PPM1G

  • Official Full Name

    protein phosphatase, Mg2+/Mn2+ dependent, 1G

  • Overview

    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
  • Synonyms

    PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform; "PP2C; MGC1675; MGC2870; OTTHUMP00000123426; PP2C gamma; PP2C-gamma; PPM1G_HUMAN; PPP2CG; Protein phosphatase 1C; Protein phosphatase 2 catalytic subunit gamma isoform; Protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium dependent 1 gamma; Protein phosphatase magnesium-dependent 1 gamma; PP2C, gamma; protein phosphatase 2, catalytic subunit, gam;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPM1G-1756H Recombinant Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G, His-tagged Human His
Human PPM1G-1151H Recombinant Human PPM1G protein(Met317-Asp546), His-tagged E.coli N-His Met317-Asp546
Human PPM1G-3564H Recombinant Human PPM1G, His-tagged Human His
Human PPM1G-31050TH Recombinant Human PPM1G, His-tagged E.coli His
Human PPM1G-46H Recombinant Human PPM1G, His-tagged E.coli His
Human PPM1G-1896H Recombinant Human PPM1G, His-tagged E.coli His 191-546aa
Human PPM1G-2959HCL Recombinant Human PPM1G 293 Cell Lysate HEK293 N/A
Human PPM1G-2960HCL Recombinant Human PPM1G 293 Cell Lysate HEK293 N/A
Human PPM1G-1352H Recombinant Human PPM1G Protein, Flag-tagged HEK293T Flag
Human PPM1G-1745H-B Recombinant Human PPM1G Protein Pre-coupled Magnetic Beads HEK293
Human PPM1G-1353H Recombinant Human PPM1G Protein, Flag-tagged HEK293T Flag
Human PPM1G-001H Recombinant Human PPM1G Protein, GST-tagged Insect cell GST
Human PPM1G-5767H Recombinant Human PPM1G Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPM1G-5956H Recombinant Human PPM1G Protein (Met317-Asp546), C-His tagged E.coli C-His Met317-Asp546
Human PPM1G-560HFL Active Recombinant Full Length Human PPM1G Protein, C-Flag-tagged Mammalian cells Flag
Human PPM1G-1745H Recombinant Human PPM1G Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPM1G-13200M Recombinant Mouse PPM1G Protein Mammalian Cell His
Mouse PPM1G-6992M-B Recombinant Mouse PPM1G Protein Pre-coupled Magnetic Beads HEK293
Mouse Ppm1g-5048M Recombinant Mouse Ppm1g Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PPM1G-6992M Recombinant Mouse PPM1G Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PPM1G-805C Recombinant Cynomolgus PPM1G Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PPM1G-548C-B Recombinant Cynomolgus Monkey PPM1G Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PPM1G-548C Recombinant Cynomolgus Monkey PPM1G Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPM1G-3554R Recombinant Rhesus monkey PPM1G Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPM1G-3372R Recombinant Rhesus Macaque PPM1G Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPM1G-3372R-B Recombinant Rhesus Macaque PPM1G Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPM1G-11534Z Recombinant Zebrafish PPM1G Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PPM1G involved in several pathways and played different roles in them. We selected most pathways PPM1G participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA processingCLK2;DHX8;PTBP2;ZFP830;HNRNPH1L;MCTS2;BICC1;PRPF8;RBM39

PPM1G has several biochemical functions, for example, metal ion binding, protein binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1G itself. We selected most functions PPM1G had, and list some proteins which have the same functions with PPM1G. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingTDRD1;RAB11FIP3;GALNT13;LIAS;ARG2;GLRX2;GYG1;VAV3B;ZIC3
protein bindingGNG12;RANBP2;RAB18;KRTAP12-1;GAS1;EPB41L1;SIX3;MASP2;ATP2A2
protein serine/threonine phosphatase activityEPM2A;CTDNEP1A;CDC14AA;PPM1DB;PPM1LB;PPP1R3D;PPP1R15B;UBLCP1;PPM1AB

PPM1G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1G here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1G.

tat; TERF1; USP49; BAP1; USP7; USP36; TRAF6; LRPAP1; RPS6KA1; TERF2; acpA; FBXO38; TERF2IP; YEATS4; TP53; TFEB; MTNR1B

Research Area

Related articles

Husedzinovic, A; Neumann, B; et al. The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization. MOLECULAR BIOLOGY OF THE CELL 26:161-171(2015).
Chaudhary, N; Maddika, S; et al. WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and Delta Np73 Levels. MOLECULAR AND CELLULAR BIOLOGY 34:3754-3764(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can PPM1G be targeted for cancer treatment? 08/15/2022

Research is ongoing to explore the therapeutic potential of targeting PPM1G in cancer. Inhibiting or modulating its activity may be a strategy for cancer therapy.

Are there any known associations between PPM1G and cancer? 04/09/2022

Yes, abnormal expression of PPM1G has been linked to certain cancers, suggesting its potential role as a biomarker or therapeutic target.

Are there any genetic disorders associated with PPM1G mutations? 08/25/2020

While rare, mutations in the PPM1G gene have been reported and may be associated with certain genetic disorders. Further research is needed to understand the implications.

How does PPM1G contribute to DNA repair mechanisms? 12/30/2018

PPM1G is involved in the regulation of DNA repair processes, influencing the repair of damaged DNA and maintaining genomic stability.

Can PPM1G be used as a diagnostic marker for specific diseases? 03/13/2016

PPM1G expression levels may serve as a diagnostic marker for certain diseases, including some cancers, but more studies are required to establish its diagnostic utility.

Customer Reviews (3)

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Reviews
11/14/2022

    PPM1G protein's utility in protein electron microscopy structure analysis is commendable.

    12/03/2019

      It enables researchers to delve deeper into the intricacies of protein behavior and aids in advancing our knowledge in various fields, such as molecular biology, biochemistry, and structural biology.

      11/11/2019

        It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.

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