MAPK3
-
Official Full Name
MAPK3 mitogen-activated protein kinase 3
-
Synonyms
MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK3 Related Articles
- MAPK3 Related Research Area
- MAPK3 Related Signal Pathway
MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | AKT2;SRFA;NLK2;MKNK1;RAC2;FGFR1A;ATF4B1;GADD45B;CACNB4A |
| ErbB signaling pathway | RPS6KB2;SHC2;MAPK8B;ARAF;PAK6B;BTC;SHC1;MAP2K7;MYCB |
| Ras signaling pathway | ETS2;GNB4;Fasl;PLA2G4F;RASGRP3;GNG7;MAPK3;MAPK8;RASAL2 |
| Rap signaling pathway | FYB;FGF5;MAPK1;HRAS;F2RL3;MAPK12;ITGB2;CALM1;MAP2K2 |
| cGMP-PKG signaling pathway | GNA12;LOC100328615;PIK3R5;IRS4;NFATC2;PLN;TRPC6;ATP1A3;ATP1A4 |
| cAMP signaling pathway | GNAI1;NPY1R;GABBR2;ATP1A1;CAMK2B;MAPK10;GRIA4;OXTR;HTR6 |
| Chemokine signaling pathway | GNG11;GNGT2;CCL24;XCR1;CCL16;CCL2;FGR;LOC100033925;NCF1 |
| HIF- signaling pathway | PDK1;FLT1;PRKCB;VEGFA;LDHA;INS2;RPS6;HK1;MKNK1 |
| FoxO signaling pathway | PRKAA2;SGK2;IKBKB;INSRA;FOXO1B;PLK3;MAPK9;STK4;KLF2B |
| Sphingolipid signaling pathway | NOS3;S1PR5;RAC2;TNF;PLD2;ROCK1;PRKCG;PIK3CD;SPTLC1 |
| Phospholipase D signaling pathway | SOS1;INS2;RALGDS;AGPAT3;RHEB;DGKZ;Adcy4;PLD1;CYTH3 |
| Oocyte meiosis | CPEB1B;CUL1;BTRC;REC8B;CALM2A;CALM1B;ADCY1B;PRKACBB;INS |
| mTOR signaling pathway | TNF;RPS6KA3A;INSB;PTENA;CAB39L;RPS6KB1B;STK11;PIK3CB;PRKCB |
| PIK-Akt signaling pathway | IGF1R;IL6;RAC1;TLR4;CREB3L3;IL4R;FGF5;TNC;MAPK1 |
| Adrenergic signaling in cardiomyocytes | PIK3CD;ADRA1BB;CAMK2A;PRKACA;TMEM8C;MAPK1;GNAI3;GNAI2B;ADRB3A |
| Vascular smooth muscle contraction | PPP1R14A;CALD1;PRKCDA;AGTR1B;KCNMB4;MAP2K2;CALM1B;PLA2G4D;ADCY1B |
| Dorso-ventral axis formation | SPIRE2;NOTCH1;NOTCH2;NOTCH1B;NOTCH1A;KRAS;ETV7;MAPK1;GRB2A |
| TGF-beta signaling pathway | ID1;RBL1;RHOAD;GDF7;BAMBI;NBL1;INHBB;ID2;BMP5 |
| Axon guidance | Ntng2;TRPC7;NADL1.1;DPYSL5;SEMA3D;PITPNA;EPHA2A;SEMA3B;AP2S1 |
| VEGF signaling pathway | SH2D2A;MAPK14B;PPP3CCB;MAPKAPK2A;SPHK1;SPHK2;HRASB;MAPK12A;PPP3CCA |
| Osteoclast differentiation | TEC;LCK;LILRA1;FYN;LILRB3;AKT2;TGFBR2;FOSB;FCGR2A |
| Focal adhesion | PPP1R12A;THBS3;COL2A1B;ACTG1;LAMC1;CAPN2B;XIAP;ACTN3;COL5A2A |
| Adherens junction | PVRL1B;PVRL4;SMAD3A;RAC3A;SNAI1;NLK1;LMO7;CDC42L2;FARP2 |
| Gap junction | GJD2;TUBA8L3;CDK1;TUBA4L;GNA11B;TUBA2;PRKCA;HRAS;MAPK1 |
| Signaling pathways regulating pluripotency of stem cells | GSK3B;WNT6;AKT1;HESX1;HOXB1;FZD1;WNT5B;LEFTY2;WNT1 |
| Platelet activation | MYL12A;GNAI1;PLA2G4A;FCER1G;VASP;LYN;STIM1;PTGIR;PRKACB |
| Toll-like receptor signaling pathway | STAT1B;AKT2;MAPK8B;IFNA12;IFNA6;IRF5;CD86;MAP2K2B;CCL3L3 |
| NOD-like receptor signaling pathway | CXCL2;MAPK12;MAPK11;IL6;BIRC3;NAIP1;MAPK9;HSP90AA1.2;HSP90AA1 |
