| MAPK signaling pathway |
MAPK10; ARRB2B; RAF1A; ARRB2A; MAP2K2; MYCB; NTF4; PPP3R1; RRAS2; CACNA1G |
| ErbB signaling pathway |
AKT2; PAK4; HBEGFA; GAB1; MTOR; CBLC; GRB2; RPS6KB2; HBEGFB; NCK1 |
| Ras signaling pathway |
IGF1; PIK3R3; ETS2; KIT; KITLG; PLA2G4C; GNG2; CALM1; ARF6; RAC2 |
| Rap signaling pathway |
VEGFC; FGF5; TEK; PDGFRB; ITGB2; RASSF5; NGFR; PLCE1; KIT; MAPK1 |
| cGMP-PKG signaling pathway |
PDE2A; VDAC2; MYH7; INS; NPR2; PPP3R2; MYLK; NOS3; ROCK2; GUCY1A3 |
| cAMP signaling pathway |
HHIP; HTR4; RAP1A; RAF1; RAP1B; GNAI1; ATP1B2; MAPK9; BAD; GRIN3B |
| Chemokine signaling pathway |
IL-8; PARD3; PIK3CB; GSK3B; PRKACB; CXCR1; VAV1; CCL16; CRKL; CXCL12 |
| HIF- signaling pathway |
INS2; EP300; TCEB2; MKNK1; AKT2; MAP2K1; PIK3CA; CAMK2A; IFNG; TLR4 |
| FoxO signaling pathway |
AGAP2; MAP2K2B; USP7; STK4; CDKN2D; FOXO1A; GADD45AB; INS2; MDM2; CCND2 |
| Sphingolipid signaling pathway |
PLCB4; FYN; SPHK1; MAPK10; GNAI2; PPP2CA; PTEN; NRAS; PRKCG; GNAQ |
| Phospholipase D signaling pathway |
RALGDS; PLA2G4A; LPAR2; DGKD; KIT; RRAS; CYTH2; AKT1; PLD2; PLCB4 |
| Oocyte meiosis |
YWHABA; CDC26; CAMK2D; Ar; SKP1; YWHABL; YWHABB; ITPR1; IGF1RB; PRKACBA |
| mTOR signaling pathway |
HIF1AB; VEGFA; EIF4BB; ULK3; TSC2; STK11; ULK2; RPS6; INS2; PIK3CA |
| PIK-Akt signaling pathway |
AKT2; PPP2R5D; GNGT2; IL6; NGFR; IL4; GNB2; LAMB1; LAMA3; PGF |
| Adrenergic signaling in cardiomyocytes |
ADRB2B; CACNA1D; MAPK3; GNAS; PLCB4; PPP2R3C; PPP2R5CB; MAPK12B; PRKCA; GNAI2B |
| Vascular smooth muscle contraction |
ACTG2; PLA2G2D; PRKG1; EDNRAA; AGTR1B; GNA15.4; CALML3; MYL6; CALM1A; PPP1CBL |
| Dorso-ventral axis formation |
EGFRA; ETV7; MAP2K1; PPP1R2P9; SOS1; MAPK3; CPEB1A; NOTCH1A; NOTCH3; NOTCH2 |
| TGF-beta signaling pathway |
BMPR1A; TGFB2; INHBA; TGFB3; ID2B; CUL1B; RHOA; SMAD7B; NOG; BMPR1BB |
| Axon guidance |
PLXNC1; PPP3CC; AP2S1; IL17RD; SCN8A; FRS3; SPNA2; RGMB; ACTR2B; DPYSL5A |
| VEGF signaling pathway |
CDC42; PRKCA; PLA2G4F; PIK3R3A; PRKCBA; MAPK12B; PIK3CD; PTGS2A; HSPB1; PPP3R1 |
| Osteoclast differentiation |
SPI1; MAPK10; MAP2K1; PPARG; MAP2K7; TNF; MAPK8; PIK3CA; PIK3R2; SIRPB1 |
| Focal adhesion |
PPP1CBL; RAC1A; RAC2; VAV3B; PDGFC; ACTB1; THBS3A; PARVA; CDC42; MYLK |
| Adherens junction |
EP300; ERBB2; PVRL4; SRC; MAP3K7; WASF1; FGFR1; ACP1; SMAD2; YES1 |
| Gap junction |
MAP2K2B; GUCY1A3; GNAIA; CX35B; ADCY2B; PLCB1; GJA1; GUCY1B3; TUBB2; MAP2K2 |
| Signaling pathways regulating pluripotency of stem cells |
WNT9A; LIF; PCGF2; BMPR1A; SMAD4; PIK3CG; MAP2K1; ACVR2A; SMAD5; AXIN2 |
| Platelet activation |
PLCB4; COL24A1; VWF; APBB1IP; GUCY1B3; PLA2G4D; PRKG1; PRKCI; VASP; MYLK |
| Toll-like receptor signaling pathway |
IFNA17; NFKBIAA; IFNA4; CRFB2; FADD; AKT2L; IRF7; IFNA8; RELA; CCL4L2 |
