PPM1G
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Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1G
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Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. -
Synonyms
PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform; "PP2C; MGC1675; MGC2870; OTTHUMP00000123426; PP2C gamma; PP2C-gamma; PPM1G_HUMAN; PPP2CG; Protein phosphatase 1C; Protein phosphatase 2 catalytic subunit gamma isoform; Protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium dependent 1 gamma; Protein phosphatase magnesium-dependent 1 gamma; PP2C, gamma; protein phosphatase 2, catalytic subunit, gam;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Insect cell
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PPM1G involved in several pathways and played different roles in them. We selected most pathways PPM1G participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | DHX8;ADARB2;RNASET2B;ZFML;ZFP830;HNRNPH1L;SF3A1;EIF4E3;HNRNPL |
PPM1G has several biochemical functions, for example, metal ion binding, protein binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1G itself. We selected most functions PPM1G had, and list some proteins which have the same functions with PPM1G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | EGR2A;GEN1;ATP1A1A.5;SP6;COL5A2;SRSF7A;MTL5;CEPT1;Adcy4 |
| protein binding | ANK2;TSPAN15;SRSF5;PRPF8;PPM1K;RAB9A;PIAS4;OSBP2;SEPHS1 |
| protein serine/threonine phosphatase activity | MTMR3;PPM1AA;PDP1;LCK;PPM1B;PPM1A;PPM1F;PPP1R15B;PPM1K |
PPM1G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1G here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1G.
tat; TERF1; USP49; BAP1; USP7; USP36; TRAF6; LRPAP1; RPS6KA1; TERF2; acpA; FBXO38; TERF2IP; YEATS4; TP53; TFEB; MTNR1B
Research Area
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Customer Reviews (3)
Write a reviewPPM1G protein's utility in protein electron microscopy structure analysis is commendable.
It enables researchers to delve deeper into the intricacies of protein behavior and aids in advancing our knowledge in various fields, such as molecular biology, biochemistry, and structural biology.
It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.
Q&As (5)
Ask a questionResearch is ongoing to explore the therapeutic potential of targeting PPM1G in cancer. Inhibiting or modulating its activity may be a strategy for cancer therapy.
Yes, abnormal expression of PPM1G has been linked to certain cancers, suggesting its potential role as a biomarker or therapeutic target.
While rare, mutations in the PPM1G gene have been reported and may be associated with certain genetic disorders. Further research is needed to understand the implications.
PPM1G is involved in the regulation of DNA repair processes, influencing the repair of damaged DNA and maintaining genomic stability.
PPM1G expression levels may serve as a diagnostic marker for certain diseases, including some cancers, but more studies are required to establish its diagnostic utility.
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