12 [ Homo sapiens ]
Official Symbol: MAPK12
Synonyms: MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitogen-activated protein kinase p38 gamma; ERK3; SAPK-3; P38GAMMA;
Gene ID: 6300
mRNA Refseq: NM_002969
Protein Refseq: NP_002960
MIM: 602399
UniProt ID: P53778
Chromosome Location: 22q13.3
Pathway: Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDO in myogenesis, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; DSCAM interactions, organism-specific biosystem;
Function: ATP binding; MAP kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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