| Natural killer cell mediated cytotoxicity | PPP3CA;RAET1D;TNFSF10;RAF1;FCGR3;FAS;KRAS;ARAF;HLA-E |
| T cell receptor signaling pathway | PPP3CB;NCK2;VAV2;RHOA;NFATC1;CD3E; CD3D;GSK3B;MAP2K7;MAP3K14 |
| B cell receptor signaling pathway | IGHM;SOS1;HDAC5;NFATC3;DAPP1;NFATC1;SLA2;AKT1;HRAS |
| Fc epsilon RI signaling pathway | RAF1;VAV2;MAPK12;PLCG2;IL3;GM-CSF;FYN;MAPK9;MS4A2 |
| Fc gamma R-mediated phagocytosis | FCGR2B;MARCKSL1;LIMK2;PLA2G4D;PPAP2B;PIP5K1A;AKT1;DOCK2;PIK3CD |
| TNF signaling pathway | PIK3R2;PIK3R3;NFKBIA;IL15;PIK3CA;IL1B;Ccl12;TNFRSF1B;AKT1 |
| Circadian entrainment | GRIA2;RYR1;PLCB2;KCNJ9;GNAO1;PRKACG;KCNJ5;ITPR3;PRKG1 |
| Long-term potentiation | RAP1B;PRKCG;RAP1A;GRM1;PRKACB;RPS6KA1;CALM2;CAMK2D;GRIN2D |
| Neurotrophin signaling pathway | MAPK9;PIK3CA;ATF4;MAPK8;MAGED1;CDC42;ARHGDIG;CALM4;ABL1 |
| Retrograde endocannabinoid signaling | GNG10;GNG8;GRIA3;PTGS2;GABRR2;PRKCB;MAPK12;GNB2;GNG3 |
| Glutamatergic synapse | SHANK2;GLUL;GRM4;GRM6;PRKCB;GNGT2;GRIN2C;SLC1A7;PPP3CC |
| Cholinergic synapse | GNGT1;PRKACB;CHAT;MAPK3;CAMK2G;KCNJ2;ITPR1;GNB2;CHRNB4 |
| Serotonergic synapse | PLA2G4A;PRKCB;PLA2G4C;ITPR1;TRPC1;TPH1;PTGS2;GNGT2;SLC6A4 |
| Long-term depression | PPP2CB;PLCB2;GRM1;GRIA1;RAF1;GUCY1B3;IGF1R;HRAS;GNAS |
| Regulation of actin cytoskeleton | RRAS;BDKRB2;ARHGEF12;FGF20;PDGFRA;MYL12.2;PTK2AB;CD14;PTK2AA |
| Insulin signaling pathway | FLOT2A;PTPRFB;PRKAA2;IKBKB;PRKCZ;FBP2;PYGL;PPP1R3C;MAPK9 |
| GnRH signaling pathway | PTK2BB;ITPR1;PRKACB;CAMK2D1;MAP3K3;PRKCA;ATF4B1;SOS1;SRC |
| Progesterone-mediated oocyte maturation | AKT2;ANAPC4;MAPK14B;AKT3A;ADCY1A;HSP90AA1.2;MAPK12;GNAIA;ARAF |
| Estrogen signaling pathway | SHC1;PIK3R1;ESR1;HSPA1L;CALM1;CREB3L1;HRAS;PRKCD;PIK3CG |
| Melanogenesis | PRKACBA;CREB3L3;TYRP1;FZD2;PRKACAB;CALM1;Kitl;WNT5B;ASIP |
| Prolactin signaling pathway | GRB2;IRF1;PIK3R1;ELF5;SOCS4;PRP2;SIRPA;MAPK10;CCND2 |
| Thyroid hormone signaling pathway | RHEB;HDAC1;NOTCH3;PRKCB;NRAS;PRKACG;MED13L;RCAN1;MED17 |
| Oxytocin signaling pathway | PIK3CB;CACNG7;GUCY1A3;CACNB1;MAPK3;KCNJ14;RYR2;CACNA2D3;KRAS |
| Type II diabetes mellitus | MAFA;SOCS1;HK2;PIK3CG;PIK3R1;PIK3R3;MAPK10;PDX1;PRKCZ |
| Aldosterone-regulated sodium reabsorption | ATP1B2;FXYD2;ATP1B1;ATP1A2;INS1;MAPK1;PIK3CG;SGK1;KRAS |
| Alzheimers disease | CASP9;NDUFS2;CASP12;COX7A1;NDUFS6;ATP5A1;CAPN1;MAPT;APOE |
| Prion diseases | PRKACB;CCL5;C8B;C1QB;IL1A;C8A;PRKACA;C5;NCAM2 |
| Alcoholism | HIST1H2AJ;SOS1;HIST1H3G;HIST2H3C2;HIST2H4A;CAMKK2;GNB2;HIST1H3H;HIST1H2BD |
| Shigellosis | RHOG;MAPK12;ACTB;PFN2;ACTG1;MAPK8;WASL;CD44;RELA |
| Salmonella infection | CCL4;RAC1;MAPK14A;DYNC1I2A;ROCK2B;CXCL1;ACTB;WAS;KLC1A |
| Pertussis | FOS;CALM4;C4BP;CALM2;C5;CALML3;C1QC;C1S;CALM1 |
