MC4R

  • Official Full Name

    melanocortin 4 receptor

  • Overview

    The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
  • Synonyms

    MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R; MGC126851; MGC138197;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Vulpes vulpes (Red fox)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Flag
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MC4R-305H Active Recombinant Human MC4R Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human MC4R-29453TH Recombinant Human MC4R Wheat Germ N/A 43 amino acids
Human MC4R-522H Recombinant Human MC4R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MC4R-695H Recombinant Human MC4R Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MC4R-1129HFL Recombinant Human MC4R protein, His&Flag-tagged HEK293 His&Flag 1-332 aa
Mouse MC4R-9617M Recombinant Mouse MC4R Protein Mammalian Cell His
Mouse MC4R-5402M-B Recombinant Mouse MC4R Protein Pre-coupled Magnetic Beads HEK293
Mouse Mc4r-292M Recombinant Mouse Mc4r Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-332aa
Mouse MC4R-5402M Recombinant Mouse MC4R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mc4r-3987M Recombinant Mouse Mc4r Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MC4R-3610R Recombinant Rat MC4R Protein Mammalian Cell His
Rat MC4R-3266R-B Recombinant Rat MC4R Protein Pre-coupled Magnetic Beads HEK293
Rat MC4R-3266R Recombinant Rat MC4R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL32343BF Recombinant Full Length Bovine Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Homo sapiens (Human) RFL4135HF Recombinant Full Length Human Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL10122MF Recombinant Full Length Macaca Fascicularis Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Mus musculus (Mouse) RFL35459MF Recombinant Full Length Mouse Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332aa)
Rattus norvegicus (Rat) RFL9956RF Recombinant Full Length Rat Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Sus scrofa (Pig) RFL8241SF Recombinant Full Length Pig Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Vulpes vulpes (Red fox) RFL2456VF Recombinant Full Length Vulpes Vulpes Melanocortin Receptor 4(Mc4R) Protein, His-Tagged E.coli expression system His Full Length (1-332)
Zebrafish MC4R-9549Z Recombinant Zebrafish MC4R Mammalian Cell His
Chicken MC4R-3159C Recombinant Chicken MC4R Mammalian Cell His
Kit-0883 Cell-Free Protein Expression Kit N/A
Kit-1375 cAMP MC4R CHO-K1 GPCR Assay Kit N/A
Kit-1036 DNAse I Activity Assay Kit (Fluorometric) N/A
Kit-1376 MC4R U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MC4R involved in several pathways and played different roles in them. We selected most pathways MC4R participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGRM2;GRIA1;CHRNA4;CHRNA7;LPAR6A;VIPR2;GABRA1;SSTR5;FPR2

MC4R has several biochemical functions, for example, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MC4R itself. We selected most functions MC4R had, and list some proteins which have the same functions with MC4R. You can find most of the proteins on our site.

Function Related Protein
melanocortin receptor activityMC5RA;MC4R;MC3R;MC2R;MC5RB;MC5R;MC1R
melanocyte-stimulating hormone receptor activityMC3R;MC1R;MC4R
neuropeptide bindingSSTR4;SSTR1;OPRD1B;NPY8BR;MC4R;GPR1;MRGPRB1;NPBWR1;GPR149
peptide hormone bindingNPR1;MAS1;PTH1R;PTH1RB;AGTR1A;EDNRB;GCGR;GALR2;GHRHR
protein bindingSDHAF2;CUL1;AGBL4;S100B;CEBPA;KAT7;VPS37A;TP53INP1;PVRL3
ubiquitin protein ligase bindingDIO2;MAGEA2;FHIT;BID;HSPA1L;TUBB;RFFL;CUL3B;CALR

MC4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC4R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC4R.

MRAP; MRAP2; IL1RAP

Gene Family

GPCRs

Research Area

Related articles

Shelkar, GP; Kale, AD; et al. Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors. ADDICTION BIOLOGY 20:302-315(2015).
Benjamins, JA; Nedelkoska, L; et al. Adrenocorticotropin Hormone 1-39 Promotes Proliferation and Differentiation of Oligodendroglial Progenitor Cells and Protects From Excitotoxic and Inflammation-Related Damage. JOURNAL OF NEUROSCIENCE RESEARCH 92:1243-1251(2014).
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