| NOD-like receptor signaling pathway |
IKBKG; MAPK8A; CARD18; CXCL8B.3; NFKB1; CASP8; IL8L1; IKBKB; PYDC1; MAPK11 |
| Natural killer cell mediated cytotoxicity |
RAC1; TNFSF10; FASLG; PTPN11; SH3BP2; VAV2; KIR2DL3; IFNA6; ITGB2; KLRC3 |
| T cell receptor signaling pathway |
MAPK11; SHB; PIK3CB; LCP2; MAP2K1; IL5; DLG1; FYN; CD28; DBNLB |
| B cell receptor signaling pathway |
STAP1; MAP2K1; FOS; CDK6; RAC2; BCL10; INPPL1; PLEKHA1; CTNNB2; PIK3R1 |
| Fc epsilon RI signaling pathway |
LCP2; MAPK1; VAV1; MAP2K2; LAT; IL4; PIK3CA; VAV3; PIK3CB; VAV2 |
| Fc gamma R-mediated phagocytosis |
RAC1; PRKCA; ARPC5L; WASF1; VAV2; SYK; ASAP1; SPHK1; GAB2; PLA2G6 |
| TNF signaling pathway |
CREB3L2; CCL2; MAP2K6; AKT1; RELA; MAPK9; CREB5; SELE; CXCL1; IL6 |
| Circadian entrainment |
PER2; GNAI3; KCNJ5; GNB2; PLCB4; MTNR1A; RPS6KA5; PRKACG; GUCY1B3; NOS1AP |
| Long-term potentiation |
PRKCA; PPP1CC; BRAF; PRKCB; CALM3; ATF4; PPP3R2; GRM5; GRIN2A; PRKCG |
| Neurotrophin signaling pathway |
PLCG2; NTF4; ARHGDIB; MAPK1; PRKCD; MAPK13; CDC42; NFKBIB; CALM4; RAC1 |
| Retrograde endocannabinoid signaling |
MAPK11; MAPK3; GABRG3; GABRP; GABRG1; PLCB2; MAPK12; MAPK10; GABRR2; GABRQ |
| Glutamatergic synapse |
GNG13; PRKCB; GNGT2; PLCB4; TRPC1; SLC17A6; SLC38A1; PLA2G4C; GNB4; PRKACA |
| Cholinergic synapse |
NRAS; KCNQ5; GNAI1; PRKCA; CAMK2G; JAK2; KCNJ14; PRKCB; PIK3CA; GNG4 |
| Serotonergic synapse |
HTR3E; ALOX8; ALOX15; PTGS2; CYP2D26; TPH1; HTR1B; CYP2C38; CYP2D10; CYP2C54 |
| Long-term depression |
NOS1; GUCY1A3; GNA11; GNAI1; PPP2R1B; PLCB4; GNAI2; KRAS; RAF1; GRIA1 |
| Regulation of actin cytoskeleton |
ACTB; PPP1CA; INS; FN1A; PIK3R5; PAK2; ITGA1; HRASA; RRAS; FGF8 |
| Insulin signaling pathway |
PPP1R3CB; HK1; EIF4E1C; CALM; FBP1A; RPS6; MKNK2B; PPP1R3C; PIK3R1; PRKACAB |
| GnRH signaling pathway |
FSHB; MMP2; CAMK2D; PRKACAA; CAMK2D1; RAF1B; ADCY1A; ITPR3; PRKCB; PTK2B |
| Progesterone-mediated oocyte maturation |
IGF1RB; MAPK12A; KRAS; MAPK9; PIK3R3; CDC25C; HSP90AA1; CCNB3; HSP90AB1; PRKACAB |
| Estrogen signaling pathway |
GRB2; PIK3R5; PIK3CG; MMP2; PRKCD; AKT2; CALM1; HSP90AA1; CREB3L2; FOS |
| Melanogenesis |
GNAI2; FZD3; FZD9B; CREB3L1; TYRP1B; PRKCB; KIT; Adcy4; PRKACBA; KITLGB |
| Prolactin signaling pathway |
CSH; SOCS7; PIK3R3; MAPK10; SOCS5; GALT; INS1; SHC3; PIK3CG; PRP2 |
| Thyroid hormone signaling pathway |
TRP53; PIK3R1; MED24; PIK3CG; MAP2K2; SIN3A; RXRA; ATP1A4; MED30; DIO3 |
| Oxytocin signaling pathway |
CACNG7; CACNG6; PLCB4; MAP2K2; PRKAA1; GNAO1; PRKACG; PIK3R1; PPP3R1; RYR1 |
| Type II diabetes mellitus |
INSR; SOCS2; PDX1; IRS1; SOCS4; PIK3CG; INS; SOCS1; PKM2; HK2 |
| Aldosterone-regulated sodium reabsorption |
INS1; SCNN1G; FXYD4; IGF1; NR3C2; PIK3CD; ATP1A3; INS2; PRKCA; PRKCB |