| Leishmaniasis | HLA-DOB;HLA-DRB1;HLA-DOA;STAT1;TGFB2;PTGS2;FOS;IFNGR2;MAPK1 |
| Chagas disease (American trypanosomiasis) | TICAM1;IFNB1;BDKRB2;PIK3CG;PIK3R2;CALR;TGFB3;RELA;FOS |
| Toxoplasmosis | SOCS1;MAPK1;IL10RA;HSPA1B;BIRC3;STAT3;PIK3R5;NOS2;Toxoplasma Gondii Microneme Protein MIC3 |
| Tuberculosis | RFXAP;HLA-DOA;ATP6V0C;PPP3CB;MYD88;NFYB;RAF1;RELA;Itgam&Itgb2 |
| Hepatitis C | NFKBIA;TRAF6;MAPK3;EIF2AK2;IFNAR1;TLR3;IFNA4;PPP2R1A;EIF2AK4 |
| Hepatitis B | TLR4;TRP53;MAP3K1;CREB3L1;CCND1;EP300;Fasl;CCNA2;Casp3 |
| Influenza A | MAVS;HSPA1B;MAP2K6;NXF3;PRSS2;MAP2K2;PABPN1L;PIK3CB;HNRNPUL1 |
| Pathways in cancer | TPM3;MMP2;ITGAV;PIK3R1;CXCL12;ITGA3;APPL1;WNT5B;ITGB1 |
| Viral carcinogenesis | MAD1L1;RELA;HDAC2;HPN;HIST1H4F;HIST1H4C;GRB2;UBR4;HIST1H2BF |
| Proteoglycans in cancer | TGFB1;GPC3;TIMP3;PTCH1;ACTB;WNT9A;HSPB2;PPP1R12A;ELK1 |
| Colorectal cancer | ARAF;PIK3R1;TCF7L2;MAPK9;DCC;TCF7;BAX;Casp3;PIK3R2 |
| Renal cell carcinoma | RAP1A;RAF1;RAPGEF1;HGF;AHA-1;PAK6;CUL2;PDGFB;VHL |
| Pancreatic cancer | RAC1;TGFB2;PIK3R5;RAD51;STAT3;ARAF;MAPK1;MAPK3;TRP53 |
| Endometrial cancer | TCF7;PIK3CD;NRAS;PIK3CG;RAF1;HRAS;APC2;MLH1;ERBB2 |
| Glioma | PTEN;SHC4;TGFA;CALM2;PLCG1;PIK3CA;KRAS;PIK3R5;MAPK1 |
| Prostate cancer | HSP90B1;CCNE1;INSRR;SMARCC2;RELA;PIK3R1;PIK3R3;LEF1;PDGFRA |
| Thyroid cancer | NCOA4;TP53;CCND1;MAPK3;TPM3;BRAF;PPARG;NTRK1;RXRB |
| Melanoma | TP53;CDH1;PDGFD;FGF14;AKT1;FGF10;MET;PIK3R3;PDGFRB |
| Bladder cancer | MDM2;E2F3;CDKN2A;KRAS;MMP9;E2F1;EGF;MAPK1;TRP53 |
| Chronic myeloid leukemia | PIK3CB;RELA;TGFB1;NFKB1;AKT2;SOS1;HDAC2;CTBP1;BAD |
| Acute myeloid leukemia | RUNX1;GRB2;PML;STAT3;RPS6KB1;SPI1;PIK3R1;CCNA1;MAPK1 |
| Non-small cell lung cancer | PRKCG;EML4;PIK3CD;PLCG2;TGFA;PIK3CG;BRAF;RASSF1;FHIT |
| Central carbon metabolism in cancer | G6PDX;MAP2K1;PIK3CG;LDHA;NRAS;PGAM2;SLC2A2;HK3;IDH1 |
| Choline metabolism in cancer | PIP5K1B;SOS1;PIK3CB;PIK3R3;RHEB;TSC2;PLA2G4B;DGKG;FOS |
MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MYO1H;ORC5;DDX51;EPHA8;PCCA;CDKL2;UBE2D4;PSMC1A;CKMT2A |
| MAP kinase activity | MAPK1;NLK1;MAPK13;MAPK3;MAPK14A;MAPK8B;MAPK6;MAPK14B;NLK2 |
| phosphatase binding | SLC9A3R1;TPRN;ELL;ELFN2;TRPC4AP;WNK1;CSRNP2;SH3RF2;MAST2 |
| phosphotyrosine binding | LDLRAP1;SAMSN1;SHC1;PTPN3;ACP2;STAP1;MAPK3;GRB2;CBL |
| protein binding | PRMT8;HUWE1;NDFIP1;MEGF6;DTX3L;LCMT1;GLUD1;OSBPL6;NDUFS3 |
| scaffold protein binding | CACNA1H;KRT15;SHANK3;NLGN4Y;PDE4D;CASP8;CHUK;IKBKB;PANX1 |
MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr
Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
- Q&As
- Reviews
Ask a Question for All MAPK3 Products
Required fields are marked with *
My Review for All MAPK3 Products
Required fields are marked with *