Recombinant Human PPM1G Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PPM1G-5767H
• Product Overview: PPM1G MS Standard C13 and N15-labeled recombinant protein (NP_002698) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 59.3 kDa
• AA Sequence: MGAYLSQPNTVKCSGDGVGAPRLPL PYGFSAMQGWRVSMEDAHNCIPELD SETAMFSVYDGHGGEEVALYCAKYL PDIIKDQKAYKEGKLQKALEDAFLA IDAKLTTEEVIKELAQIAGRPTEDE DEKEKVADEDDVDNEEAALLHEEAT MTIEELLTRYGQNCHKGPPHSKSGG GTGEEPGSQGLNGEAGPEDSTRETP SQENGPTAKAYTGFSSNSERGTEAG QVGEPGIPTGEAGPSCSSASDKLPR VAKSKFFEDSEDESDEAEEEEEDSE ECSEEEDGYSSEEAENEEDEDDTEE AEEDDEEEEEEMMVPGMEGKEEPGS DSGTTAVVALIRGKQLIVANAGDSR CVVSEAGKALDMSYDHKPEDEVELA RIKNAGGKVTMDGRVNGGLNLSRAI GDHFYKRNKNLPPEEQMISALPDIK VLTLTDDHEFMVIACDGIWNVMSSQ EVVDFIQSKISQRDENGELRLLSSI VEELLDQCLAPDTSGDGTGCDNMTC IIICFKPRNTAELQPESGKRKLEEV LSTEGAEENGNSDKKKKAKRDTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G [ Homo sapiens (human) ]
• Official Symbol: PPM1G
• Synonyms: PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform; PP2C-gamma; PP2C, gamma; protein phosphatase 1C; protein phosphatase 2C gamma isoform; protein phosphatase 2C isoform gamma; protein phosphatase magnesium-dependent 1 gamma; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; PPP2CG; PP2CGAMMA; MGC1675; MGC2870
• Gene ID: 5496
• mRNA Refseq: NM_002707
• Protein Refseq: NP_002698
• MIM: 605119
• UniProt ID: O15355