| Alzheimers disease |
Atp5g2; NDUFA10; PPP3CC; NDUFS6; COX7B2; TNF; ERN1; SNCA; CALM3; MAPK1 |
| Prion diseases |
C6; LOC100033925; NOTCH1; IL6; C8A; Hc; HSPA1A; NCAM1; C8B; PRNP |
| Alcoholism |
HIST1H2BG; GNG12; HIST1H4I; HIST1H2BP; GNB2; GNG11; GNG8; GNAI2; CREB5; HIST1H4L |
| Shigellosis |
NFKBIA; BTRC; HCLS1; MAPK1; FBXW11; ACTG1; IKBKG; IKBKB; ELMO2; VCL |
| Salmonella infection |
RHOGC; WASB; MAPK1; TLR4BB; CASP1; MAPK12A; CDC42; MAPK8A; ARPC5L; ARPC5B |
| Pertussis |
IRF8; IRF1; ITGAM; CFL2; C1RA; ITGB2L; AMCF-II; CXCL5; GNAI2; ITGB2 |
| Leishmaniasis |
ELK1; TLR2; MAPK12; IL1B; ITGB1; HLA-DQA2; NCF1; FCGR3A; NFKBIB; IFNGR1 |
| Chagas disease (American trypanosomiasis) |
SMAD3; GNA14; PLCB4; Il2; Fasl; MAPK9; MAPK13; PPP2R2C; MAPK11; NOS2 |
| Toxoplasmosis |
IRAK4; TGFB3; RELA; LAMA1; HLA-DPB1; LY96; BIRC7; IRGM1; LAMB3; GNAI2 |
| Tuberculosis |
FCGR3; AKT1; NFYA; MYD88; MRC2; FADD; AKT2; LAMP1; MAPK11; NFYB |
| Hepatitis C |
PIK3CA; PIK3R3; TYK2; OCLN; IKBKG; IKBKB; CLDN9; NFKBIA; MAVS; IFN-a |
| Hepatitis B |
CASP8; Ifna15; IFNAR1; CXCL8; PTEN; RB1; TGFBR1; FADD; EP300; TP53 |
| Influenza A |
PRSS2; PLG; NLRX1; MAPK9; PIK3CB; IL12B; IL33; MAP2K2; BLA; SLC25A6 |
| Pathways in cancer |
CCDC6; Shh; MAX; PLEKHG5; TRAF5; FGFR1; FGF16; TGFB1; FGF17; NRAS |
| Viral carcinogenesis |
CDC42; HRAS; CASP8; HIST1H4I; CCNA1; EP300; NFKB2; RELA; HIST1H2BE; TRAF5 |
| Proteoglycans in cancer |
Fzd4; CBL; FZD1; ROCK1; MAPK13; ERBB2; WNT3; DDX5; FGF2; HGF |
| Colorectal cancer |
TGFB2; AKT1; LEF1; Casp3; MSH2; MLH1; TP53; RAC3; MAPK9; BAD |
| Renal cell carcinoma |
AHA-1; FH; GRB2; TGFB3; PIK3R3; FH1; PAK2; VHL; MAPK3; MAP2K1 |
| Pancreatic cancer |
RAC1; RAC2; KRAS; TGFB2; IKBKB; VEGFA; TGFA; CDC42; PIK3R1; SMAD4 |
| Endometrial cancer |
MAPK3; MLH1; PTEN; SOS1; AKT1; ILK; PIK3R3; ERBB2; PIK3CD; KRAS |
| Glioma |
IGF1; RB1; MDM2; PRKCG; CCND1; SHC1; CAMK2B; PRKCA; HRAS; PLCG1 |
| Prostate cancer |
SPRY1; NKX3-1; ERBB2; Pdgfa&Pdgfb; IKBKB; TCF7L2; BRAF; PIK3R5; RAF1; FOXO1 |
| Thyroid cancer |
TCF7L2; TP53; MAP2K2; PPARG; RET; MAPK3; TFG; MAPK1; PAX8; NRAS |
| Melanoma |
FGF17; PIK3R2; FGF14; PIK3R3; MAP2K2; PDGFRB; FGF12; FGF5; PIK3R1; MAP2K1 |
| Bladder cancer |
DAPK1; UPK3A; FGFR3; E2F3; MAP2K1; MMP2; DAPK2; CXCL8; E2F1; MAPK3 |
| Chronic myeloid leukemia |
CBLB; RUNX1; TGFBR1; PIK3CA; CTBP2; KRAS; MAPK1; SHC2; RAF1; AKT2 |
| Acute myeloid leukemia |
LEF1; MAP2K2; HRAS; RPS6KB1; PML; FLT3; PIK3CG; TCF7L2; NRAS; KIT |
| Non-small cell lung cancer |
FHIT; RB1; PRKCB; TRP53; MAPK3; KRAS; PIK3CG; BRAF; AKT1; RXRB |
| Central carbon metabolism in cancer |
RAF1; PGAM1; AKT2; PDGFRB; PFKP; NTRK1; PTEN; NTRK3; IDH1; AKT1 |
| Choline metabolism in cancer |
MAP2K2; WASF1; EGF; GRB2; AKT2; HRAS; RPS6KB2; SP1; LYPLA1; PLA2G4F |
