MC4R
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Official Full Name
melanocortin 4 receptor
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Overview
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. -
Synonyms
MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R; MGC126851; MGC138197;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- Vulpes vulpes (Red fox)
- Zebrafish
- E.coli expression system
- HEK293
- HEK293T
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- C
- hFc
- His
- Fc
- Avi
- Flag
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MC4R involved in several pathways and played different roles in them. We selected most pathways MC4R participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Neuroactive ligand-receptor interaction | P2RX6;DRD1A;MLNR;P2RY4;GNRHR4;NPY8AR;GABRA4;TAAR10B;ADRA1BB |
MC4R has several biochemical functions, for example, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MC4R itself. We selected most functions MC4R had, and list some proteins which have the same functions with MC4R. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
melanocortin receptor activity | MC2R;MC4R;MC5RB;MC3R;MC1R;MC5RA;MC5R |
melanocyte-stimulating hormone receptor activity | MC1R;MC4R;MC3R |
neuropeptide binding | NPBWR1;SSTR2;OPRD1;SSTR5;GALR1;OPRD1B;GPR1;SSTR1;OPRL1 |
peptide hormone binding | NPR1;PTH1RA;HCRTR1;AGTR1B;GHRHR;AVPR1A;GALR2;PRLR;RXFP2 |
protein binding | FOXJ2;TWSG1;SIGLEC6;Fzd4;RAB10;SNX18;DPH3;MYO15;ZNF502 |
ubiquitin protein ligase binding | FZD8;MOAP1;EGFR;XBP1;PER1;DBT;PARK2;UBE2J1;CDC34B |
MC4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC4R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC4R.
MRAP; MRAP2; IL1RAP
Gene Family
Research Area
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